{"id":"https://openalex.org/W2070959688","doi":"https://doi.org/10.1089/neu.2008.0582","title":"Current and Future Role of Therapeutic Hypothermia","display_name":"Current and Future Role of Therapeutic Hypothermia","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2070959688","doi":"https://doi.org/10.1089/neu.2008.0582","mag":"2070959688","pmid":"https://pubmed.ncbi.nlm.nih.gov/19292697"},"language":"en","primary_location":{"id":"doi:10.1089/neu.2008.0582","doi":"https://doi.org/10.1089/neu.2008.0582","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2008.0582","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061530547","display_name":"Donald W. Marion","orcid":"https://orcid.org/0000-0003-4627-7702","observed_orcids":["https://orcid.org/0000-0003-4627-7702"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donald Marion","raw_affiliation_strings":["The Children's Neurobiological Solutions Foundation, Santa Barbara, California","The Children's Neurobiological Solutions Foundation, Santa Barbara, California, USA. donmarion1@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Neurobiological Solutions Foundation, Santa Barbara, California","institution_ids":[]},{"raw_affiliation_string":"The Children's Neurobiological Solutions Foundation, Santa Barbara, California, USA. donmarion1@yahoo.com","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063816770","display_name":"M. Ross Bullock","orcid":"https://orcid.org/0000-0001-9842-5514","observed_orcids":["https://orcid.org/0000-0001-9842-5514"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ross Bullock","raw_affiliation_strings":["Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida","Neurological Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Neurological Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061530547"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6992,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.94086022,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"26","issue":"3","first_page":"455","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/moderate-hypothermia","display_name":"moderate hypothermia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9290000200271606},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.8059999942779541},{"id":"https://openalex.org/keywords/neonatal-hypoxic-ischemic-encephalopathy","display_name":"neonatal hypoxic-ischemic encephalopathy","score":0.953000009059906},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":1.0},{"id":"https://openalex.org/keywords/aneurysm-surgery","display_name":"aneurysm surgery","score":0.8949999809265137},{"id":"https://openalex.org/keywords/target-temperature","display_name":"target temperature","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.9217613339424133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.88298100233078},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.6099491715431213},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5999594926834106},{"id":"https://openalex.org/C2909832856","wikidata":"https://www.wikidata.org/wiki/Q2249526","display_name":"Hypoxic Ischemic Encephalopathy","level":3,"score":0.5497590899467468},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5291740298271179},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.4428110718727112},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36055195331573486},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.28182798624038696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20364445447921753},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017694","descriptor_name":"Rewarming","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017694","descriptor_name":"Rewarming","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017694","descriptor_name":"Rewarming","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D055416","descriptor_name":"Evidence-Based Emergency Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/neu.2008.0582","doi":"https://doi.org/10.1089/neu.2008.0582","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2008.0582","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:19292697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19292697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W15003916","https://openalex.org/W16798196","https://openalex.org/W46049638","https://openalex.org/W51215835","https://openalex.org/W167964840","https://openalex.org/W170253173","https://openalex.org/W205403498","https://openalex.org/W1506011769","https://openalex.org/W1599209235","https://openalex.org/W1643639871","https://openalex.org/W1908894092","https://openalex.org/W1966177964","https://openalex.org/W1971735819","https://openalex.org/W1972367009","https://openalex.org/W1973450490","https://openalex.org/W1974468880","https://openalex.org/W1974647231","https://openalex.org/W1975131252","https://openalex.org/W1976281868","https://openalex.org/W1977111115","https://openalex.org/W1977157041","https://openalex.org/W1977726159","https://openalex.org/W1980047462","https://openalex.org/W1980687193","https://openalex.org/W1981187981","https://openalex.org/W1981408803","https://openalex.org/W1982184322","https://openalex.org/W1984626942","https://openalex.org/W1987042677","https://openalex.org/W1988222409","https://openalex.org/W1988756839","https://openalex.org/W1991420375","https://openalex.org/W1993852765","https://openalex.org/W1995826793","https://openalex.org/W1995994129","https://openalex.org/W1996836135","https://openalex.org/W1997336878","https://openalex.org/W1998062141","https