{"id":"https://openalex.org/W2070524394","doi":"https://doi.org/10.1105/tpc.109.068593","title":"Feedback Inhibition of Ammonium Uptake by a Phospho-Dependent Allosteric Mechanism in Arabidopsis","display_name":"Feedback Inhibition of Ammonium Uptake by a Phospho-Dependent Allosteric Mechanism in Arabidopsis","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W2070524394","doi":"https://doi.org/10.1105/tpc.109.068593","mag":"2070524394","pmid":"https://pubmed.ncbi.nlm.nih.gov/19948793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2798313"},"language":"en","primary_location":{"id":"doi:10.1105/tpc.109.068593","doi":"https://doi.org/10.1105/tpc.109.068593","is_oa":false,"landing_page_url":"https://doi.org/10.1105/tpc.109.068593","pdf_url":null,"source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2798313","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037965981","display_name":"Viviane Lanquar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viviane Lanquar","raw_affiliation_strings":["Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]},{"raw_affiliation_string":"aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067437883","display_name":"Dominique Loqu\u00e9","orcid":"https://orcid.org/0000-0002-2060-6611","observed_orcids":["https://orcid.org/0000-0002-2060-6611"]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominique Loque\u0301","raw_affiliation_strings":["Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]},{"raw_affiliation_string":"aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032048653","display_name":"Friederike H\u00f6rmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Friederike Ho\u0308rmann","raw_affiliation_strings":["Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]},{"raw_affiliation_string":"aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028854077","display_name":"Lixing Yuan","orcid":"https://orcid.org/0000-0003-0233-6184","observed_orcids":["https://orcid.org/0000-0003-0233-6184"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixing Yuan","raw_affiliation_strings":["Key Lab of Plant Nutrition, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China","bKey Lab of Plant Nutrition, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Plant Nutrition, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"bKey Lab of Plant Nutrition, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045263217","display_name":"Anne Bohner","orcid":"https://orcid.org/0000-0002-2431-101X","observed_orcids":["https://orcid.org/0000-0002-2431-101X"]},"institutions":[{"id":"https://openalex.org/I4210127902","display_name":"Leibniz-Institut f\u00fcr Pflanzengenetik und Kulturpflanzenforschung (IPK)","ror":"https://ror.org/02skbsp27","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Bohner","raw_affiliation_strings":["Molecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","cMolecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","institution_ids":["https://openalex.org/I4210127902"]},{"raw_affiliation_string":"cMolecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","institution_ids":["https://openalex.org/I4210127902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039163186","display_name":"Wolfgang R. Engelsberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang R. Engelsberger","raw_affiliation_strings":["Max Planck Institut fu\u0308r Molekulare Pflanzenphysiologie, 14476 Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institut fu\u0308r Molekulare Pflanzenphysiologie, 14476 Golm, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043281640","display_name":"Sylvie Lalonde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvie Lalonde","raw_affiliation_strings":["Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]},{"raw_affiliation_string":"aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090816444","display_name":"Waltraud X. Schulze","orcid":"https://orcid.org/0000-0001-9957-7245","observed_orcids":["https://orcid.org/0000-0001-9957-7245"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Waltraud X. Schulze","raw_affiliation_strings":["Max Planck Institut fu\u0308r Molekulare Pflanzenphysiologie, 14476 Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institut fu\u0308r Molekulare Pflanzenphysiologie, 14476 Golm, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077632348","display_name":"Nicolaus Von Wir\u00e9n A","orcid":"https://orcid.org/0000-0002-4966-425X","observed_orcids":["https://orcid.org/0000-0002-4966-425X"]},"institutions":[{"id":"https://openalex.org/I4210127902","display_name":"Leibniz-Institut f\u00fcr Pflanzengenetik und Kulturpflanzenforschung (IPK)","ror":"https://ror.org/02skbsp27","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicolaus von Wire\u0301n","raw_affiliation_strings":["Molecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","cMolecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","institution_ids":["https://openalex.org/I4210127902"]},{"raw_affiliation_string":"cMolecular Plant