{"id":"https://openalex.org/W2070522870","doi":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","title":"Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity","display_name":"Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W2070522870","doi":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","mag":"2070522870","pmid":"https://pubmed.ncbi.nlm.nih.gov/2297637"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900201%2965%3A3%3C466%3A%3AAID-CNCR2820650315%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900201%2965%3A3%3C466%3A%3AAID-CNCR2820650315%3E3.0.CO%3B2-Q","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021468732","display_name":"C. Bethan Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bethan Powell","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110","Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076087889","display_name":"David Gardner Mutch","orcid":"https://orcid.org/0000-0002-6921-1581","observed_orcids":["https://orcid.org/0000-0002-6921-1581"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Mutch","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108384922","display_name":"Ming-Shian Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Shian Kao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065702464","display_name":"Janet Wen-Yun Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Wen-Yun Kao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090306304","display_name":"Deanne L. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanne L. Perry","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005079266","display_name":"Eileen M. Westphale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen Westphale","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103428006","display_name":"John Leslie Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Leslie Collins","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Oncology Division, Washington University School of Medicine, Saint Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103428006"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.1643,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.46713672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"65","issue":"3","first_page":"466","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.1386999934911728,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chemotherapy-induced-immunosuppression","display_name":"chemotherapy-induced immunosuppression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/antiemetics","display_name":"antiemetics","score":0.6600000262260437},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.6880000233650208},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/in-vitro-cytotoxicity","display_name":"in vitro cytotoxicity","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.9666017293930054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7910840511322021},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7774975299835205},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.6868420243263245},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.650407612323761},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4858824610710144},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45085543394088745},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.45080724358558655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4419018626213074},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4236431419849396},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39788976311683655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3710636496543884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13731664419174194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06759637594223022},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900201%2965%3A3%3C466%3A%3AAID-CNCR2820650315%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2297637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2297637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","doi":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19900201)65:3<466::aid-cncr2820650315>3.0.co;2-q","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819900201%2965%3A3%3C466%3A%3AAID-CNCR2820650315%3E3.0.CO%3B2-Q","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070522870.pdf","grobid_xml":"https://content.openalex.org/works/W2070522870.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1548155696","https://openalex.org/W1559184092","https://openalex.org/W1664574339","https://openalex.org/W1782640926","https://openalex.org/W1831313435","https://openalex.org/W1954901676","https://openalex.org/W1977926796","https://openalex.org/W1983362081","https://openalex.org/W1992378118","https://openalex.org/W2004754540","https://openalex.org/W2005526242","https://openalex.org/W2024463338","https://openalex.org/W2055499537","https://openalex.org/W2099693096","https://openalex.org/W2132910786","https://openalex.org/W2167434686","https://openalex.org/W2419151418","https://openalex.org/W2892541314","https://openalex.org/W2894003978","https://openalex.org/W4313313341"],"related_works":["https://openalex.org/W2180449971","https://openalex.org/W2417648434","https://openalex.org/W2398724826","https://openalex.org/W2411404796","https://openalex.org/W1976554239","https://openalex.org/W2003096753","https://openalex.org/W1997357590","https://openalex.org/W2240817105","https://openalex.org/W2404205726","https://openalex.org/W2058135130"],"abstract_inverted_index":{"Because":[0],"dexamethasone":[1,45,73,92,124,138,147,174,199,225,237],"is":[2,242],"often":[3],"included":[4,72,177],"as":[5],"an":[6],"antiemetic":[7],"in":[8,23,46,108,118,139,152,164,178,204,216,238],"chemotherapy":[9,52,69,180,240],"protocols":[10,70,241],"that":[11,60,71,140,198,230],"involve":[12],"cisplatin":[13,16],"and":[14,163],"because":[15],"has":[17,218],"been":[18,156,220],"shown":[19],"to":[20,97,106],"increase":[21],"the":[22,37,61,98,107,141,170,179,182,208,222,234],"vitro":[24,109],"lysis":[25],"of":[26,40,56,64,91,101,111,137,143,185,212,224,233,236],"tumor":[27,209],"cells":[28,215,228],"by":[29,146],"natural":[30],"cytotoxic":[31],"(NC)":[32],"effector":[33],"cells,":[34],"we":[35],"determined":[36],"NC":[38,62,112,119,144,183,205,214,227],"activity":[39,63,113,120,145,184],"27":[41],"patients":[42,65,102,153,165,187],"who":[43,66,154,166],"received":[44,67],"conjunction":[47],"with":[48,82,104,122],"seven":[49],"different":[50,151],"cisplatin-based":[51,68,239],"protocols.":[53],"The":[54,89],"results":[55,196],"this":[57],"analysis":[58],"showed":[59],"was":[74,125,133,148,175,188],"reduced":[75,190],"significantly":[76,150],"24":[77,191],"hours":[78,192],"after":[79,193],"treatment":[80,84],"compared":[81,121],"before":[83],"(P":[85,128],"less":[86,129],"than":[87,130],"0.001).":[88,131],"addition":[90],"(at":[93],"a":[94,115,201],"concentration":[95],"equivalent":[96],"plasma":[99],"level":[100],"treated":[103,157,168],"dexamethasone)":[105],"assay":[110],"caused":[114],"significant":[116,202],"decrease":[117],"when":[123],"not":[126,149,176,189,219],"added":[127],"There":[132],"no":[134],"cumulative":[135],"effect":[136,223,235],"reduction":[142,203],"had":[155],"previously":[158],"at":[159],"least":[160],"four":[161],"times":[162],"were":[167],"for":[169],"first":[171],"time.":[172],"When":[173],"protocol":[181],"19":[186],"treatment.":[194],"These":[195],"indicate":[197],"causes":[200],"activity.":[206],"Although":[207],"surveillance":[210],"role":[211],"human":[213],"vivo":[217],"established,":[221],"on":[226],"suggests":[229],"additional":[231],"research":[232],"warranted.":[243]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}