{"id":"https://openalex.org/W2070410596","doi":"https://doi.org/10.1038/jcbfm.1994.56","title":"SPECT Quantification of [ 123 I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: II. Equilibrium Analysis of Constant Infusion Experiments and Correlation with in vitro Parameters","display_name":"SPECT Quantification of [ 123 I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: II. Equilibrium Analysis of Constant Infusion Experiments and Correlation with in vitro Parameters","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W2070410596","doi":"https://doi.org/10.1038/jcbfm.1994.56","mag":"2070410596","pmid":"https://pubmed.ncbi.nlm.nih.gov/8163587"},"language":"en","primary_location":{"id":"doi:10.1038/jcbfm.1994.56","doi":"https://doi.org/10.1038/jcbfm.1994.56","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.56","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.56","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.56","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087635866","display_name":"Marc A. Laruelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Laruelle","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072395467","display_name":"Anissa Abi\u2010Dargham","orcid":"https://orcid.org/0000-0002-5039-5069","observed_orcids":["https://orcid.org/0000-0002-5039-5069"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anissa Abi-Dargham","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098118104","display_name":"Mohammed S. AI-Tikriti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed S. AI-Tikriti","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112761609","display_name":"Ronald M. Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Baldwin","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084979953","display_name":"Yolanda Zea\u2010Ponce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolanda Zea-Ponce","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039918144","display_name":"Sami S. Zoghbi","orcid":"https://orcid.org/0000-0001-5613-8314","observed_orcids":["https://orcid.org/0000-0001-5613-8314","https://orcid.org/0009-0001-4145-7029"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami S. Zoghbi","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012699156","display_name":"Dennis S. Charney","orcid":"https://orcid.org/0000-0003-0610-3433","observed_orcids":["https://orcid.org/0000-0003-0610-3433"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis S. Charney","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109067382","display_name":"Paul B. Hoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul B. Hoffer","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079125204","display_name":"Robert B. Innis","orcid":"https://orcid.org/0000-0003-1238-7209","observed_orcids":["https://orcid.org/0000-0003-1238-7209"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Innis","raw_affiliation_strings":["Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut and West Haven VA Medical Center, West Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.5827,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.9125595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"453","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/123i-iomazenil","display_name":"123I-iomazenil","score":0.9909999966621399},{"id":"https://openalex.org/keywords/receptor-binding-quantification","display_name":"receptor binding quantification","score":0.656000018119812},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.8650000095367432},{"id":"https://openalex.org/keywords/binding-site-density","display_name":"binding site density","score":0.6060000061988831},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.4269999861717224},{"id":"https://openalex.org/keywords/scatchard-analysis","display_name":"Scatchard analysis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/flumazenil","display_name":"flumazenil","score":0.699999988079071},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.5680000185966492},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.5509999990463257},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7260000109672546},{"id":"https://openalex.org/keywords/occipital-cortex","display_name":"occipital