{"id":"https://openalex.org/W2070730833","doi":"https://doi.org/10.1002/tera.1093","title":"Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis","display_name":"Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2070730833","doi":"https://doi.org/10.1002/tera.1093","mag":"2070730833","pmid":"https://pubmed.ncbi.nlm.nih.gov/11835227"},"language":"en","primary_location":{"id":"doi:10.1002/tera.1093","doi":"https://doi.org/10.1002/tera.1093","is_oa":true,"landing_page_url":"https://doi.org/10.1002/tera.1093","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/tera.1093","source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/tera.1093","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081771204","display_name":"Hideki Fujita","orcid":"https://orcid.org/0000-0001-8657-0618","observed_orcids":["https://orcid.org/0000-0001-8657-0618"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Fujita","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026794757","display_name":"Rika Kosaki","orcid":"https://orcid.org/0000-0002-4367-6129","observed_orcids":["https://orcid.org/0000-0002-4367-6129"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210095856","display_name":"Saitama Children's Medical Center","ror":"https://ror.org/00smq1v26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210095856"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Kosaki","raw_affiliation_strings":["Department of Genetics, Saitama Children's Medical Center, Saitama, Japan","Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Saitama Children's Medical Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210095856"]},{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042748279","display_name":"Hiroshi Yoshihashi","orcid":"https://orcid.org/0000-0003-1727-625X","observed_orcids":["https://orcid.org/0000-0003-1727-625X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yoshihashi","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008536405","display_name":"Tsutomu Ogata","orcid":"https://orcid.org/0000-0001-7178-9991","observed_orcids":["https://orcid.org/0000-0001-7178-9991","https://orcid.org/0009-0001-4681-470X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Ogata","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015575713","display_name":"Masaru Tomita","orcid":"https://orcid.org/0000-0003-3423-377X","observed_orcids":["https://orcid.org/0000-0003-3423-377X"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4210141715","display_name":"Keio University Shonan Fujisawa","ror":"https://ror.org/047khpn70","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210141715"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Tomita","raw_affiliation_strings":["Laboratory for Bioinformatics, Keio University, Fujisawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bioinformatics, Keio University, Fujisawa, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4210141715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059324157","display_name":"Tomonobu Hasegawa","orcid":"https://orcid.org/0000-0002-0143-3989","observed_orcids":["https://orcid.org/0000-0002-0143-3989"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonobu Hasegawa","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105471199","display_name":"Takao Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Takahashi","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105841322","display_name":"Nobutake Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutake Matsuo","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","National Children's Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"National Children's Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088798513","display_name":"Kenjiro Kosaki","orcid":"https://orcid.org/0000-0002-6798-8151","observed_orcids":["https://orcid.org/0000-0002-6798-8151"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenjiro Kosaki","raw_affiliation_strings":["Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088798513"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":null,"apc_paid":null,"fwci":1.6199,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.82498521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"65","issue":"1","first_page":"10","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.5874000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.1421000063419342,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.14169999957084656,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-repressor","display_name":"AHRR","score":0.9860000014305115},{"id":"https://openalex.org/keywords/micropenis","display_name":"micropenis","score":0.996999979019165},{"id":"https://openalex.org/keywords/dioxin-exposure","display_name":"dioxin exposure","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor-nuclear-translocator","display_name":"ARNT","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ahr-signaling","display_name":"AhR signaling","score":0.6100000143051147},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-sequence-analysis","display_name":"gene sequence analysis","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8221455812454224},{"id":"https://openalex.org/C45815257","wikidata":"https://www.wikidata.org/wiki/Q109984923","display_name":"Aryl hydrocarbon receptor nuclear translocator","level":5,"score":0.7974294424057007},{"id":"https://openalex.org/C2779610619","wikidata":"https://www.wikidata.org/wiki/Q1471642","display_name":"Micropenis","level":3,"score":0.7472528219223022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6719197630882263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4765656292438507},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33491140604019165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2782006859779358},{"id":"https://openalex.org/C2777990738","wikidata":"https://www.wikidata.org/wiki/Q1132108","display_name":"Hypospadias","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/tera.1093","doi":"https://doi.org/10.1002/tera.1093","is_oa":true,"landing_page_url":"https://doi.org/10.1002/tera.1093","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/tera.1093","source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},{"id":"pmid:11835227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11835227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/tera.1093","doi":"https://doi.org/10.1002/tera.1093","is_oa":true,"landing_page_url":"https://doi.org/10.1002/tera.1093","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/tera.1093","source":{"id":"https://openalex.org/S4394736631","display_name":"Teratology","issn_l":"0040-3709","issn":["0040-3709","1096-9926"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9487000107765198,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320909","display_name":"Keio University","ror":"https://ror.org/02kn6nx58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070730833.pdf","grobid_xml":"https://content.openalex.org/works/W2070730833.