{"id":"https://openalex.org/W2070847866","doi":"https://doi.org/10.1021/acschembio.5b00240","title":"Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells","display_name":"Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells","publication_year":2015,"publication_date":"2015-04-14","ids":{"openalex":"https://openalex.org/W2070847866","doi":"https://doi.org/10.1021/acschembio.5b00240","mag":"2070847866","pmid":"https://pubmed.ncbi.nlm.nih.gov/25871544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701379"},"language":"en","primary_location":{"id":"doi:10.1021/acschembio.5b00240","doi":"https://doi.org/10.1021/acschembio.5b00240","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.5b00240","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701379","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112215898","display_name":"Daniel I. Benjamin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel I. Benjamin","raw_affiliation_strings":["Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011924147","display_name":"Daniel S. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Li","raw_affiliation_strings":["Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004634283","display_name":"W. L. Lowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace Lowe","raw_affiliation_strings":["Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063172780","display_name":"Timothy S. Heuer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Heuer","raw_affiliation_strings":["3V Biosciences, Inc., 1050\rHamilton Ct., Menlo Park, California 94025, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3V Biosciences, Inc., 1050\rHamilton Ct., Menlo Park, California 94025, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010601658","display_name":"George\u00a0W. Kemble","orcid":"https://orcid.org/0000-0003-4225-8774","observed_orcids":["https://orcid.org/0000-0003-4225-8774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kemble","raw_affiliation_strings":["3V Biosciences, Inc., 1050\rHamilton Ct., Menlo Park, California 94025, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3V Biosciences, Inc., 1050\rHamilton Ct., Menlo Park, California 94025, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035184259","display_name":"Daniel K. Nomura","orcid":"https://orcid.org/0000-0003-1614-8360","observed_orcids":["https://orcid.org/0000-0003-1614-8360"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel K. Nomura","raw_affiliation_strings":["Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program\rin Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, California 94720, United States","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035184259","https://openalex.org/A5112215898"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9414,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92139245,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"1616","last_page":"1623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/fasn-inhibitors","display_name":"FASN inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/diacylglycerol-metabolism","display_name":"diacylglycerol metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/diacylglycerol-signaling","display_name":"diacylglycerol signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cancer-cell-sensitivity","display_name":"tumor cell sensitivity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.46399998664855957},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.6140000224113464},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.7658798694610596},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6310293674468994},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.6248563528060913},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5355671644210815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5331382751464844},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49645930528640747},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.45156410336494446},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4213104546070099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4121987819671631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38277190923690796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36967790126800537},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36316749453544617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06665924191474915}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064429","descriptor_name":"Fatty Acid Synthases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064429","descriptor_name":"Fatty Acid Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acschembio.5b00240","doi":"https://doi.org/10.1021/acschembio.5b00240","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschembio.5b00240","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmid:25871544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25871544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4701379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701379","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4701379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4701379","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1977860408","display_name":null,"funder_award_id":"RSG\u201014\u2010242\u201001\u2010TBE","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G5557841070","display_name":"Pre-doctoral Training in Molecular and Biochemical Nutrition","funder_award_id":"T32DK061918","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6309066425","display_name":"Annotating the Role of Dysregulated Inositol Phosphate Metabolism in Malignant Ca","funder_award_id":"R01CA172667","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7052300792","display_name":"CHARACTERIZING PAFAH1B3 AS A NOVEL METABOLIC TARGET FOR BREAST CANCER THERAPY","funder_award_id":"W81XWH1510050","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320308646","display_name":"Kinship Foundation","ror":"https://ror.org/05pt1d114"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1976062660","https://openalex.org/W1987496015","https://openalex.org/W1992203600","https://openalex.org/W2015012139","https://openalex.org/W2036536263","https://openalex.org/W2040942138","https://openalex.org/W2059609101","https://openalex.org/W2092152920","https://openalex.org/W2104542806","https://openalex.org/W2127624416","https://openalex.org/W2128738080","https://openalex.org/W2153178365","https://openalex.org/W2162592716"],"related_works":["https://openalex.org/W2894298716","https://openalex.org/W3139225685","https://openalex.org/W2945942656","https://openalex.org/W3015519369","https://openalex.org/W2890758692","https://openalex.org/W2563493392","https://openalex.org/W6887603804","https://openalex.org/W2395187593","https://openalex.org/W2587150357","https://openalex.org/W2066864798"],"abstract_inverted_index":{"Fatty":[0],"acid":[1],"synthase":[2],"(FASN)":[3],"generates":[4],"the":[5,42,77,144],"de":[6],"novo":[7],"source":[8],"of":[9,22,30,45,61,79,81,147],"lipids":[10],"for":[11,127],"cell":[12,110],"proliferation":[13],"and":[14,32,103,107,115],"is":[15],"a":[16,27,125,136,139],"promising":[17],"cancer":[18,34,50,132],"therapy":[19],"target.":[20],"Development":[21],"FASN":[23,46,70,94,129,148],"inhibitors,":[24],"however,":[25],"necessitates":[26],"better":[28],"understanding":[29],"sensitive":[31,98,113],"resistant":[33,101,117],"types":[35],"to":[36,100],"optimize":[37],"patient":[38],"treatment.":[39],"Indeed,":[40],"testing":[41],"cytotoxic":[43],"effects":[44,146],"inhibition":[47],"across":[48],"human":[49],"cells":[51,102,114,133],"revealed":[52],"diverse":[53],"sensitivities.":[54],"We":[55,73],"show":[56,75],"here":[57],"that":[58,76,104],"metabolic":[59],"incorporation":[60],"glucose":[62],"into":[63],"specific":[64],"complex":[65],"lipid":[66,83],"species":[67],"strongly":[68],"predicts":[69],"inhibitor":[71,95],"sensitivity.":[72],"also":[74,135],"levels":[78],"one":[80],"these":[82],"classes,":[84],"protein":[85],"kinase":[86],"C":[87],"(PKC)":[88],"stimulator":[89],"diacylglycerols,":[90],"are":[91],"lowered":[92],"upon":[93],"treatment":[96],"in":[97,112,131],"compared":[99],"PKC":[105],"activators":[106],"inhibitors":[108],"rescue":[109],"death":[111],"sensitize":[116],"cells,":[118],"respectively.":[119],"Our":[120],"findings":[121],"not":[122],"only":[123],"reveal":[124],"biomarker":[126],"predicting":[128],"sensitivity":[130],"but":[134],"put":[137],"forth":[138],"heretofore":[140],"unrecognized":[141],"mechanism":[142],"underlying":[143],"anticancer":[145],"inhibitors.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
