{"id":"https://openalex.org/W2070799178","doi":"https://doi.org/10.3390/ijms151121179","title":"The Stability of G6PD Is Affected by Mutations with Different Clinical Phenotypes","display_name":"The Stability of G6PD Is Affected by Mutations with Different Clinical Phenotypes","publication_year":2014,"publication_date":"2014-11-17","ids":{"openalex":"https://openalex.org/W2070799178","doi":"https://doi.org/10.3390/ijms151121179","mag":"2070799178","pmid":"https://pubmed.ncbi.nlm.nih.gov/25407525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4264219"},"language":"en","primary_location":{"id":"doi:10.3390/ijms151121179","doi":"https://doi.org/10.3390/ijms151121179","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151121179","pdf_url":"https://www.mdpi.com/1422-0067/15/11/21179/pdf?version=1416217314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/15/11/21179/pdf?version=1416217314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039624943","display_name":"Sa\u00fal G\u00f3mez\u2010Manzo","orcid":"https://orcid.org/0000-0003-2095-9182","observed_orcids":["https://orcid.org/0000-0003-2095-9182"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Sa\u00fal G\u00f3mez-Manzo","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. saulmanzo@ciencias.unam.mx"],"raw_orcid":"https://orcid.org/0000-0003-2095-9182","affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. saulmanzo@ciencias.unam.mx","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067233187","display_name":"Jessica Terr\u00f3n-Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jessica Terr\u00f3n-Hern\u00e1ndez","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. yssterron@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. yssterron@hotmail.com","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ignacio De la Mora-De la Mora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ignacio De la Mora-De la Mora","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. ignaciodelamora@yahoo.com.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. ignaciodelamora@yahoo.com.mx","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059076205","display_name":"Abigail Gonz\u00e1lez\u2010Valdez","orcid":"https://orcid.org/0000-0001-8063-051X","observed_orcids":["https://orcid.org/0000-0001-8063-051X"]},"institutions":[{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Abigail Gonz\u00e1lez-Valdez","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Biotecnolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico","Departamento de Biolog\u00eda Molecular y Biotecnolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico. abigaila@correo.biomedicas.unam.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Biotecnolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Biotecnolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico. abigaila@correo.biomedicas.unam.mx","institution_ids":["https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067117517","display_name":"Jaime Marcial\u2010Quino","orcid":"https://orcid.org/0000-0002-4591-7379","observed_orcids":["https://orcid.org/0000-0002-4591-7379"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]},{"id":"https://openalex.org/I4210163111","display_name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","ror":"https://ror.org/059ex5q34","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210163111"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jaime Marcial-Quino","raw_affiliation_strings":["CONACyT, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","CONACyT, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. jmarcialqu@conacyt.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CONACyT, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"CONACyT, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. jmarcialqu@conacyt.mx","institution_ids":["https://openalex.org/I4210146908","https://openalex.org/I4210163111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080329735","display_name":"Itzhel Garc\u00eda\u2010Torres","orcid":"https://orcid.org/0000-0002-3018-060X","observed_orcids":["https://orcid.org/0000-0002-3018-060X"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Itzhel Garc\u00eda-Torres","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. itzheltorres@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. itzheltorres@hotmail.com","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040351367","display_name":"Am\u00e9rica Vanoye\u2013Carlo","orcid":"https://orcid.org/0000-0002-4539-4758","observed_orcids":["https://orcid.org/0000-0002-4539-4758"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"America Vanoye-Carlo","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. america_vc@yahoo.com.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. america_vc@yahoo.com.mx","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078382501","display_name":"Gabriel L\u00f3pez\u2010Vel\u00e1zquez","orcid":"https://orcid.org/0000-0003-0470-1069","observed_orcids":["https://orcid.org/0000-0003-0470-1069"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Gabriel L\u00f3pez-Vel\u00e1zquez","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. glv_1999@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. glv_1999@yahoo.com","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075914124","display_name":"Gloria Hern\u00e1ndez\u2010Alc\u00e1ntara","orcid":"https://orcid.org/0000-0002-7029-6033","observed_orcids":["https://orcid.org/0000-0002-7029-6033"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Gloria Hern\u00e1ndez-Alc\u00e1ntara","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico","Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico. galcantara72@yahoo.com.