{"id":"https://openalex.org/W2070745889","doi":"https://doi.org/10.1016/0022-1759(92)90273-v","title":"Molecular cloning of murine monoclonal anti-idiotypic Fab","display_name":"Molecular cloning of murine monoclonal anti-idiotypic Fab","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2070745889","doi":"https://doi.org/10.1016/0022-1759(92)90273-v","mag":"2070745889","pmid":"https://pubmed.ncbi.nlm.nih.gov/1383347"},"language":"en","primary_location":{"id":"doi:10.1016/0022-1759(92)90273-v","doi":"https://doi.org/10.1016/0022-1759(92)90273-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-1759(92)90273-v","pdf_url":null,"source":{"id":"https://openalex.org/S201669150","display_name":"Journal of Immunological Methods","issn_l":"0022-1759","issn":["0022-1759","1872-7905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunological Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yasushi Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasushi Kasai","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104","The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, Pa. 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, Pa. 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021976445","display_name":"Dorothee Herlyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothee Herlyn","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013158081","display_name":"Melinda Sperl\u00e1gh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Sperlagh","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079176935","display_name":"Haruhiko Maruyama","orcid":"https://orcid.org/0000-0001-6121-1387","observed_orcids":["https://orcid.org/0000-0001-6121-1387"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruhiko Maruyama","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102795999","display_name":"Shuzo Matsushita","orcid":"https://orcid.org/0000-0002-9649-8821","observed_orcids":["https://orcid.org/0000-0002-9649-8821"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuzo Matsushita","raw_affiliation_strings":["Kumamoto University Medical School, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University Medical School, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004235251","display_name":"Alban J. Linnenbach","orcid":"https://orcid.org/0000-0003-2215-381X","observed_orcids":["https://orcid.org/0000-0003-2215-381X"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alban J. Linnenbach","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, 36th and Spruce Streets, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004235251"],"corresponding_institution_ids":["https://openalex.org/I102322052"],"apc_list":{"value":2970,"currency":"USD","value_usd":2970},"apc_paid":null,"fwci":1.2868,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80726276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"155","issue":"1","first_page":"77","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6110000014305115},{"id":"https://openalex.org/keywords/idiotopes","display_name":"idiotopes","score":0.5339999794960022},{"id":"https://openalex.org/keywords/antibody-specificity","display_name":"antibody specificity","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C48660041","wikidata":"https://www.wikidata.org/wiki/Q5989022","display_name":"Idiotopes","level":5,"score":0.8995116949081421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.718599796295166},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6411698460578918},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6314291954040527},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.585910975933075},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5816941261291504},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5500893592834473},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47402527928352356},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.45018067955970764},{"id":"https://openalex.org/C2910693471","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody Repertoire","level":3,"score":0.4490531086921692},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42036813497543335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12742763757705688}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-1759(92)90273-v","doi":"https://doi.org/10.1016/0022-1759(92)90273-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-1759(92)90273-v","pdf_url":null,"source":{"id":"https://openalex.org/S201669150","display_name":"Journal of Immunological Methods","issn_l":"0022-1759","issn":["0022-1759","1872-7905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunological Methods","raw_type":"journal-article"},{"id":"pmid:1383347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1383347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunological methods","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2033619587","display_name":null,"funder_award_id":"AI25380-02","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2264817218","display_name":"ROLE OF HIV IN AIDS AND AIDS-ASSOCIATED NEOPLASMS","funder_award_id":"5p01ai025380-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3471318205","display_name":null,"funder_award_id":"CA-10815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000906427","display_name":"Consolidated Basic Cancer Research Program","funder_award_id":"P30CA010815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W159415807","https://openalex.org/W988335204","https://openalex.org/W1423281036","https://openalex.org/W1484092314","https://openalex.org/W1507403366","https://openalex.org/W1568767105","https://openalex.org/W1902227988","https://openalex.org/W1949747747","https://openalex.org/W1967604970","https://openalex.org/W1967704512","https://openalex.org/W1983649348","https://openalex.org/W1991593461","https://openalex.org/W2005516910","https://openalex.org/W2012736533","https://openalex.org/W2027559384","https://openalex.org/W2028309813","https://openalex.org/W2029067560","https://openalex.org/W2032118018","https://openalex.org/W2035209074","https://openalex.org/W2045498027","https://openalex.org/W2050717506","https://openalex.org/W2054592480","https://openalex.org/W2061530347","https://openalex.org/W2062235578","https://openalex.org/W2072742609","https://openalex.org/W2074122548","https://openalex.org/W2078837657","https://openalex.org/W2080580789","https://openalex.org/W2086373321","https://openalex.org/W2092415281","https://openalex.org/W2100837269","https://openalex.org/W2106709350","https://openalex.org/W2120513063","https://openalex.org/W2134812217","https://openalex.org/W2138270253","https://openalex.org/W2164768280","https://openalex.org/W2415881841","https://openalex.org/W2426766319","https://openalex.org/W2736943010","https://openalex.org/W4233138456","https://openalex.org/W4247638132","https://openalex.org/W4294216491","https://openalex.org/W6642434724"],"related_works":["https://openalex.org/W2039564984","https://openalex.org/W2004998754","https://openalex.org/W2304456955","https://openalex.org/W2081571586","https://openalex.org/W2046328398","https://openalex.org/W2055551298","https://openalex.org/W7099254195","https://openalex.org/W2142829679","https://openalex.org/W2354384113","https://openalex.org/W2032395182"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}