{"id":"https://openalex.org/W2070475623","doi":"https://doi.org/10.1249/01.mss.0000354760.94691.16","title":"Increased Fitness Attenuates Endothelial Dysfunction Following A High Fat Meal In Postmenopausal Women","display_name":"Increased Fitness Attenuates Endothelial Dysfunction Following A High Fat Meal In Postmenopausal Women","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2070475623","doi":"https://doi.org/10.1249/01.mss.0000354760.94691.16","mag":"2070475623"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000354760.94691.16","doi":"https://doi.org/10.1249/01.mss.0000354760.94691.16","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000354760.94691.16","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012176769","display_name":"Damon Leo Swift","orcid":"https://orcid.org/0000-0001-6223-6930","observed_orcids":["https://orcid.org/0000-0001-6223-6930"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damon L. Swift","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020293330","display_name":"Siddhartha S. Angadi","orcid":"https://orcid.org/0000-0002-2932-7926","observed_orcids":["https://orcid.org/0000-0002-2932-7926"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhartha S. Angadi","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085252","display_name":"Judith Y. Weltman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Y. Weltman","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046840650","display_name":"Eugene J. Barrett","orcid":"https://orcid.org/0000-0003-0689-4044","observed_orcids":["https://orcid.org/0000-0003-0689-4044"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene J. Barret","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012190278","display_name":"James T. Patrie","orcid":"https://orcid.org/0000-0001-7392-830X","observed_orcids":["https://orcid.org/0000-0001-7392-830X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Patrie","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075954553","display_name":"Glenn A. Gaesser","orcid":"https://orcid.org/0000-0001-5127-5336","observed_orcids":["https://orcid.org/0000-0001-5127-5336"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn A. Gaesser","raw_affiliation_strings":["University of Virginia, Charlottesville, VA","(No relationships reported)","(Sponsor: Dr. Arthur Weltman, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"(Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047868387","display_name":"ARTHUR L. WELTMAN","orcid":"https://orcid.org/0000-0002-0125-3769","observed_orcids":["https://orcid.org/0000-0002-0125-3769"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Weltman","raw_affiliation_strings":["Sponsor: Dr. Arthur Weltman, FACSM)","University of Virginia, Charlottesville, VA","(No relationships reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sponsor: Dr. Arthur Weltman, FACSM)","institution_ids":[]},{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"(No relationships reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.19181112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"41","issue":"5","first_page":"65","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.24959999322891235,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cardiorespiratory-fitness","display_name":"cardiorespiratory fitness","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vo2max","display_name":"VO2max","score":0.9639999866485596},{"id":"https://openalex.org/keywords/postprandial-state","display_name":"postprandial state","score":0.699999988079071},{"id":"https://openalex.org/keywords/high-fat-meal","display_name":"high-fat meal","score":0.9380000233650208},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9610000252723694},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/brachial-artery","display_name":"brachial artery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/coronary-artery-disease-risk","display_name":"coronary artery disease risk","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sedentary-women","display_name":"sedentary women","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.84919273853302},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.812656044960022},{"id":"https://openalex.org/C3019128504","wikidata":"https://www.wikidata.org/wiki/Q948806","display_name":"Reactive