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico D.F. 04510, Mexico. galcantara72@yahoo.com.mx","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018837516","display_name":"Jes\u00fas Oria\u2010Hern\u00e1ndez","orcid":"https://orcid.org/0000-0001-7147-1879","observed_orcids":["https://orcid.org/0000-0001-7147-1879"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Oria-Hern\u00e1ndez","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. joria@bq.unam.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. joria@bq.unam.mx","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047167859","display_name":"Horacio Reyes\u2010Vivas","orcid":"https://orcid.org/0000-0002-3604-9629","observed_orcids":["https://orcid.org/0000-0002-3604-9629"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Horacio Reyes-Vivas","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. hreyesvivas@yahoo.com.mx"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. hreyesvivas@yahoo.com.mx","institution_ids":["https://openalex.org/I4210146908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067012466","display_name":"Sergio Enr\u00edquez\u2010Flores","orcid":"https://orcid.org/0000-0003-2058-5707","observed_orcids":["https://orcid.org/0000-0003-2058-5707"]},"institutions":[{"id":"https://openalex.org/I4210146908","display_name":"Instituto Nacional de Pediatria","ror":"https://ror.org/05adj5455","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210146908"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Sergio Enr\u00edquez-Flores","raw_affiliation_strings":["Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. sergioenr@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico","institution_ids":["https://openalex.org/I4210146908"]},{"raw_affiliation_string":"Laboratorio de Bioqu\u00edmica Gen\u00e9tica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico D.F. 04530, Mexico. sergioenr@gmail.com","institution_ids":["https://openalex.org/I4210146908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039624943","https://openalex.org/A5067012466"],"corresponding_institution_ids":["https://openalex.org/I4210146908"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":4.9552,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.9493873,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"15","issue":"11","first_page":"21179","last_page":"21201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase","display_name":"glucose-6-phosphate dehydrogenase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/g6pd-deficiency","display_name":"glucose-6-phosphate dehydrogenase deficiency","score":0.9909999966621399},{"id":"https://openalex.org/keywords/g6pd-variants","display_name":"G6PD variants","score":0.906000018119812},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5320000052452087},{"id":"https://openalex.org/keywords/catalytic-constant","display_name":"catalytic rate constant","score":0.7139999866485596},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nadp-binding","display_name":"NADP+ binding","score":0.8370000123977661},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6439999938011169},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.4519999921321869},{"id":"https://openalex.org/keywords/hydrophobic-region","display_name":"hydrophobic region","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2779155592","wikidata":"https://www.wikidata.org/wiki/Q2403956","display_name":"Thermolabile","level":3,"score":0.887824535369873},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6732468605041504},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.5463611483573914},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5164799690246582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5093923211097717},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5025730133056641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4555867314338684},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4386879801750183},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4199543297290802},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3276641070842743},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.18392834067344666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1713862419128418}],"mesh":[{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005955","descriptor_name":"Glucosephosphate Dehydrogenase Deficiency","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005955","descriptor_name":"Glucosephosphate Dehydrogenase Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms151121179","doi":"https://doi.org/10.3390/ijms151121179","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151121179","pdf_url":"https://www.mdpi.com/1422-0067/15/11/21179/pdf?version=1416217314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3232893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4264219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25407525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25407525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4264219","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4264219/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.1948","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.1948","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/9f/ijms-15-21179.PMC4264219.