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W632615820","https://openalex.org/W1592650154","https://openalex.org/W1785949966","https://openalex.org/W1807487415","https://openalex.org/W1963971496","https://openalex.org/W1967868552","https://openalex.org/W1971848731","https://openalex.org/W1980552888","https://openalex.org/W1982265633","https://openalex.org/W1983343541","https://openalex.org/W1987203718","https://openalex.org/W1990874048","https://openalex.org/W1993809284","https://openalex.org/W1995551499","https://openalex.org/W1995614751","https://openalex.org/W1998867972","https://openalex.org/W2002807152","https://openalex.org/W2008267067","https://openalex.org/W2009225735","https://openalex.org/W2020362416","https://openalex.org/W2021582762","https://openalex.org/W2022645849","https://openalex.org/W2022956461","https://openalex.org/W2023429295","https://openalex.org/W2024564719","https://openalex.org/W2033722975","https://openalex.org/W2036904490","https://openalex.org/W2059565720","https://openalex.org/W2067871613","https://openalex.org/W2071542986","https://openalex.org/W2075794433","https://openalex.org/W2076455484","https://openalex.org/W2077894760","https://openalex.org/W2081314586","https://openalex.org/W2082401857","https://openalex.org/W2087519438","https://openalex.org/W2090629019","https://openalex.org/W2097382368","https://openalex.org/W2100326496","https://openalex.org/W2100478222","https://openalex.org/W2103535380","https://openalex.org/W2110708324","https://openalex.org/W2130761174","https://openalex.org/W2133972226","https://openalex.org/W2138913971","https://openalex.org/W2139518310","https://openalex.org/W2158714788","https://openalex.org/W2160811937","https://openalex.org/W2162400904","https://openalex.org/W2165627850","https://openalex.org/W2394796557","https://openalex.org/W2404352341","https://openalex.org/W2522837470"],"related_works":["https://openalex.org/W2394599053","https://openalex.org/W2116231282","https://openalex.org/W2002396362","https://openalex.org/W2378346785","https://openalex.org/W2060058885","https://openalex.org/W2049881818","https://openalex.org/W1981300446","https://openalex.org/W2137671292","https://openalex.org/W2060065906","https://openalex.org/W2087122683"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genetic":[1],"background":[2],"of":[3,28,90,94,104,109,115,130,147,199,206,228,234,241,251],"a":[4,64,92,235],"fetus":[5,236],"contributes":[6],"to":[7,19,57,74,177,237],"the":[8,33,76,82,88,101,110,116,127,137,140,143,169,186,190,207,225,232,238,248],"abnormal":[9],"development":[10],"after":[11],"teratogen":[12],"exposure.":[13],"In":[14,48],"rodents,":[15],"in":[16,59,69,152,215,244],"utero":[17],"exposure":[18,243],"dioxins":[20,29],"affects":[21],"male":[22],"external":[23],"genital":[24],"development.":[25],"The":[26,160,180],"effects":[27,240],"are":[30],"mediated":[31],"via":[32],"aryl":[34,42,50],"hydrocarbon":[35,43,51],"receptor":[36,44,52],"(AHR)":[37],"and":[38,80,87,99,142,156,168,189,203],"its":[39],"binding":[40],"protein,":[41],"nuclear":[45],"translocator":[46],"(ARNT).":[47],"mice,":[49],"repressor":[53],"(AHRR),":[54],"which":[55],"binds":[56],"ARNT":[58],"competition":[60],"with":[61,154,201],"AHR,":[62],"plays":[63],"critical":[65],"negative":[66],"regulatory":[67],"role":[68],"AHR":[70],"signaling.":[71,253],"We":[72,97],"attempt":[73],"characterize":[75],"human":[77,102,117,132,164],"AHRR":[78,85,123,165,171,229],"gene":[79],"investigate":[81],"relationship":[83],"between":[84,139,185],"polymorphisms":[86],"incidence":[89],"micropenis,":[91],"phenotype":[93],"undermasculinization.":[95],"METHODS:":[96],"identified":[98,184],"characterized":[100],"homolog":[103],"mouse":[105,170],"AHRR,":[106],"taking":[107],"advantage":[108],"publicly":[111],"available":[112],"draft":[113],"version":[114],"genome":[118],"sequence.":[119],"After":[120],"detecting":[121],"an":[122],"protein":[124,172],"polymorphism":[125,141,182],"by":[126],"direct":[128],"sequencing":[129],"pooled":[131],"genomic":[133],"DNA,":[134],"we":[135],"evaluated":[136],"association":[138],"presence":[144],"or":[145],"absence":[146],"micropenis":[148,155,202],"(<":[149],"-2.5":[150],"SD)":[151],"patients":[153,200],"control":[157],"subjects.":[158],"RESULTS:":[159],"deduced":[161],"sequence":[162,175],"for":[163,211,224],"(715":[166],"residues)":[167],"exhibited":[173],"81%":[174],"homology":[176],"each":[178],"other.":[179],"Pro185Ala":[181],"was":[183,217],"PAS-A":[187],"region":[188],"highly":[191],"conserved":[192],"arginine/cysteine-rich":[193],"RCFRCRL/VRC":[194],"region.":[195],"Forty-six":[196],"percent":[197],"(27/59)":[198],"27%":[204],"(22/80)":[205],"controls":[208],"were":[209],"homozygous":[210],"185Pro;":[212],"this":[213],"difference":[214],"frequencies":[216],"significant":[218],"(P":[219],"=":[220],"0.03).":[221],"CONCLUSIONS:":[222],"Homozygosity":[223],"185Pro":[226],"allele":[227],"may":[230],"increase":[231],"susceptibility":[233],"undermasculinizing":[239],"dioxin":[242],"utero,":[245],"presumably":[246],"through":[247],"diminished":[249],"inhibition":[250],"AHR-mediated":[252]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-10-10T00:00:00"}