cortex","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.7581155896186829},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.7042888402938843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6664032936096191},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.611511766910553},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.5927883982658386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5406986474990845},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.5144989490509033},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.475352019071579},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4279370903968811},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3223370313644409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13175469636917114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1310446560382843},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13036885857582092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11913344264030457},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/jcbfm.1994.56","doi":"https://doi.org/10.1038/jcbfm.1994.56","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.56","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.56","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},{"id":"pmid:8163587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8163587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1038/jcbfm.1994.56","doi":"https://doi.org/10.1038/jcbfm.1994.56","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.56","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.56","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1686341833","display_name":null,"funder_award_id":"NS-06208","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6876395304","display_name":null,"funder_award_id":"MHS25642","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8021097720","display_name":"YALE EPILEPSY RESEARCH CENTER","funder_award_id":"P50NS006208","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2070410596.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1489935189","https://openalex.org/W1502161641","https://openalex.org/W1912649373","https://openalex.org/W1978735196","https://openalex.org/W1983649348","https://openalex.org/W1985050254","https://openalex.org/W1989035076","https://openalex.org/W1998719238","https://openalex.org/W2003090874","https://openalex.org/W2007510516","https://openalex.org/W2008745330","https://openalex.org/W2015107494","https://openalex.org/W2015996876","https://openalex.org/W2017273367","https://openalex.org/W2031903860","https://openalex.org/W2043813981","https://openalex.org/W2046045427","https://openalex.org/W2049819189","https://openalex.org/W2066735646","https://openalex.org/W2071236177","https://openalex.org/W2080894693","https://openalex.org/W2096998012","https://openalex.org/W2121887890","https://openalex.org/W2126859077","https://openalex.org/W2141921310"],"related_works":["https://openalex.org/W2017273367","https://openalex.org/W2141921310","https://openalex.org/W2184076903","https://openalex.org/W7100217003","https://openalex.org/W2065021005","https://openalex.org/W2298783031","https://openalex.org/W1989844973","https://openalex.org/W2029173430","https://openalex.org/W2041110074","https://openalex.org/W2126489248"],"abstract_inverted_index":{"In":[0,154],"vivo":[1,178],"benzodiazepine":[2,43],"receptor":[3,81],"equilibrium":[4,51],"dissociation":[5],"constant,":[6],"KD,":[7],"and":[8,49,56,60,104,118,137,140,146,163,196],"maximum":[9],"number":[10],"of":[11,39,68,77,84,101,111,157],"binding":[12],"sites,":[13],"Bmax,":[14],"were":[15,28,52,61,95,135,142,172],"measured":[16,143,180],"by":[17,34,181],"single":[18],"photon":[19],"emission":[20],"computerized":[21],"tomography":[22],"(SPECT)":[23],"in":[24,123,130,173,177],"three":[25],"baboons.":[26],"Animals":[27],"injected":[29,89],"with":[30,176],"a":[31,35,80],"bolus":[32],"followed":[33],"constant":[36],"i.v.":[37],"infusion":[38],"the":[40,64,69,75,78,112,124,131],"high":[41],"affinity":[42],"ligand":[44],"[123I]iomazenil.":[45],"Plasma":[46],"steady-state":[47],"concentration":[48],"receptor-ligand":[50],"reached":[53],"within":[54],"2":[55],"3":[57],"h,":[58],"respectively,":[59],"sustained":[62],"for":[63,109],"duration":[65],"(4-9":[66],"h)":[67],"experiments":[70],"(n":[71],"=":[72],"15).":[73],"At":[74],"end":[76],"experiments,":[79],"saturating":[82],"dose":[83],"flumazenil":[85],"(0.2":[86],"mg/kg)":[87],"was":[88,107],"to":[90,127,191],"measure":[91],"nondisplaceable":[92],"activity.":[93],"Experiments":[94],"carried":[96],"out":[97],"at":[98,144],"various":[99],"levels":[100],"specific":[102],"activity,":[103],"Scatchard":[105],"analysis":[106],"performed":[108],"derivation":[110],"KD":[113,141,167],"(0.59":[114],"+/-":[115,160,169],"0.09":[116],"nM)":[117,162,171],"Bmax":[119,139,158],"(from":[120],"126":[121],"nM":[122,129],"occipital":[125,151],"region":[126],"68":[128],"striatum).":[132],"Two":[133],"animals":[134],"killed":[136],"[125I]iomazenil":[138],"22":[145],"37":[147,164],"degrees":[148,165],"C":[149,166],"on":[150],"homogenate":[152],"membranes.":[153],"vitro":[155],"values":[156,179],"(114":[159],"33":[161],"(0.66":[168],"0.16":[170],"good":[174],"agreement":[175],"SPECT.":[182],"This":[183],"study":[184],"demonstrates":[185],"that":[186],"SPECT":[187],"can":[188],"be":[189],"used":[190],"quantify":[192],"central":[193],"neuroreceptors":[194],"density":[195],"affinity.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}