{"id":"https://openalex.org/W2071050155","doi":"https://doi.org/10.1109/nebc.2010.5458260","title":"Permeability of in vitro blood-brain barrier models","display_name":"Permeability of in vitro blood-brain barrier models","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2071050155","doi":"https://doi.org/10.1109/nebc.2010.5458260","mag":"2071050155"},"language":"en","primary_location":{"id":"doi:10.1109/nebc.2010.5458260","doi":"https://doi.org/10.1109/nebc.2010.5458260","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2010.5458260","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101855868","display_name":"Guanglei Li","orcid":"https://orcid.org/0000-0002-5038-5039","observed_orcids":["https://orcid.org/0000-0002-5038-5039"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanglei Li","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082657329","display_name":"Melissa J. Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa J. Simon","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA","Department of Biomedical Engineering, Columbia University, New York, NY10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073402861","display_name":"Limary Melissa Cancel","orcid":"https://orcid.org/0000-0002-9872-1679","observed_orcids":["https://orcid.org/0000-0002-9872-1679"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limary Cancel","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033567624","display_name":"Zhong\u2010Dong Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong-Dong Shi","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111107535","display_name":"Xinyi Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyi Ji","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012970632","display_name":"John M. Tarbell","orcid":"https://orcid.org/0000-0001-6696-0272","observed_orcids":["https://orcid.org/0000-0001-6696-0272"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Tarbell","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019039663","display_name":"Barclay Morrison","orcid":"https://orcid.org/0000-0001-7676-0864","observed_orcids":["https://orcid.org/0000-0001-7676-0864"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barclay Morrison","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, New York, NY, USA","Department of Biomedical Engineering, Columbia University, New York, NY10027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, New York, NY10027","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000680941","display_name":"Bingmei M. Fu","orcid":"https://orcid.org/0000-0001-9343-5895","observed_orcids":["https://orcid.org/0000-0001-9343-5895"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingmei M. Fu","raw_affiliation_strings":["Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering,City College, City University of New York, New York, NY, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of the City University of New York, New York, NY10031","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11917098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9850000143051147},{"id":"https://openalex.org/keywords/in-vitro-bbb-model","display_name":"in vitro BBB model","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endothelial-monolayer","display_name":"endothelial monolayer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bend-3-cells","display_name":"bEnd.3 cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hydraulic-conductivity","display_name":"hydraulic conductivity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/diffusive-permeability","display_name":"diffusive permeability","score":0.9340000152587891},{"id":"https://openalex.org/keywords/solute-transport","display_name":"solute transport","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tamra","display_name":"TAMRA","score":0.949999988079071},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7348493337631226},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6137344837188721},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6085513234138489},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.5937321186065674},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.592008650302887},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5662670731544495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5515402555465698},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.546687126159668},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.517704963684082},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43052002787590027},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3406227231025696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2495191991329193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24634525179862976},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1376054584980011},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13296031951904297},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07925015687942505},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06196698546409607},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nebc.2010.5458260","doi":"https://doi.org/10.1109/nebc.2010.5458260","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2010.5458260","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309102","display_name":"City University of New York","ror":"https://ror.org/00453a208"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2040732222","https://openalex.org/W2051306620","https://openalex.org/W2070573684","https://openalex.org/W2074073922","https://openalex.org/W2097749873"],"related_works":["https://openalex.org/W2083230753","https://openalex.org/W2298133773","https://openalex.org/W230768509","https://openalex.org/W2385675905","https://openalex.org/W2092530725","https://openalex.org/W1855437336","https://openalex.org/W1988474837","https://openalex.org/W1896856524","https://openalex.org/W2977350049","https://openalex.org/W2051306620"],"abstract_inverted_index":{"The":[0,147],"blood-brain":[1],"barrier":[2],"(BBB)":[3],"is":[4],"a":[5],"major":[6],"obstacle":[7],"for":[8,14,21,133,142,162],"drug":[9],"delivery":[10],"to":[11,78],"the":[12,27,30,64,94,119,155,170],"brain":[13],"treatment":[15],"of":[16,44,75,93,118,165],"CNS":[17],"disorders.":[18],"To":[19],"search":[20],"more":[22],"convenient":[23],"models":[24,77,99,124,157,161],"in":[25,35,108,130],"studying":[26,163],"transport":[28,164],"across":[29,169],"BBB,":[31],"we":[32],"compared":[33],"four":[34],"vitro":[36],"models:":[37],"endothelial":[38,95,120,151],"monoculture":[39],"(bEnd3":[40],"cell":[41],"line),":[42],"coculture":[43,49,58,98,123,156],"bEnd3":[45],"and":[46,54,57,71,84,91,97,122,144,153],"astrocytes":[47],"(coculture),":[48],"with":[50,59,107],"collagen":[51],"type":[52],"I":[53],"IV":[55],"mixture,":[56],"Matrigel.":[60],"We":[61],"also":[62],"quantified":[63],"hydraulic":[65],"conductivity":[66],"(Lp),":[67],"trans-electrical":[68],"resistance":[69],"(TER)":[70],"diffusive":[72],"permeability":[73,110],"(P)":[74],"these":[76],"three":[79],"solutes:":[80],"TAMRA,":[81],"Dextran":[82,134,145],"10K":[83],"Dextran70K.":[85],"Our":[86],"results":[87,148],"showed":[88],"that":[89,150],"Lp":[90],"P":[92,117],"monolayer":[96,121,152],"are":[100,125,138,158],"not":[101,126],"different":[102,128],"from":[103,112,129],"each":[104],"other.":[105],"Compared":[106],"vivo":[109,131],"data":[111,132],"rat":[113],"pial":[114],"microvessels":[115],"[1],":[116],"significantly":[127],"70K":[135],"while":[136],"they":[137],"2-4":[139],"times":[140],"higher":[141],"TAMRA":[143],"10K.":[146],"suggested":[149],"all":[154],"fairly":[159],"good":[160],"relatively":[166],"large":[167],"solutes":[168],"BBB.":[171]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}