{"id":"https://openalex.org/W2070437985","doi":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","title":"The Family of Retinoblastoma Proteins","display_name":"The Family of Retinoblastoma Proteins","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2070437985","doi":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","mag":"2070437985","pmid":"https://pubmed.ncbi.nlm.nih.gov/11693966"},"language":"en","primary_location":{"id":"doi:10.1615/critreveukargeneexpr.v11.i1-3.40","doi":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","pdf_url":null,"source":{"id":"https://openalex.org/S7783507","display_name":"Critical Reviews in Eukaryotic Gene Expression","issn_l":"1045-4403","issn":["1045-4403","2162-6502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u0099 in Eukaryotic Gene Expression","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017589179","display_name":"Peter Stiegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Stiegler","raw_affiliation_strings":["Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107","Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024798356","display_name":"Antonio Giordano","orcid":"https://orcid.org/0000-0002-5959-016X","observed_orcids":["https://orcid.org/0000-0002-5959-016X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Giordano","raw_affiliation_strings":["Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2219,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79173604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"1-3","first_page":"18","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prb2-p130","display_name":"pRb2/p130","score":0.996999979019165},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cell-growth-regulation","display_name":"cell growth regulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-interaction-partners","display_name":"protein binding partners","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.875431478023529},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.6836940050125122},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5549564361572266},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.47060757875442505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4699343144893646},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4582386016845703},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43787866830825806},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4357704520225525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4079650640487671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40143364667892456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35993826389312744},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.17411702871322632},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1396676003932953},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11179831624031067}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019942","descriptor_name":"Genes, p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050717","descriptor_name":"Retinoblastoma-Like Protein p130","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050720","descriptor_name":"Retinoblastoma-Like Protein p107","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050756","descriptor_name":"Cyclin-Dependent Kinase Inhibitor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1615/critreveukargeneexpr.v11.i1-3.40","doi":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.40","pdf_url":null,"source":{"id":"https://openalex.org/S7783507","display_name":"Critical Reviews in Eukaryotic Gene Expression","issn_l":"1045-4403","issn":["1045-4403","2162-6502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u0099 in Eukaryotic Gene Expression","raw_type":"journal-article"},{"id":"pmid:11693966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11693966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in eukaryotic gene expression","raw_type":"Journal Article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/1129250","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/1129250","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087390195","https://openalex.org/W2473459363","https://openalex.org/W1531681328","https://openalex.org/W2402792745","https://openalex.org/W2086948825","https://openalex.org/W4239473720","https://openalex.org/W2434085508","https://openalex.org/W2026106245","https://openalex.org/W7096222399","https://openalex.org/W2095357692"],"abstract_inverted_index":{"Our":[0],"understanding":[1],"of":[2,28,96,118,123],"how":[3,23,58],"the":[4,41,59,81,108,119,124],"retinoblastoma":[5,42,126],"family":[6,127],"members,":[7],"pRB/p105,":[8],"pRB2/p130,":[9],"and":[10,51,66,90,121,129],"pRBL1/p107,":[11,91],"regulate":[12,37],"cellular":[13,49,83,134],"properties":[14,27,76,120],"has":[15,55,104],"progressed":[16],"significantly.":[17],"Mechanisms":[18],"have":[19,44],"been":[20,45,105],"described":[21,72],"regarding":[22],"these":[24],"proteins":[25,43],"utilize":[26],"additional":[29],"factors,":[30],"such":[31],"as":[32,77,79,99,101],"histone":[33],"deacetylases,":[34],"to":[35,63],"negatively":[36],"transcription.":[38],"More":[39],"importantly,":[40],"integrated":[46],"within":[47],"multiple":[48],"pathways,":[50],"a":[52],"complex":[53],"view":[54],"emerged":[56],"on":[57],"individual":[60,98],"members":[61,128],"respond":[62],"various":[64],"external":[65],"internal":[67],"stimuli.":[68],"pRB/p105":[69],"is":[70,86],"best":[71],"in":[73,80,133],"its":[74],"biochemical":[75],"well":[78,100],"resulting":[82],"functions.":[84],"Less":[85],"known":[87],"about":[88],"pRB2/p130":[89],"but":[92],"an":[93],"improved":[94],"map":[95],"their":[97,130],"redundant":[102],"functions":[103,122],"drawn":[106],"over":[107],"last":[109],"years.":[110],"In":[111],"this":[112],"review":[113],"we":[114],"describe":[115],"general":[116],"aspects":[117],"three":[125],"protein-binding":[131],"partners":[132],"growth":[135],"control.":[136]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}