{"id":"https://openalex.org/W2070913775","doi":"https://doi.org/10.1097/00041552-200209000-00011","title":"New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia","display_name":"New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2070913775","doi":"https://doi.org/10.1097/00041552-200209000-00011","mag":"2070913775","pmid":"https://pubmed.ncbi.nlm.nih.gov/12187320"},"language":"en","primary_location":{"id":"doi:10.1097/00041552-200209000-00011","doi":"https://doi.org/10.1097/00041552-200209000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-200209000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605270","display_name":"Rajiv Kumar","orcid":"https://orcid.org/0000-0003-3497-3057","observed_orcids":["https://orcid.org/0000-0003-3497-3057"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajiv Kumar","raw_affiliation_strings":["Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. rkumar@mayo.edu","ADHR: autosomal-dominant hypophosphatemic rickets","Departments of Internal Medicine, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","FGF: fibroblast growth factor","PTH: parathyroid hormone","to Rajiv Kumar, Departments of Internal Medicine, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. rkumar@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"ADHR: autosomal-dominant hypophosphatemic rickets","institution_ids":[]},{"raw_affiliation_string":"Departments of Internal Medicine, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"FGF: fibroblast growth factor","institution_ids":[]},{"raw_affiliation_string":"PTH: parathyroid hormone","institution_ids":[]},{"raw_affiliation_string":"to Rajiv Kumar, Departments of Internal Medicine, Biochemistry and Molecular Biology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100605270"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":1.7802,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.84210526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"5","first_page":"547","last_page":"553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-induced-osteomalacia","display_name":"tumor-induced osteomalacia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/x-linked-hypophosphatemia","display_name":"X-linked hypophosphatemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/autosomal-dominant-hypophosphatemic-rickets","display_name":"autosomal dominant hypophosphatemic rickets","score":0.9879999756813049},{"id":"https://openalex.org/keywords/renal-phosphate-excretion","display_name":"renal phosphate excretion","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hypophosphatemia","display_name":"hypophosphatemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/phex","display_name":"PHEX","score":0.7110000252723694},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/rickets","display_name":"rickets","score":0.5590000152587891},{"id":"https://openalex.org/keywords/mineral-metabolism","display_name":"mineral metabolism","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2776338720","wikidata":"https://www.wikidata.org/wiki/Q14913440","display_name":"PHEX","level":4,"score":0.938491940498352},{"id":"https://openalex.org/C2778049618","wikidata":"https://www.wikidata.org/wiki/Q860395","display_name":"Osteomalacia","level":3,"score":0.916352391242981},{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.9146410822868347},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.8623834848403931},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.8232090473175049},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.7553119659423828},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7150156497955322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6664937734603882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33197638392448425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2882383465766907},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.27754855155944824},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.06360161304473877},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.052671998739242554}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010018","descriptor_name":"Osteomalacia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00041552-200209000-00011","doi":"https://doi.org/10.1097/00041552-200209000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041552-200209000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S185853653","display_name":"Current Opinion in Nephrology & Hypertension","issn_l":"1062-4821","issn":["1062-4821","1080-8221","1473-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Nephrology and Hypertension","raw_type":"journal-article"},{"id":"pmid:12187320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12187320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in nephrology and hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3604623962","display_name":null,"funder_award_id":"AR27032","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4653449631","display_name":null,"funder_award_id":"DK 58546","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7191392185","display_name":null,"funder_award_id":"DK 25409","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8472333369","display_name":"Role of Vitamin D in Dendritic Cell Immune Functions","funder_award_id":"R01DK059505","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8583273390","display_name":"THE PHYSIOLOGY AND METABOLISM OF VITAMIN D","funder_award_id":"R01DK025409","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8825461012","display_name":"THE