Nutrition, Leibniz-Institute for Plant Genetics and Crop Plant Research, 06466 Gatersleben, Germany","institution_ids":["https://openalex.org/I4210127902"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078963967","display_name":"Wolf Bernd Frommer","orcid":"https://orcid.org/0000-0001-6465-0115","observed_orcids":["https://orcid.org/0000-0001-6465-0115","https://orcid.org/0000-0002-7622-1139"]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210095419","display_name":"Carnegie Department of Plant Biology","ror":"https://ror.org/00tdyb139","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolf B. Frommer","raw_affiliation_strings":["Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]},{"raw_affiliation_string":"aDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210095419"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4934,"currency":"USD","value_usd":4934},"apc_paid":null,"fwci":14.5354,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.99078364,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"21","issue":"11","first_page":"3610","last_page":"3622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12566","display_name":"Nitrogen and Sulfur Effects on Brassica","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonium-uptake","display_name":"ammonium uptake","score":0.9120000004768372},{"id":"https://openalex.org/keywords/amt1","display_name":"AMT1","score":0.878000020980835},{"id":"https://openalex.org/keywords/ammonium-transporters","display_name":"ammonium transporters","score":0.7689999938011169},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.6209999918937683},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.6980000138282776},{"id":"https://openalex.org/keywords/trimeric-complex","display_name":"trimeric complex","score":0.753000020980835},{"id":"https://openalex.org/keywords/transceptors","display_name":"transceptors","score":0.5989999771118164},{"id":"https://openalex.org/keywords/ammonium-sensing","display_name":"ammonium sensing","score":0.6489999890327454},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.7159203886985779},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.6668805480003357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6619092226028442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.626035749912262},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5663881301879883},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5590930581092834},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5315777063369751},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5101912021636963},{"id":"https://openalex.org/C190114821","wikidata":"https://www.wikidata.org/wiki/Q412861","display_name":"Permease","level":4,"score":0.4942322075366974},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.4739256799221039},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4670984148979187},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4585845470428467},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.4435846507549286},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4422123432159424},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.43033531308174133},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.40469491481781006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21828526258468628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18599167466163635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1272895634174347},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06616833806037903},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010758","descriptor_name":"Phosphorus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017660","descriptor_name":"Autoreceptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1105/tpc.109.068593","doi":"https://doi.org/10.1105/tpc.109.068593","is_oa":false,"landing_page_url":"https://doi.org/10.1105/tpc.109.068593","pdf_url":null,"source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2798313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2798313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell","raw_type":"Text"},{"id":"pmid:19948793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19948793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant cell","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:460019","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/460019","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plant Cell, v.21, 3610-3622 (2009)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1815478","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0014-2570-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plant