{"id":"https://openalex.org/W2070911191","doi":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","title":"Monitoring and management of antituberculosis drug induced hepatotoxicity","display_name":"Monitoring and management of antituberculosis drug induced hepatotoxicity","publication_year":2005,"publication_date":"2005-10-12","ids":{"openalex":"https://openalex.org/W2070911191","doi":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","mag":"2070911191","pmid":"https://pubmed.ncbi.nlm.nih.gov/16246196"},"language":"en","primary_location":{"id":"doi:10.1111/j.1440-1746.2005.04048.x","doi":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070819008","display_name":"Subhash Agal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SUBHASH AGAL","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital, Mumbai, India","Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital, Mumbai, India","institution_ids":[]},{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069714710","display_name":"Rajiv Baijal","orcid":"https://orcid.org/0000-0003-3870-5463","observed_orcids":["https://orcid.org/0000-0003-3870-5463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RAJIV BAIJAL","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011196422","display_name":"SNEHANSHU PRAMANIK","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SNEHANSHU PRAMANIK","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"NIKHIL PATEL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NIKHIL PATEL","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110171337","display_name":"Parijat Gupte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PARIJAT GUPTE","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039721863","display_name":"Praful M. Kamani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PRAFUL KAMANI","raw_affiliation_strings":["Department of Gastroenterology, Jagjivanram Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jagjivanram Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109117279","display_name":"Deepak Narayan Amarapurkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135821","display_name":"Bombay Hospital","ror":"https://ror.org/03xmsh521","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210135821"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"DEEPAK AMARAPURKAR","raw_affiliation_strings":["Department of Gastroenterology, Bombay Hospital, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Bombay Hospital, Mumbai, India","institution_ids":["https://openalex.org/I4210135821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":1.5257,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.79536082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"11","first_page":"1745","last_page":"1752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antituberculosis-drug-hepatotoxicity","display_name":"antituberculosis drug hepatotoxicity","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8209999799728394},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.6119999885559082},{"id":"https://openalex.org/keywords/icteric-hepatitis","display_name":"icteric hepatitis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9602357149124146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7108251452445984},{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.5837651491165161},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5673383474349976},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5281757712364197},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5057406425476074},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.45100581645965576},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.42049339413642883},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32927757501602173},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.18039441108703613},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1440-1746.2005.04048.x","doi":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1440-1746.2005.04048.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:16246196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16246196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306606","display_name":"American Thoracic Society","ror":"https://ror.org/0547sz392"},{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W11309145","https://openalex.org/W23443588","https://openalex.org/W1541618700","https://openalex.org/W1989219811","https://openalex.org/W1992242940","https://openalex.org/W1997770373","https://openalex.org/W1999481211","https://openalex.org/W2000188603","https://openalex.org/W2003168515","https://openalex.org/W2007946569","https://openalex.org/W2008562619","https://openalex.org/W2008592878","https://openalex.org/W2042651010","https://openalex.org/W2047966951","https://openalex.org/W2054788130","https://openalex.org/W2064727915","https://openalex.org/W2084662873","https://openalex.org/W2095134596","https://openalex.org/W2110149852","https://openalex.org/W2121017558","https://openalex.org/W2135798575","https://openalex.org/W2264481448","https://openalex.org/W2394686291","https://openalex.org/W2411676229","https://openalex.org/W2418210342","https://openalex.org/W3021092633","https://openalex.org/W4232980938","https://openalex.org/W4235509352","https://openalex.org/W4236577871","https://openalex.org/W4240228767","https://openalex.org/W4317648969"],"related_works":["https://openalex.org/W2008592878","https://openalex.org/W181309676","https://openalex.org/W7162026990","https://openalex.org/W2022843037","https://openalex.org/W2333742359","https://openalex.org/W4240906061","https://openalex.org/W4396238395","https://openalex.org/W2525658659","https://openalex.org/W1984955220","https://openalex.org/W4399266034"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hepatotoxicity":[1],"to":[2,72],"antituberculosis":[3],"therapy":[4],"(ATT)":[5],"poses":[6],"a":[7,66,170,222],"major":[8],"challenge.":[9],"This":[10],"often":[11,284],"results":[12],"in":[13,81,115,185,203,211,243,253,271],"inadequate":[14],"therapy.":[15],"The":[16],"risk":[17],"of":[18,41,49,59,68,93,124,160,180,225,261],"fulminant":[19],"hepatic":[20],"failure":[21],"and":[22,37,52,56,153,236],"mortality":[23,223],"is":[24,31,269,283],"high":[25],"once":[26],"icteric":[27,197,218],"hepatitis":[28,216],"develops.":[29],"There":[30,199,220],"no":[32,201],"consensus":[33],"on":[34],"monitoring":[35,89,268],"protocols":[36],"for":[38,85,90,163],"the":[39,47,57,76,82,91,122,130,140,181,186,209,230,247],"reintroduction":[40,165,240,256,282],"ATT.":[42],"METHODS:":[43],"All":[44],"patients":[45,96,131,182,190,210,232,250],"(from":[46],"Department":[48,58],"Internal":[50],"Medicine":[51],"Gastroenterology,":[53,60],"Jagjivanram":[54],"Hospital":[55],"Bombay":[61],"Hospital,":[62],"Mumbai,":[63],"India)":[64],"with":[65,126,135,166],"diagnosis":[67],"tuberculosis,":[69],"who":[70,97,108,132,238,251],"were":[71,79,113,143,155,183,200,252],"receive":[73],"ATT":[74,136],"during":[75,139],"study":[77,84,141],"period,":[78],"included":[80,114],"present":[83],"prospective":[86],"periodic":[87],"laboratory":[88,267],"development":[92],"hepatotoxicity.":[94],"Those":[95],"developed":[98],"hepatotoxicity":[99,112,138,273],"formed":[100],"Group":[101,116,127,146,151,175,204,212,254],"A":[102,152,235],"(n":[103,118,148],"=":[104,119,149],"21),":[105],"whereas":[106],"those":[107],"did":[109],"not":[110,258],"develop":[111],"C":[117],"179).":[120],"For":[121],"purpose":[123],"comparison":[125],"A,":[128,176],"all":[129,208],"presented":[133],"directly":[134],"induced":[137],"period":[142],"categorized":[144],"as":[145],"B":[147,154,213,237],"24).":[150],"further":[156],"studied":[157],"after":[158],"normalization":[159],"liver":[161,263],"functions":[162],"sequential":[164],"therapeutic":[167],"doses":[168],"at":[169,274],"weekly":[171],"interval.":[172],"RESULTS:":[173],"In":[174,206,246],"66.6%":[177],"(14":[178],"patients)":[179],"diagnosed":[184],"asymptomatic":[187],"period.":[188],"Seven":[189],"had":[191,196,214],"symptomatic":[192,215],"hepatitis,":[193],"but":[194],"none":[195],"illness.":[198],"mortalities":[202],"A.":[205],"contrast,":[207],"(75%":[217],"hepatitis).":[219],"was":[221,241,257],"rate":[224],"16.6%":[226],"(four":[227],"patients).":[228],"Of":[229],"41":[231],"from":[233],"Groups":[234],"survived,":[239],"successful":[242],"38/39":[244],"(97.4%).":[245],"remaining":[248],"two":[249],"B,":[255],"attempted":[259],"because":[260],"decompensated":[262],"disease.":[264],"CONCLUSIONS:":[265],"Periodic":[266],"important":[270],"detecting":[272],"an":[275],"early":[276],"stage,":[277],"thereby":[278],"preventing":[279],"mortality.":[280],"Sequential":[281],"successful.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}