{"id":"https://openalex.org/W2070375238","doi":"https://doi.org/10.1074/jbc.m113.468298","title":"Campylobacter jejuni Lipooligosaccharide Sialylation, Phosphorylation, and Amide/Ester Linkage Modifications Fine-tune Human Toll-like Receptor 4 Activation","display_name":"Campylobacter jejuni Lipooligosaccharide Sialylation, Phosphorylation, and Amide/Ester Linkage Modifications Fine-tune Human Toll-like Receptor 4 Activation","publication_year":2013,"publication_date":"2013-04-30","ids":{"openalex":"https://openalex.org/W2070375238","doi":"https://doi.org/10.1074/jbc.m113.468298","mag":"2070375238","pmid":"https://pubmed.ncbi.nlm.nih.gov/23629657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3707672"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.468298","doi":"https://doi.org/10.1074/jbc.m113.468298","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.468298","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820456832/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021925820456832/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046020899","display_name":"Holly N. Stephenson","orcid":"https://orcid.org/0000-0002-8121-9252","observed_orcids":["https://orcid.org/0000-0002-8121-9252"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Holly N. Stephenson","raw_affiliation_strings":["Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom","From the Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"From the Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom,","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035234881","display_name":"Constance M. John","orcid":"https://orcid.org/0000-0003-4984-6325","observed_orcids":["https://orcid.org/0000-0003-4984-6325"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constance M. John","raw_affiliation_strings":["Department of Laboratory Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, and","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078486352","display_name":"Neveda Naz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neveda Naz","raw_affiliation_strings":["Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052990907","display_name":"Ozan Gundogdu","orcid":"https://orcid.org/0000-0002-3550-0545","observed_orcids":["https://orcid.org/0000-0002-3550-0545"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ozan Gundogdu","raw_affiliation_strings":["Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006037710","display_name":"Nick Dorrell","orcid":"https://orcid.org/0000-0003-1144-6502","observed_orcids":["https://orcid.org/0000-0003-1144-6502"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Dorrell","raw_affiliation_strings":["Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023116254","display_name":"Brendan William Wren","orcid":"https://orcid.org/0000-0002-6140-9489","observed_orcids":["https://orcid.org/0000-0002-6140-9489"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brendan W. Wren","raw_affiliation_strings":["Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015010568","display_name":"Gary A. Jarvis","orcid":"https://orcid.org/0000-0002-7576-3702","observed_orcids":["https://orcid.org/0000-0002-7576-3702"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary A. Jarvis","raw_affiliation_strings":["Department of Laboratory Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, and","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019987721","display_name":"Mona Bajaj\u2010Elliott","orcid":"https://orcid.org/0000-0002-5234-576X","observed_orcids":["https://orcid.org/0000-0002-5234-576X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mona Bajaj-Elliott","raw_affiliation_strings":["From the Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom,","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015010568"],"corresponding_institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.6504,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89794052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"288","issue":"27","first_page":"19661","last_page":"19672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/campylobacter-jejuni","display_name":"Campylobacter jejuni","score":1.0},{"id":"https://openalex.org/keywords/lipooligosaccharide","display_name":"lipooligosaccharide","score":1.0},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sialylation","display_name":"sialylation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/gastroenteritis","display_name":"gastroenteritis","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2776957140","wikidata":"https://www.wikidata.org/wiki/Q265488","display_name":"Campylobacter jejuni","level":3,"score":0.9225056171417236},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5857549905776978},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5433566570281982},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5421626567840576},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5337921380996704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4653639793395996},{"id":"https://openalex.org/C2779910956","wikidata":"https://www.wikidata.org/wiki/Q131488","display_name":"Campylobacter","level":3,"score":0.4460427165031433},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4417967200279236},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.43100807070732117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4264032244682312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38991740345954895},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.30167800188064575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2760416865348816},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22289764881134033},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1695394515991211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09961682558059692}],"mesh":[{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m113.468298","doi":"https://doi.org/10.1074/jbc.m113.468298","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.468298","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820456832/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3057195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3707672","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3707672","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3707672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23629657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23629657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1393121","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1393121/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF BIOLOGICAL CHEMISTRY , 288 (27) pp. 19661-19672. (2013)","raw_type":"Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:1472227","doi":null,"is_oa":false,"landing_page_url":"http://researchonline.lshtm.ac.uk/1472227/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference or Workshop Item"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.468298","doi":"https://doi.org/10.1074/jbc.m113.468298","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.468298","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820456832/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3348954569","display_name":"Structural Characterization of Polypeptides, Protein Complexes, Oligosaccharides","funder_award_id":"S10RR029446","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4909373701","display_name":null,"funder_award_id":"BB/C519670/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5334010142","display_name":"Bio-Organic Biomedical Mass Spectrometry Resource","funder_award_id":"P41RR001614","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7953786186","display_name":null,"funder_award_id":"EGA16167","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8780596351","display_name":null,"funder_award_id":"I01 BX000727","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000868711","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA082103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306202","display_name":"Gordon and Betty Moore Foundation","ror":"https://ror.org/006wxqw41"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070375238.pdf","grobid_xml":"https://content.openalex.org/works/W2070375238.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1538572377","https://openalex.org/W1576934911","https://openalex.org/W1976891658","https://openalex.org/W1979086877","https://openalex.org/W1981558302","https://openalex.org/W1985199672","https://openalex.org/W1992066825","https://openalex.org/W1998453083","https://openalex.org/W1999254509","https://openalex.org/W2012662786","https://openalex.org/W2028417315","https://openalex.org/W2039347160","https://openalex.org/W2052800627","https://openalex.org/W2054198559","https://openalex.org/W2065134483","https://openalex.org/W2087041328","https://openalex.org/W2095619327","https://openalex.org/W2098157455","https://openalex.org/W2100334884","https://openalex.org/W2101378591","https://openalex.org/W2102484955","https://openalex.org/W2109975723","https://openalex.org/W2110076909","https://openalex.org/W2110468713","https://openalex.org/W2112879979","https://openalex.org/W2117239946","https://openalex.org/W2123958685","https://openalex.org/W2127172172","https://openalex.org/W2127934565","https://openalex.org/W2128897591","https://openalex.org/W2129319296","https://openalex.org/W2134080655","https://openalex.org/W2137966873","https://openalex.org/W2139833332","https://openalex.org/W2142143757","https://openalex.org/W2142992860","https://openalex.org/W2143236729","https://openalex.org/W2146167147","https://openalex.org/W2160993282","https://openalex.org/W2164237791","https://openalex.org/W2171976568","https://openalex.org/W2172179018","https://openalex.org/W4240236037"],"related_works":["https://openalex.org/W606346934","https://openalex.org/W2172090534","https://openalex.org/W3045168850","https://openalex.org/W3013402167","https://openalex.org/W2790498644","https://openalex.org/W2883153492","https://openalex.org/W2097654459","https://openalex.org/W2085236191","https://openalex.org/W7098174482","https://openalex.org/W2512871318"],"abstract_inverted_index":{"Campylobacter":[0,206],"jejuni":[1,10,58,91,196,207,247,260],"is":[2,13,210,249],"a":[3,14,211],"leading":[4],"cause":[5],"of":[6,17,26,47,118,125,161,194,214,222,238,255],"acute":[7],"gastroenteritis.":[8],"C.":[9,57,90,195,246,259],"lipooligosaccharide":[11,208],"(LOS)":[12,209],"potent":[15],"activator":[16],"Toll-like":[18],"receptor":[19],"(TLR)":[20],"4-mediated":[21],"innate":[22,216],"immunity.":[23,168,217],"Structural":[24],"variations":[25,189],"the":[27,34,38,45,48,83,116,158,162,223],"LOS":[28,53,104,163,197,224,239,256],"have":[29],"been":[30],"previously":[31],"reported":[32],"in":[33,81,95,107,140,165,190,231],"oligosaccharide":[35],"(OS)":[36],"moiety,":[37],"disaccharide":[39],"lipid":[40],"A":[41],"(LA)":[42],"backbone,":[43],"and":[44,65,85,98,130,143,201,230,253],"phosphorylation":[46,131],"LA.":[49],"Here,":[50],"we":[51],"studied":[52],"structural":[54,79,105,111,192,220],"variation":[55,80,106,112,254],"between":[56,228],"strains":[59,180,229,261],"associated":[60],"with":[61,103,115,135,179,182],"different":[62,89],"ecological":[63],"sources":[64],"analyzed":[66],"their":[67],"ability":[68],"to":[69,77,151],"activate":[70],"TLR4":[71,136,199],"function.":[72],"MALDI-TOF":[73],"MS":[74],"was":[75,101,113],"performed":[76],"characterize":[78],"both":[82],"OS":[84,121,169],"LA":[86,126,174],"among":[87,258],"15":[88],"isolates.":[92],"Cytokine":[93],"induction":[94],"THP-1":[96,141],"cells":[97,142],"primary":[99],"monocytes":[100],"correlated":[102,114,134],"each":[108,119],"strain.":[109,120],"Additionally,":[110],"source":[117],"sialylation,":[122],"increasing":[123],"abundance":[124],"d-glucosamine":[127],"versus":[128],"2,3-diamino-2,3-dideoxy-d-glucose,":[129],"status":[132,171],"all":[133],"activation":[137,200],"as":[138],"measured":[139],"monocytes.":[144],"Importantly,":[145],"LOS-induced":[146],"inflammatory":[147],"responses":[148],"were":[149],"similar":[150],"those":[152],"elicited":[153],"by":[154],"live":[155],"bacteria,":[156],"highlighting":[157],"prominent":[159],"contribution":[160],"component":[164],"driving":[166],"host":[167,215,264],"sialylation":[170],"but":[172],"not":[173],"structure":[175,240,257],"showed":[176],"significant":[177],"association":[178],"clustering":[181],"livestock":[183],"sources.":[184],"Our":[185],"study":[186],"highlights":[187],"how":[188],"three":[191],"components":[193],"alter":[198],"consequent":[202],"monocyte":[203,234],"activation.":[204,235],"Background:":[205],"critical":[212],"determinant":[213],"Results:":[218],"Three":[219],"features":[221],"moiety":[225],"vary":[226],"significantly":[227],"combination":[232],"impact":[233,263],"Conclusion:":[236],"Variation":[237],"suggests":[241],"that":[242],"LOS-TLR4":[243],"engagement":[244],"during":[245],"infection":[248],"strain-specific.":[250],"Significance:":[251],"Source":[252],"may":[262],"proinflammatory":[265],"responses.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
