{"id":"https://openalex.org/W2070986325","doi":"https://doi.org/10.1016/0883-2897(86)90017-6","title":"Radioimmunodetection of human tumor xenografts by monoclonal antibody F(ab\u2032)2 fragments","display_name":"Radioimmunodetection of human tumor xenografts by monoclonal antibody F(ab\u2032)2 fragments","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2070986325","doi":"https://doi.org/10.1016/0883-2897(86)90017-6","mag":"2070986325","pmid":"https://pubmed.ncbi.nlm.nih.gov/3793494"},"language":"en","primary_location":{"id":"doi:10.1016/0883-2897(86)90017-6","doi":"https://doi.org/10.1016/0883-2897(86)90017-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0883-2897(86)90017-6","pdf_url":null,"source":{"id":"https://openalex.org/S59043349","display_name":"International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology","issn_l":"0883-2897","issn":["0883-2897","1878-2140"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021976445","display_name":"Dorothee Herlyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorothee Herlyn","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108087504","display_name":"John Powe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108691","display_name":"Victoria Hospital","ror":"https://ror.org/014tg6596","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800925808","https://openalex.org/I4210108691"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Powe","raw_affiliation_strings":["Victoria Hospital, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victoria Hospital, London, Ontario, Canada","institution_ids":["https://openalex.org/I4210108691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110403299","display_name":"Dieter Ludwig Munz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dieter L. Munz","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088003622","display_name":"Abass A. Alavi","orcid":"https://orcid.org/0000-0002-2442-7901","observed_orcids":["https://orcid.org/0000-0002-2442-7901"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abass Alavi","raw_affiliation_strings":["Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052523276","display_name":"George E. Meinken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George E. Meinken","raw_affiliation_strings":["Brookhaven National Laboratory, Upton, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookhaven National Laboratory, Upton, New York, U.S.A","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suresh C. Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh C. Srivastava","raw_affiliation_strings":["Brookhaven National Laboratory, Upton, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookhaven National Laboratory, Upton, New York, U.S.A","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050328478","display_name":"Hilary Koprowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilary Koprowski","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, U.S.A","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021976445"],"corresponding_institution_ids":["https://openalex.org/I102322052"],"apc_list":null,"apc_paid":null,"fwci":2.2612,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.87487344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"13","issue":"4","first_page":"401","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioimmunodetection","display_name":"radioimmunodetection","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.9789999723434448},{"id":"https://openalex.org/keywords/monoclonal-antibody-fragments","display_name":"monoclonal antibody fragments","score":0.7839999794960022},{"id":"https://openalex.org/keywords/f-ab-2-fragments","display_name":"F(ab')2 fragments","score":0.9710000157356262},{"id":"https://openalex.org/keywords/iodine-131-labeling","display_name":"iodine-131 labeling","score":0.8180000185966492},{"id":"https://openalex.org/keywords/indium-111-labeling","display_name":"indium-111 labeling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.7450000047683716},{"id":"https://openalex.org/keywords/immunosuppressed-mice","display_name":"immunosuppressed mice","score":0.7900000214576721},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tumor-to-background-ratio","display_name":"tumor-to-background ratio","score":0.7039999961853027},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/scatchard-analysis","display_name":"Scatchard analysis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.8607516288757324},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5764718651771545},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5638876557350159},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5606821179389954},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5356407165527344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4812438488006592},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47783422470092773},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4689098596572876},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4659937620162964},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.44895708560943604},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4479510188102722},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4408561885356903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34187039732933044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1901978850364685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1885475218296051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09747886657714844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07026448845863342},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007204","descriptor_name":"Indium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0883-2897(86)90017-6","doi":"https://doi.org/10.1016/0883-2897(86)90017-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0883-2897(86)90017-6","pdf_url":null,"source":{"id":"https://openalex.org/S59043349","display_name":"International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology","issn_l":"0883-2897","issn":["0883-2897","1878-2140"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","raw_type":"journal-article"},{"id":"pmid:3793494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3793494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G110904246","display_name":null,"funder_award_id":"CA 28462","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3471318205","display_name":null,"funder_award_id":"CA-10815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4919743768","display_name":null,"funder_award_id":"CA-18675","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W626981509","https://openalex.org/W1533446346","https://openalex.org/W1774805713","https://openalex.org/W1829525394","https://openalex.org/W1974044612","https://openalex.org/W1975199388","https://openalex.org/W1982862649","https://openalex.org/W1983649348","https://openalex.org/W2003072246","https://openalex.org/W2009601581","https://openalex.org/W2075592513","https://openalex.org/W2078837657","https://openalex.org/W2080580789","https://openalex.org/W2082935876","https://openalex.org/W2097496346","https://openalex.org/W2107017278","https://openalex.org/W2107155808","https://openalex.org/W2109338036","https://openalex.org/W2114139604","https://openalex.org/W2134844730","https://openalex.org/W2150891458","https://openalex.org/W2161137930","https://openalex.org/W2171019334","https://openalex.org/W2182637088","https://openalex.org/W2419284282","https://openalex.org/W2987283907"],"related_works":["https://openalex.org/W2150891458","https://openalex.org/W168566607","https://openalex.org/W2418917105","https://openalex.org/W1978394852","https://openalex.org/W2171019334","https://openalex.org/W1993002884","https://openalex.org/W1819842632","https://openalex.org/W2097496346","https://openalex.org/W2107017278","https://openalex.org/W2240695134"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}