Cell","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2798313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2798313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1254580001","https://openalex.org/W1613664118","https://openalex.org/W1942398216","https://openalex.org/W1967831157","https://openalex.org/W1969355717","https://openalex.org/W1978319589","https://openalex.org/W1983589176","https://openalex.org/W1993089190","https://openalex.org/W1995087505","https://openalex.org/W1997490422","https://openalex.org/W2000349773","https://openalex.org/W2002158823","https://openalex.org/W2003037782","https://openalex.org/W2005399896","https://openalex.org/W2007866476","https://openalex.org/W2014795460","https://openalex.org/W2016383559","https://openalex.org/W2027284523","https://openalex.org/W2037338352","https://openalex.org/W2042380638","https://openalex.org/W2042717435","https://openalex.org/W2047783119","https://openalex.org/W2048407980","https://openalex.org/W2051234617","https://openalex.org/W2053304217","https://openalex.org/W2058042460","https://openalex.org/W2060369427","https://openalex.org/W2061052519","https://openalex.org/W2068073478","https://openalex.org/W2069261055","https://openalex.org/W2070102480","https://openalex.org/W2071330316","https://openalex.org/W2073563030","https://openalex.org/W2074369001","https://openalex.org/W2075015345","https://openalex.org/W2084304818","https://openalex.org/W2085233887","https://openalex.org/W2091964834","https://openalex.org/W2097971260","https://openalex.org/W2099682053","https://openalex.org/W2104726963","https://openalex.org/W2106450047","https://openalex.org/W2110948886","https://openalex.org/W2113929848","https://openalex.org/W2114782850","https://openalex.org/W2119670501","https://openalex.org/W2121168360","https://openalex.org/W2122436542","https://openalex.org/W2126292296","https://openalex.org/W2128711916","https://openalex.org/W2129558617","https://openalex.org/W2131696350","https://openalex.org/W2133653666","https://openalex.org/W2139571132","https://openalex.org/W2153777219","https://openalex.org/W2158720490","https://openalex.org/W2159552127","https://openalex.org/W2164234055","https://openalex.org/W2168421316","https://openalex.org/W2168847574","https://openalex.org/W2169039196","https://openalex.org/W2169568332","https://openalex.org/W2170023485","https://openalex.org/W2171968158","https://openalex.org/W2239384431","https://openalex.org/W2478878809"],"related_works":["https://openalex.org/W2946583433","https://openalex.org/W2001813373","https://openalex.org/W2128876341","https://openalex.org/W7221347490","https://openalex.org/W2058042460","https://openalex.org/W7221529886","https://openalex.org/W2586703685","https://openalex.org/W3127888658","https://openalex.org/W2053304217","https://openalex.org/W4384922772"],"abstract_inverted_index":{"The":[0,32],"acquisition":[1,26],"of":[2,51,79,88,93,102,147,160,184,192],"nutrients":[3],"requires":[4],"tight":[5],"regulation":[6,56],"to":[7,14,91,139,151,169],"ensure":[8],"optimal":[9],"supply":[10,193],"while":[11],"preventing":[12],"accumulation":[13,120],"toxic":[15],"levels.":[16],"Ammonium":[17],"transporter/methylamine":[18],"permease/rhesus":[19],"(AMT/Mep/Rh)":[20],"transporters":[21],"are":[22],"responsible":[23],"for":[24,53],"ammonium":[25,33,107,119,132,141,156,161,176],"in":[27,71,75,85,108,123,143,149,154,171],"bacteria,":[28],"fungi,":[29],"and":[30,111,207],"plants.":[31],"transporter":[34,133,206],"AMT1;1":[35],"from":[36],"Arabidopsis":[37,164],"thaliana":[38],"uses":[39],"a":[40,49,60,67,72,109,172,189,203],"novel":[41,179],"regulatory":[42],"mechanism":[43,181],"requiring":[44],"the":[45,76,80,94,131,144],"productive":[46],"interaction":[47],"between":[48],"trimer":[50],"subunits":[52],"function.":[54],"Allosteric":[55],"is":[57,104,182],"mediated":[58,201],"by":[59,106,202],"cytosolic":[61],"C-terminal":[62],"trans-activation":[63],"domain,":[64],"which":[65],"carries":[66],"conserved":[68],"Thr":[69],"(T460)":[70],"critical":[73],"position":[74],"hinge":[77],"region":[78],"C":[81],"terminus.":[82],"When":[83],"expressed":[84],"yeast,":[86],"mutation":[87],"T460":[89,103,148],"leads":[90],"inactivation":[92],"trimeric":[95],"complex.":[96],"This":[97,178],"study":[98],"shows":[99],"that":[100,127],"phosphorylation":[101,167],"triggered":[105],"time-":[110],"concentration-dependent":[112],"manner.":[113],"Neither":[114],"Gln":[115],"nor":[116],"l-methionine":[117],"sulfoximine-induced":[118],"were":[121],"effective":[122],"inducing":[124],"phosphorylation,":[125],"suggesting":[126],"roots":[128],"use":[129],"either":[130],"itself":[134],"or":[135],"another":[136],"extracellular":[137,197],"sensor":[138],"measure":[140],"concentrations":[142],"rhizosphere.":[145],"Phosphorylation":[146],"response":[150],"an":[152,196],"increase":[153],"external":[155],"correlates":[157],"with":[158],"inhibition":[159],"uptake":[162,186],"into":[163],"roots.":[165],"Thus,":[166],"appears":[168],"function":[170],"feedback":[173],"loop":[174],"restricting":[175],"uptake.":[177],"autoregulatory":[180],"capable":[183],"tuning":[185],"capacity":[187],"over":[188],"wide":[190],"range":[191],"levels":[194],"using":[195],"sensory":[198],"system,":[199],"potentially":[200],"transceptor":[204],"(i.e.,":[205],"receptor).":[208]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}