://openalex.org/W1999952466","https://openalex.org/W2000982837","https://openalex.org/W2001515223","https://openalex.org/W2005541858","https://openalex.org/W2006135584","https://openalex.org/W2007940803","https://openalex.org/W2008490486","https://openalex.org/W2008667312","https://openalex.org/W2009582227","https://openalex.org/W2013303926","https://openalex.org/W2014278455","https://openalex.org/W2015667316","https://openalex.org/W2016781450","https://openalex.org/W2018485653","https://openalex.org/W2023133533","https://openalex.org/W2023252093","https://openalex.org/W2024715321","https://openalex.org/W2025273970","https://openalex.org/W2026784965","https://openalex.org/W2027404569","https://openalex.org/W2028667207","https://openalex.org/W2029725588","https://openalex.org/W2037785539","https://openalex.org/W2046934316","https://openalex.org/W2048378282","https://openalex.org/W2054544499","https://openalex.org/W2054947514","https://openalex.org/W2055235177","https://openalex.org/W2062642814","https://openalex.org/W2064507376","https://openalex.org/W2067737380","https://openalex.org/W2069668391","https://openalex.org/W2070145664","https://openalex.org/W2070680926","https://openalex.org/W2071501210","https://openalex.org/W2071880140","https://openalex.org/W2073903257","https://openalex.org/W2076858103","https://openalex.org/W2076919074","https://openalex.org/W2076944939","https://openalex.org/W2077017039","https://openalex.org/W2077647582","https://openalex.org/W2079309743","https://openalex.org/W2084913733","https://openalex.org/W2086242517","https://openalex.org/W2087277695","https://openalex.org/W2088277539","https://openalex.org/W2090108341","https://openalex.org/W2090335404","https://openalex.org/W2090338414","https://openalex.org/W2091859641","https://openalex.org/W2094287992","https://openalex.org/W2104869294","https://openalex.org/W2106682644","https://openalex.org/W2106824039","https://openalex.org/W2107763730","https://openalex.org/W2110045115","https://openalex.org/W2111514631","https://openalex.org/W2111703215","https://openalex.org/W2112164385","https://openalex.org/W2112179638","https://openalex.org/W2112517536","https://openalex.org/W2113909339","https://openalex.org/W2114888710","https://openalex.org/W2118846431","https://openalex.org/W2120383878","https://openalex.org/W2121451738","https://openalex.org/W2123730734","https://openalex.org/W2123930114","https://openalex.org/W2124411416","https://openalex.org/W2128826387","https://openalex.org/W2129282872","https://openalex.org/W2130143178","https://openalex.org/W2130692137","https://openalex.org/W2132315724","https://openalex.org/W2135122869","https://openalex.org/W2135796244","https://openalex.org/W2142823800","https://openalex.org/W2146937621","https://openalex.org/W2153229538","https://openalex.org/W2154896935","https://openalex.org/W2155034622","https://openalex.org/W2155532438","https://openalex.org/W2158193496","https://openalex.org/W2160119511","https://openalex.org/W2162472063","https://openalex.org/W2162686263","https://openalex.org/W2163173773","https://openalex.org/W2164127547","https://openalex.org/W2169002441","https://openalex.org/W2171218071","https://openalex.org/W2172066590","https://openalex.org/W2259397836","https://openalex.org/W2327295093","https://openalex.org/W2333052542","https://openalex.org/W2346987334","https://openalex.org/W2409806637","https://openalex.org/W2472614888","https://openalex.org/W4244037519","https://openalex.org/W4254888402"],"related_works":["https://openalex.org/W4229933716","https://openalex.org/W144022752","https://openalex.org/W2099556742","https://openalex.org/W1805335624","https://openalex.org/W7048988972","https://openalex.org/W2054376401","https://openalex.org/W2115250852","https://openalex.org/W2578217332","https://openalex.org/W2383945814","https://openalex.org/W2165586179"],"abstract_inverted_index":{"Therapeutic":[0],"moderate":[1],"hypothermia":[2,154],"has":[3],"been":[4,41],"advocated":[5],"for":[6,43,71,96],"use":[7,152],"in":[8],"traumatic":[9,105],"brain":[10,106],"injury,":[11,24,107,140],"stroke,":[12],"cardiac":[13,98],"arrest-induced":[14],"encephalopathy,":[15,18,20],"neonatal":[16,101],"hypoxic-ischemic":[17,102],"hepatic":[19],"and":[21,25,48,82,90,100,137],"spinal":[22,138],"cord":[23,139],"as":[26,74,76,135],"an":[27,67],"adjunct":[28],"to":[29,55,65,149],"aneurysm":[30],"surgery.":[31],"In":[32],"this":[33,156],"review,":[34],"we":[35],"address":[36],"the":[37,50,53,63,77,80,83,116,131,145],"trials":[38,141],"that":[39,112],"have":[40],"performed":[42],"each":[44,72],"of":[45,52,79,118,130,153],"these":[46],"indications,":[47,133],"review":[49,62],"strength":[51],"evidence":[54],"support":[56,66],"treatment":[57],"with":[58],"mild/moderate":[59],"hypothermia.":[60],"We":[61],"data":[64,146],"optimal":[68],"target":[69],"temperature":[70],"indication,":[73],"well":[75],"duration":[78],"cooling,":[81],"rate":[84],"at":[85,155],"which":[86],"cooling":[87,113],"is":[88,94],"induced":[89],"rewarming":[91],"instituted.":[92],"Evidence":[93],"strongest":[95],"prehospital":[97],"arrest":[99],"encephalopathy.":[103],"For":[104,128],"a":[108,119],"recent":[109],"meta-analysis":[110],"suggests":[111],"may":[114],"increase":[115],"likelihood":[117],"good":[120],"outcome,":[121],"but":[122,144],"does":[123],"not":[124],"change":[125],"mortality":[126],"rates.":[127],"many":[129],"other":[132],"such":[134],"stroke":[136],"are":[142,147],"ongoing,":[143],"insufficient":[148],"recommend":[150],"routine":[151],"time.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