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/ijms151121179","doi":"https://doi.org/10.3390/ijms151121179","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms151121179","pdf_url":"https://www.mdpi.com/1422-0067/15/11/21179/pdf?version=1416217314","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2248155325","display_name":null,"funder_award_id":"62321","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G3098834504","display_name":null,"funder_award_id":"154570","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G3777342321","display_name":null,"funder_award_id":"157863","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G7786328427","display_name":null,"funder_award_id":"106126","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070799178.pdf","grobid_xml":"https://content.openalex.org/works/W2070799178.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W104039999","https://openalex.org/W255996521","https://openalex.org/W1483242733","https://openalex.org/W1483928966","https://openalex.org/W1554607334","https://openalex.org/W1693303585","https://openalex.org/W1775749144","https://openalex.org/W1973473642","https://openalex.org/W1984335480","https://openalex.org/W2010612544","https://openalex.org/W2011533056","https://openalex.org/W2016372180","https://openalex.org/W2016851261","https://openalex.org/W2018778461","https://openalex.org/W2024828126","https://openalex.org/W2045942033","https://openalex.org/W2050599642","https://openalex.org/W2053735669","https://openalex.org/W2060656400","https://openalex.org/W2073698095","https://openalex.org/W2076283279","https://openalex.org/W2076849653","https://openalex.org/W2087539836","https://openalex.org/W2088888368","https://openalex.org/W2090096368","https://openalex.org/W2090860030","https://openalex.org/W2099227149","https://openalex.org/W2111967267","https://openalex.org/W2116137883","https://openalex.org/W2122238728","https://openalex.org/W2136789143","https://openalex.org/W2145866605","https://openalex.org/W2167598657","https://openalex.org/W2168413801","https://openalex.org/W2169004154","https://openalex.org/W4233690070","https://openalex.org/W4255063861","https://openalex.org/W4298337257"],"related_works":["https://openalex.org/W7100799295","https://openalex.org/W4282821872","https://openalex.org/W2189011477","https://openalex.org/W2620998207","https://openalex.org/W2302744968","https://openalex.org/W1973473642","https://openalex.org/W3016668097","https://openalex.org/W2407520947","https://openalex.org/W2167598657","https://openalex.org/W3020940442"],"abstract_inverted_index":{"Glucose-6-phosphate":[0],"dehydrogenase":[1],"(G6PD)":[2],"deficiency":[3,9],"is":[4,108,133],"the":[5,21,26,36,39,84,91,98,101,106,121,124,151,160,174,188,191,198,203],"most":[6,27,102],"common":[7],"enzyme":[8,209],"worldwide,":[10],"causing":[11],"a":[12,60],"wide":[13],"spectrum":[14],"of":[15,82,105,129,190,197,205],"conditions":[16],"with":[17,38,170],"severity":[18],"classified":[19],"from":[20,120],"mildest":[22],"(Class":[23,29],"IV)":[24],"to":[25,144,150,208],"severe":[28,146],"I).":[30],"To":[31],"correlate":[32],"mutation":[33],"sites":[34],"in":[35,90,187],"G6PD":[37,47],"resulting":[40],"phenotypes,":[41],"we":[42,58],"studied":[43,85],"four":[44],"naturally":[45],"occurring":[46],"variants:":[48],"Yucatan,":[49],"Nashville,":[50],"Valladolid":[51],"and":[52,68,74,100,114,136,163,200],"Mexico":[53],"City.":[54],"For":[55],"this":[56],"purpose,":[57],"developed":[59],"successful":[61],"over-expression":[62],"method":[63,71],"that":[64],"constitutes":[65],"an":[66],"easier":[67],"more":[69,145,168],"precise":[70],"for":[72,159],"obtaining":[73],"characterizing":[75],"these":[76],"enzymes.":[77],"The":[78,93,141,180],"k(cat)":[79],"(catalytic":[80],"constant)":[81],"all":[83],"variants":[86,177],"was":[87,156],"lower":[88],"than":[89],"wild-type.":[92],"structural":[94,152],"rigidity":[95],"might":[96],"be":[97,118],"cause":[99],"evident":[103],"consequence":[104],"mutations":[107,142,181],"their":[109],"impact":[110],"on":[111,138],"protein":[112,122],"stability":[113],"folding,":[115],"as":[116],"can":[117],"observed":[119,158],"yield,":[123],"T50":[125],"(temperature":[126],"where":[127],"50%":[128],"its":[130],"original":[131],"activity":[132],"retained)":[134],"values,":[135],"differences":[137],"hydrophobic":[139],"regions.":[140],"corresponding":[143],"phenotypes":[147],"are":[148],"related":[149],"NADP+":[153],"region.":[154],"This":[155],"clearly":[157],"Classes":[161],"III":[162],"II":[164],"variants,":[165],"which":[166],"became":[167],"thermostable":[169],"increasing":[171],"NADP+,":[172,206],"whereas":[173],"Class":[175],"I":[176],"remained":[178],"thermolabile.":[179],"produce":[182],"repulsive":[183],"electric":[184],"charges":[185],"that,":[186],"case":[189],"Yucatan":[192],"variant,":[193],"promote":[194],"increased":[195],"disorder":[196],"C-terminus":[199],"consequently":[201],"affect":[202],"binding":[204],"leading":[207],"instability.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}