STRUCTURE OF CALBINDIN-D28K","funder_award_id":"R01DK058546","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G945531938","display_name":null,"funder_award_id":"DK-59505","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W13034644","https://openalex.org/W1557286785","https://openalex.org/W1563425273","https://openalex.org/W1595161814","https://openalex.org/W1963640137","https://openalex.org/W1966313141","https://openalex.org/W1969680903","https://openalex.org/W1984515301","https://openalex.org/W1987381793","https://openalex.org/W1987998131","https://openalex.org/W2000004275","https://openalex.org/W2000736072","https://openalex.org/W2008101181","https://openalex.org/W2009153723","https://openalex.org/W2009307816","https://openalex.org/W2009466544","https://openalex.org/W2010499252","https://openalex.org/W2010798525","https://openalex.org/W2011368668","https://openalex.org/W2016181050","https://openalex.org/W2018485982","https://openalex.org/W2020138048","https://openalex.org/W2020380034","https://openalex.org/W2029781656","https://openalex.org/W2030355077","https://openalex.org/W2040552779","https://openalex.org/W2040685503","https://openalex.org/W2040704811","https://openalex.org/W2045129957","https://openalex.org/W2047559290","https://openalex.org/W2051182063","https://openalex.org/W2055383210","https://openalex.org/W2057567913","https://openalex.org/W2061609858","https://openalex.org/W2062049304","https://openalex.org/W2062741205","https://openalex.org/W2064377241","https://openalex.org/W2068226571","https://openalex.org/W2069799214","https://openalex.org/W2070517674","https://openalex.org/W2079384527","https://openalex.org/W2086635932","https://openalex.org/W2089464041","https://openalex.org/W2091469182","https://openalex.org/W2092959403","https://openalex.org/W2096914844","https://openalex.org/W2102257702","https://openalex.org/W2104556836","https://openalex.org/W2106503825","https://openalex.org/W2110631456","https://openalex.org/W2123911734","https://openalex.org/W2170351820","https://openalex.org/W2271595093","https://openalex.org/W2293638411","https://openalex.org/W2312306660","https://openalex.org/W2323794918","https://openalex.org/W2340356357","https://openalex.org/W2409789927","https://openalex.org/W2417113648","https://openalex.org/W4237671297","https://openalex.org/W4249310126","https://openalex.org/W4252724004"],"related_works":["https://openalex.org/W2095116545","https://openalex.org/W2005251763","https://openalex.org/W2097951001","https://openalex.org/W1889030353","https://openalex.org/W4281619880","https://openalex.org/W2141482249","https://openalex.org/W2045129957","https://openalex.org/W2124824039","https://openalex.org/W2025339350","https://openalex.org/W2111607881"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Studies":[3],"of":[4,30,32,76,181,194,226,237],"patients":[5,127],"with":[6,9,68,83,110,128,135,147,168,192,203,215],"tumors":[7],"associated":[8,82,167,191],"osteomalacia":[10,84],"(tumor-induced":[11],"osteomalacia),":[12],"X-linked":[13],"hypophosphatemia":[14],"(XLH)":[15],"and":[16,28,43,93,106,133,173,187,207,251],"autosomal-dominant":[17,148,231],"hypophosphatemic":[18,149,232],"rickets":[19,72,150],"have":[20],"provided":[21],"important":[22],"new":[23],"insights":[24],"into":[25],"the":[26,48,143,221],"identity":[27],"mechanisms":[29],"action":[31],"factors":[33,86,99,182],"that":[34,88,117,156,240],"play":[35],"a":[36,74,114,137,152,227,234],"role":[37],"in":[38,120,126],"controlling":[39],"renal":[40,90,170,248],"phosphate":[41,45,79,91,96,171,249],"excretion":[42,92,172],"serum":[44,95],"concentrations.":[46,97],"In":[47,131,176,209,230],"present":[49],"review":[50],"I":[51],"discuss":[52],"how":[53],"these":[54,69,200],"disorders":[55,70],"may":[56],"be":[57],"mechanistically":[58],"related":[59],"to":[60,124,159,198,217,243],"one":[61],"another.":[62],"RECENT":[63],"FINDINGS:":[64],"Patients":[65,146],"(or":[66],"mice)":[67],"manifest":[71],"as":[73,184],"result":[75],"excessive":[77,179],"urinary":[78],"losses.":[80],"Tumors":[81],"elaborate":[85,113],"('phosphatonins')":[87],"increase":[89],"reduce":[94],"These":[98],"include":[100],"fibroblast":[101],"growth":[102],"factor":[103,116],"(FGF)":[104],"23":[105,155,164,186,239],"frizzled-related":[107,188],"protein-4.":[108],"Mice":[109],"XLH":[111],"(Hyp)":[112],"circulating":[115],"induces":[118],"changes":[119],"mineral":[121],"metabolism":[122],"similar":[123],"those":[125],"tumor-induced":[129,177],"osteomalacia.":[130],"mice":[132],"humans":[134],"XLH,":[136,210],"mutant":[138,153,211,235],"enzyme,":[139],"phex/PHEX,":[140],"cannot":[141],"degrade":[142,199],"phosphaturic":[144,228],"factor.":[145,229],"produce":[151],"FGF":[154,163,185,238],"is":[157,166,190,241],"resistant":[158,242],"proteolytic":[160,196,244],"degradation.":[161],"Excessive":[162],"activity":[165,223],"increased":[169,247],"hypophosphatemia.":[174,252],"SUMMARY:":[175],"osteomalacia,":[178],"production":[180],"such":[183],"protein-4":[189],"inability":[193],"endogenous":[195],"enzymes":[197],"individual":[201],"substances,":[202],"resultant":[204],"hyperphosphaturia,":[205],"hypophosphatemia,":[206],"rickets.":[208],"PHEX/phex":[212],"(phosphate-regulating":[213],"gene":[214],"homology":[216],"endopeptidases":[218],"located":[219],"on":[220],"X-chromosome)":[222],"prevents":[224],"degradation":[225,245],"rickets,":[233],"form":[236],"causes":[246],"losses":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
