{"id":"https://openalex.org/W2070549545","doi":"https://doi.org/10.1016/0167-4781(93)90147-6","title":"ATP-independent DNA topoisomerase from Fervidobacterium islandicum","display_name":"ATP-independent DNA topoisomerase from Fervidobacterium islandicum","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2070549545","doi":"https://doi.org/10.1016/0167-4781(93)90147-6","mag":"2070549545","pmid":"https://pubmed.ncbi.nlm.nih.gov/8241262"},"language":"en","primary_location":{"id":"doi:10.1016/0167-4781(93)90147-6","doi":"https://doi.org/10.1016/0167-4781(93)90147-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4781(93)90147-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210212269","display_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","issn_l":"0167-4781","issn":["0167-4781","1879-2634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075012431","display_name":"Claire Bouthier de la Tour","orcid":"https://orcid.org/0000-0002-8515-0088","observed_orcids":["https://orcid.org/0000-0002-8515-0088"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Bouthier de la Tour","raw_affiliation_strings":["Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072233293","display_name":"Christiane Portemer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christiane Portemer","raw_affiliation_strings":["Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091702193","display_name":"Patrick Forterre","orcid":"https://orcid.org/0000-0002-1843-7214","observed_orcids":["https://orcid.org/0000-0002-1843-7214"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Forterre","raw_affiliation_strings":["Laboratoire des Archaebact\u00e9ries, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire des Archaebact\u00e9ries, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103576469","display_name":"Robert Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Huber","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Genetik und Mikrobiologie, Universit\u00e4t Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Genetik und Mikrobiologie, Universit\u00e4t Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071251735","display_name":"Michel Duguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Duguet","raw_affiliation_strings":["Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie des Acides Nucl\u00e9iques, Institut de G\u00e9n\u00e9tique et Microbiologie, URA 1354 Centre National de la Recherche Scientifique, Universit\u00e9 Paris-Sud, Orsay France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8713,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.70771028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1216","issue":"2","first_page":"213","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermotogales","display_name":"Thermotogales","score":0.9020000100135803},{"id":"https://openalex.org/keywords/thermophilic-bacteria","display_name":"thermophilic bacteria","score":0.949999988079071},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.7580000162124634},{"id":"https://openalex.org/keywords/enzyme-characterization","display_name":"enzyme characterization","score":0.6740000247955322},{"id":"https://openalex.org/keywords/magnesium-dependence","display_name":"magnesium dependence","score":0.6259999871253967},{"id":"https://openalex.org/keywords/dna-supercoiling","display_name":"DNA supercoiling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7033282518386841},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4560612738132477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39697209000587463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35187482833862305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3408939242362976},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3267252445220947}],"mesh":[{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004278","descriptor_name":"DNA, Superhelical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013822","descriptor_name":"Thermoplasma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0167-4781(93)90147-6","doi":"https://doi.org/10.1016/0167-4781(93)90147-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-4781(93)90147-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210212269","display_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","issn_l":"0167-4781","issn":["0167-4781","1879-2634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","raw_type":"journal-article"},{"id":"pmid:8241262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8241262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1168425332","https://openalex.org/W1516666607","https://openalex.org/W1531390121","https://openalex.org/W1541526229","https://openalex.org/W1557336515","https://openalex.org/W1611482599","https://openalex.org/W1636605543","https://openalex.org/W1758664125","https://openalex.org/W1923326679","https://openalex.org/W1958616440","https://openalex.org/W1971425374","https://openalex.org/W1974470327","https://openalex.org/W1982671700","https://openalex.org/W1989054182","https://openalex.org/W1994279558","https://openalex.org/W2003539081","https://openalex.org/W2018589873","https://openalex.org/W2022961230","https://openalex.org/W2029177968","https://openalex.org/W2036903769","https://openalex.org/W2060910291","https://openalex.org/W2072541043","https://openalex.org/W2074194645","https://openalex.org/W2074654806","https://openalex.org/W2082497364","https://openalex.org/W2100837269","https://openalex.org/W2147746526","https://openalex.org/W2167128189","https://openalex.org/W2180865317","https://openalex.org/W2254338983","https://openalex.org/W4211022623","https://openalex.org/W4233567369","https://openalex.org/W4242306912"],"related_works":["https://openalex.org/W1528664360","https://openalex.org/W143563547","https://openalex.org/W2254338983","https://openalex.org/W2010007623","https://openalex.org/W1505792072","https://openalex.org/W1492302002","https://openalex.org/W2005603626","https://openalex.org/W64233274","https://openalex.org/W2077731224","https://openalex.org/W2784013959"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}