hyperemia","level":3,"score":0.7532047033309937},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.7287024259567261},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.7195495367050171},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6051864624023438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5895818471908569},{"id":"https://openalex.org/C2780214079","wikidata":"https://www.wikidata.org/wiki/Q228537","display_name":"Forearm","level":2,"score":0.4845503866672516},{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.47578394412994385},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4749969244003296},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.4692038893699646},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.45563948154449463},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.3184986114501953},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24329322576522827},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1722792685031891}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000354760.94691.16","doi":"https://doi.org/10.1249/01.mss.0000354760.94691.16","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000354760.94691.16","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine & Science in Sports & Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045110956","https://openalex.org/W1990516860","https://openalex.org/W2805782374","https://openalex.org/W4281626652","https://openalex.org/W4389021839","https://openalex.org/W2010892018","https://openalex.org/W2057773882","https://openalex.org/W4251878065","https://openalex.org/W215184582","https://openalex.org/W2119173363"],"abstract_inverted_index":{"Endothelial":[0],"dysfunction":[1,38,60],"is":[2,44,238],"a":[3,23,30,66,127,151,191,247],"known":[4],"predictor":[5],"of":[6,22,36,65,150,175,187,202],"coronary":[7],"artery":[8,113,133,178,204],"disease":[9],"(CAD)":[10],"and":[11,39,111,125,144,146,160,181,222,229],"may":[12,266],"be":[13,267],"worsened":[14],"in":[15,70,243,261],"the":[16,34,63,101,176,262],"postprandial":[17,58,263],"state,":[18],"particularly":[19],"after":[20,148],"ingestion":[21,64,149],"high-fat":[24,67,152],"meal.":[25],"Post-menopausal":[26],"status":[27],"also":[28],"confers":[29],"greater":[31],"risk":[32],"for":[33,109],"development":[35],"endothelial":[37,48,59,259],"CAD,":[40],"whereas":[41],"cardiorespiratory":[42],"fitness":[43,55,254,275],"positively":[45],"associated":[46,239,255],"with":[47,190,240,252,256],"function.":[49],"PURPOSE:":[50],"To":[51],"examine":[52],"if":[53],"increased":[54,241,273],"(VO2max)":[56],"attenuates":[57],"that":[61],"follows":[62],"meal":[68,154,250],"challenge":[69,155],"sedentary":[71,76],"post-menopausal":[72,77,244],"women.":[73],"METHODS:":[74],"Fifteen":[75],"women":[78,245],"(Age=56.6":[79],"+":[80,84,90,93],"4.2":[81],"yr;":[82],"BMI=27.0":[83],"4.9":[85],"kg/m2;":[86],"%":[87],"body":[88],"fat=40.9":[89],"7.1%;":[91],"VO2max=22.6":[92],"4.3":[94],"ml.kg-1.min-1;":[95],"range":[96],"=16.4-31.5)":[97],"were":[98,206],"admitted":[99],"to":[100],"General":[102],"Clinical":[103],"Research":[104],"Center":[105],"on":[106,126],"two":[107],"occasions":[108],"VO2max":[110,221],"brachial":[112,132,177,203],"flow":[114,134],"mediated":[115,135],"dilation":[116,136,165],"testing.":[117],"Subjects":[118],"underwent":[119,130],"an":[120,141,257],"incremental":[121],"VO2":[122],"max":[123],"protocol":[124],"separate":[128],"day":[129],"serial":[131],"measurements":[137],"at":[138,179,195,224],"baseline":[139],"(after":[140],"overnight":[142],"fast)":[143],"2":[145,225],"4-hours":[147],"breakfast":[153],"(57%":[156],"fat,":[157],"25%":[158],"protein,":[159],"18%":[161],"carbohydrate).":[162],"Percent":[163],"flow-mediated":[164],"(%":[166],"FMD)":[167],"was":[168,218],"quantified":[169],"by":[170,208,271],"comparing":[171],"B-mode":[172],"ultrasound":[173],"images":[174],"rest":[180],"during":[182],"reactive":[183],"hyperemia":[184],"following":[185,246],"5-min":[186],"forearm":[188],"occlusion":[189],"blood":[192,199],"pressure":[193],"cuff":[194],"50mmHg":[196],"above":[197],"systolic":[198],"pressure.":[200],"Measurements":[201],"diameter":[205],"made":[207],"using":[209],"computerized":[210],"edge":[211],"detection":[212],"software.":[213],"RESULTS:":[214],"A":[215],"significant":[216],"relationship":[217],"observed":[219],"between":[220],"%FMD":[223,242],"hours":[226,231],"(r=.52,":[227],"p=0.047)":[228],"4":[230],"(r=0.63,":[232],"p=":[233],"0.012)":[234],"postprandially.":[235],"CONCLUSION:":[236],"Fitness":[237],"high":[248],"fat":[249],"challenge,":[251],"elevated":[253],"improved":[258],"response":[260],"period.":[264],"This":[265],"yet":[268],"another":[269],"mechanism":[270],"which":[272],"cardio-respiratory":[274],"lowers":[276],"cardiovascular":[277],"risk.":[278]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}