{"id":"https://openalex.org/W2070569107","doi":"https://doi.org/10.1038/nm.2430","title":"Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells","display_name":"Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells","publication_year":2011,"publication_date":"2011-09-25","ids":{"openalex":"https://openalex.org/W2070569107","doi":"https://doi.org/10.1038/nm.2430","mag":"2070569107","pmid":"https://pubmed.ncbi.nlm.nih.gov/21946537","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192247"},"language":"en","primary_location":{"id":"doi:10.1038/nm.2430","doi":"https://doi.org/10.1038/nm.2430","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm.2430","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192247","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Barthelemy Diouf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barthelemy Diouf","raw_affiliation_strings":["Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qing Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Cheng","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009358670","display_name":"Natalia F. Krynetskaia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia F Krynetskaia","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035759509","display_name":"Wenjian Yang","orcid":"https://orcid.org/0000-0002-7305-5649","observed_orcids":["https://orcid.org/0000-0002-7305-5649"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjian Yang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077339582","display_name":"Meyling Hua-Chen Cheok","orcid":"https://orcid.org/0000-0002-7820-8026","observed_orcids":["https://orcid.org/0000-0002-7820-8026"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meyling Cheok","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112528708","display_name":"Deqing Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deqing Pei","raw_affiliation_strings":["Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026730026","display_name":"Yiping Fan","orcid":"https://orcid.org/0000-0002-8430-4620","observed_orcids":["https://orcid.org/0000-0002-8430-4620"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiping Fan","raw_affiliation_strings":["Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349405","display_name":"Cheng Cheng","orcid":"https://orcid.org/0000-0002-5367-3618","observed_orcids":["https://orcid.org/0000-0002-5367-3618"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Cheng","raw_affiliation_strings":["Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036222375","display_name":"Evgeny Y. Krynetskiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evgeny Y Krynetskiy","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762929","display_name":"Hui Zhi Geng","orcid":"https://orcid.org/0000-0001-7787-9664","observed_orcids":["https://orcid.org/0000-0001-7787-9664"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Geng","raw_affiliation_strings":["Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762806","display_name":"Siying Chen","orcid":"https://orcid.org/0000-0002-9563-2726","observed_orcids":["https://orcid.org/0000-0002-9563-2726"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siying Chen","raw_affiliation_strings":["Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009750006","display_name":"William E. Thierfelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Thierfelder","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048744038","display_name":"Charles Grenfell Mullighan","orcid":"https://orcid.org/0000-0002-1871-1850","observed_orcids":["https://orcid.org/0000-0002-1871-1850"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles G Mullighan","raw_affiliation_strings":["Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015143631","display_name":"James R. Downing","orcid":"https://orcid.org/0009-0004-4853-7672","observed_orcids":["https://orcid.org/0009-0004-4853-7672"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R Downing","raw_affiliation_strings":["Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103435215","display_name":"Peggy Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Hsieh","raw_affiliation_strings":["Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health (NIH), Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018363328","display_name":"Ching\u2010Hon Pui","orcid":"https://orcid.org/0000-0003-0303-5658","observed_orcids":["https://orcid.org/0000-0003-0303-5658"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching-Hon Pui","raw_affiliation_strings":["Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009866488","display_name":"Mary V. Relling","orcid":"https://orcid.org/0000-0002-3720-9591","observed_orcids":["https://orcid.org/0000-0002-3720-9591"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary V Relling","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034189317","display_name":"William Edward Evans","orcid":"https://orcid.org/0000-0002-9333-5322","observed_orcids":["https://orcid.org/0000-0002-9333-5322"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William E Evans","raw_affiliation_strings":["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034189317"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.129,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.95298171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"17","issue":"10","first_page":"1298","last_page":"1303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.16359999775886536,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9399999976158142},{"id":"https://openalex.org/keywords/somatic-deletions","display_name":"somatic deletions","score":0.8859999775886536},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6520000100135803},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/thiopurine-resistance","display_name":"thiopurine resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.8830000162124634},{"id":"https://openalex.org/keywords/herc1","display_name":"HERC1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-kinase-c-zeta","display_name":"protein kinase C zeta","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pik3c2b","display_name":"PIK3C2B","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.9505860805511475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6233477592468262},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6062653660774231},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.597576916217804},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5388950705528259},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4891217350959778},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.45793819427490234},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.44061803817749023},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41602396965026855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35637450218200684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29321610927581787},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.0652221143245697}],"mesh":[{"descriptor_ui":"D000099221","descriptor_name":"Protein Kinase C zeta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013866","descriptor_name":"Thioguanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053843","descriptor_name":"DNA Mismatch Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058541","descriptor_name":"Class II Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nm.2430","doi":"https://doi.org/10.1038/nm.2430","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nm.2430","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:21946537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21946537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2317194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192247","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3192247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2317194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192247","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1976482914","display_name":"PAAR4Kids-Pharmacogenomics of Anticancer Agents Research in Children","funder_award_id":"U01GM092666","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7777329513","display_name":"PHARMACOGENOMICS OF CHILDHOOD LEUKEMIA (ALL)","funder_award_id":"R37CA036401","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W41706551","https://openalex.org/W1606652321","https://openalex.org/W1660548053","https://openalex.org/W1945650577","https://openalex.org/W1972254989","https://openalex.org/W1974292630","https://openalex.org/W1977284533","https://openalex.org/W1977354865","https://openalex.org/W1977492313","https://openalex.org/W1978014329","https://openalex.org/W1980462742","https://openalex.org/W1984065010","https://openalex.org/W1984412362","https://openalex.org/W1987587656","https://openalex.org/W1996860480","https://openalex.org/W1998792400","https://openalex.org/W2007276591","https://openalex.org/W2043082494","https://openalex.org/W2061032790","https://openalex.org/W2074451273","https://openalex.org/W2074581933","https://openalex.org/W2077217951","https://openalex.org/W2077990737","https://openalex.org/W2089190709","https://openalex.org/W2095692554","https://openalex.org/W2098441538","https://openalex.org/W2103304405","https://openalex.org/W2110922298","https://openalex.org/W2115820946","https://openalex.org/W2127590767","https://openalex.org/W2142136137","https://openalex.org/W2163382569","https://openalex.org/W2168804588","https://openalex.org/W2206735890","https://openalex.org/W2231077424","https://openalex.org/W4232414730"],"related_works":["https://openalex.org/W2041599447","https://openalex.org/W1967205646","https://openalex.org/W2329536997","https://openalex.org/W7096589392","https://openalex.org/W2611346664","https://openalex.org/W2020643908","https://openalex.org/W2789860721","https://openalex.org/W53029219","https://openalex.org/W2095521135","https://openalex.org/W2206735890"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}