{"id":"https://openalex.org/W2070339573","doi":"https://doi.org/10.1073/pnas.75.9.4422","title":"Depression of cytidine 3':5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs.","display_name":"Depression of cytidine 3':5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W2070339573","doi":"https://doi.org/10.1073/pnas.75.9.4422","mag":"2070339573","pmid":"https://pubmed.ncbi.nlm.nih.gov/212750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/336127"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.75.9.4422","doi":"https://doi.org/10.1073/pnas.75.9.4422","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.75.9.4422","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC336127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039994535","display_name":"David M. Helfman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Helfman","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086926357","display_name":"Nancy L. Brackett","orcid":"https://orcid.org/0000-0002-4197-2784","observed_orcids":["https://orcid.org/0000-0002-4197-2784"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N L Brackett","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108902860","display_name":"J.F. Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Kuo","raw_affiliation_strings":["Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":1.4521,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80218013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"75","issue":"9","first_page":"4422","last_page":"4425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-amp-phosphodiesterase","display_name":"cyclic AMP phosphodiesterase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cyclic-gmp-phosphodiesterase","display_name":"cyclic GMP phosphodiesterase","score":1.0},{"id":"https://openalex.org/keywords/cyclic-nucleotide-metabolism","display_name":"cyclic nucleotide metabolism","score":0.6549999713897705},{"id":"https://openalex.org/keywords/ontogeny","display_name":"ontogeny","score":0.7200000286102295},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6940000057220459},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.5049999952316284},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9079999923706055},{"id":"https://openalex.org/keywords/intestine","display_name":"intestine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9860000014305115},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.8052457571029663},{"id":"https://openalex.org/C2781184954","wikidata":"https://www.wikidata.org/wiki/Q422538","display_name":"Cytidine","level":3,"score":0.733465313911438},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5940476655960083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5739370584487915},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5396345853805542},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.49613484740257263},{"id":"https://openalex.org/C3020139451","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic gmp","level":3,"score":0.48129597306251526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46827033162117004},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4546736180782318},{"id":"https://openalex.org/C2780215583","wikidata":"https://www.wikidata.org/wiki/Q946700","display_name":"Cyclic nucleotide phosphodiesterase","level":4,"score":0.44931310415267944},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.41389399766921997},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4131767749786377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3773896396160126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34766557812690735},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2655978202819824},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.19356417655944824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10337311029434204},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09582191705703735},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.07826423645019531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003568","descriptor_name":"Cytidine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009712","descriptor_name":"Nucleotides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.75.9.4422","doi":"https://doi.org/10.1073/pnas.75.9.4422","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.75.9.4422","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:57143","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC336127","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:336127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/336127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:212750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/212750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:57143","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC336127","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W168583190","https://openalex.org/W1490938706","https://openalex.org/W1542630845","https://openalex.org/W1588285827","https://openalex.org/W1981135378","https://openalex.org/W1994470575","https://openalex.org/W2029525488","https://openalex.org/W2034164618","https://openalex.org/W2075513286","https://openalex.org/W2461788277","https://openalex.org/W4211171739","https://openalex.org/W4301381893"],"related_works":["https://openalex.org/W1971185675","https://openalex.org/W1542630845","https://openalex.org/W290095527","https://openalex.org/W2057710771","https://openalex.org/W2070486221","https://openalex.org/W2065638600","https://openalex.org/W2026922380","https://openalex.org/W1981135378","https://openalex.org/W2035499918","https://openalex.org/W1996812489"],"abstract_inverted_index":{"Changes":[0],"in":[1,13,50,69,79,92,102,139],"levels":[2,60,90,103],"of":[3,25,43,61,72,98,104,152,166],"the":[4,51,58,67,73,77,80,84,99,122,129,164],"newly":[5],"discovered":[6],"cytidine":[7],"3':5'-cyclic":[8],"monophosphate":[9],"(cyclic":[10],"CMP)":[11],"phosphodiesterase":[12,64,110,126],"some":[14,93],"representative":[15],"tissues":[16,75,82,141],"(cerebral":[17],"cortex,":[18],"kidney,":[19],"intestine,":[20],"liver,":[21],"heart,":[22],"and":[23,35,39,46,86,107,115],"lung)":[24],"guinea":[26],"pigs":[27],"from":[28,83],"various":[29],"developmental":[30],"stages":[31],"(fetus,":[32],"neonate,":[33],"pup,":[34],"adult)":[36],"were":[37,65,113],"studied":[38],"compared":[40],"with":[41,88],"those":[42],"cyclic":[44,47,62,105,108,124,131,153,167,170],"AMP":[45,106,168],"GMP":[48,109],"phosphodiesterases":[49],"same":[52],"tissues.":[53,95],"It":[54],"was":[55],"observed":[56],"that":[57,121,150],"tissue":[59,116],"CMP":[63,125,132,154],"invariably":[66],"lowest":[68],"every":[70],"one":[71],"fetal":[74],"examined,":[76],"highest":[78],"corresponding":[81],"pups":[85],"adult,":[87],"intermediate":[89],"seen":[91],"neonatal":[94],"The":[96,146],"patterns":[97],"ontogenetic":[100],"changes":[101],"activities,":[111],"however,":[112],"variable":[114],"specific.":[117],"These":[118],"findings":[119],"suggest":[120,149],"depressed":[123],"activity":[127],"(hence,":[128],"elevated":[130],"concentration)":[133],"is":[134,155],"perhaps":[135,156],"a":[136],"common":[137],"factor":[138],"developing":[140],"undergoing":[142],"rapid":[143],"cell":[144,161],"proliferation.":[145],"data":[147],"also":[148],"metabolism":[151,165],"more":[157],"closely":[158],"related":[159],"to":[160],"proliferation":[162],"than":[163],"or":[169],"GMP.":[171]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}