{"id":"https://openalex.org/W2070329072","doi":"https://doi.org/10.1097/00007890-199305000-00015","title":"THE BENEFICIAL EFFECTS OF STEROID WITHDRAWAL ON BLOOD PRESSURE AND LIPID PROFILE IN CHILDREN POSTTRANSPLANTATION IN THE CYCLOSPORINE ERA","display_name":"THE BENEFICIAL EFFECTS OF STEROID WITHDRAWAL ON BLOOD PRESSURE AND LIPID PROFILE IN CHILDREN POSTTRANSPLANTATION IN THE CYCLOSPORINE ERA","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W2070329072","doi":"https://doi.org/10.1097/00007890-199305000-00015","mag":"2070329072","pmid":"https://pubmed.ncbi.nlm.nih.gov/8497876"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199305000-00015","doi":"https://doi.org/10.1097/00007890-199305000-00015","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199305000-00015","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039281014","display_name":"Elizabeth G. Ingulli","orcid":"https://orcid.org/0000-0003-2591-8945","observed_orcids":["https://orcid.org/0000-0003-2591-8945"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELIZABETH INGULLI","raw_affiliation_strings":["Department of Pediatrics, SUNY Health Science Center, Brooklyn 11203","Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, SUNY Health Science Center, Brooklyn 11203","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037453705","display_name":"Amir H. Tejani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AMIR TEJANI","raw_affiliation_strings":["Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111807461","display_name":"M. Markell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARIANA MARKELL","raw_affiliation_strings":["Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division of the Department of Pediatrics and the Department of Medicine, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8363,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95639944,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"55","issue":"5","first_page":"1029","last_page":"1033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroid-withdrawal","display_name":"corticosteroid withdrawal","score":0.9570000171661377},{"id":"https://openalex.org/keywords/prednisone-taper","display_name":"prednisone taper","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.902999997138977},{"id":"https://openalex.org/keywords/pediatric-kidney-transplantation","display_name":"pediatric kidney transplantation","score":0.777999997138977},{"id":"https://openalex.org/keywords/post-transplant-hypertension","display_name":"post-transplant hypertension","score":0.746999979019165},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6890000104904175},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7630000114440918},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.5559999942779541},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.6700000166893005},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.5009999871253967},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5429999828338623},{"id":"https://openalex.org/keywords/pediatric-chronic-kidney-disease","display_name":"pediatric chronic kidney disease","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.764391303062439},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7111998200416565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7025631070137024},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6558203101158142},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4887978732585907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43823176622390747},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4051956534385681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4043480455875397},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3874422311782837},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3247833251953125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3072993755340576},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.18880945444107056}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199305000-00015","doi":"https://doi.org/10.1097/00007890-199305000-00015","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199305000-00015","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:8497876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8497876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979566486","https://openalex.org/W2006892141","https://openalex.org/W2018609116","https://openalex.org/W2002870312","https://openalex.org/W2120095600","https://openalex.org/W2017278250","https://openalex.org/W2086783665","https://openalex.org/W2399459610","https://openalex.org/W2104707022","https://openalex.org/W2467043041"],"abstract_inverted_index":{"Steroid":[0],"therapy":[1,388],"posttransplantation":[2],"has":[3],"been":[4],"correlated":[5],"with":[6,82,178,336],"hyperlipidemia":[7,20],"and":[8,21,61,86,101,111,127,221,271,333,355,381],"hypertension.":[9],"With":[10],"improved":[11],"graft":[12,84],"survivals":[13],"in":[14,45,65,76,161,308,322,369],"the":[15,39,52,137,165,210,345,370],"cyclosporine":[16],"(CsA)":[17],"era,":[18],"post-tx":[19,67,389],"hypertension":[22],"may":[23,390],"place":[24],"children":[25,66,384],"at":[26,235,250,265,274,287,329,392],"high":[27],"risk":[28,394],"for":[29,182,395],"early":[30],"atherosclerosis.":[31],"Presently":[32],"there":[33],"are":[34,107,173],"no":[35,102],"large":[36],"studies":[37],"assessing":[38],"metabolic":[40],"effects":[41],"of":[42,54,139,164,186,209,229,378],"steroid":[43,231],"withdrawal":[44,56,125],"tx":[46,151],"children.":[47],"Thus,":[48],"we":[49],"report":[50],"on":[51,57,69,78,198,339,372,375,385],"effect":[53],"prednisone":[55],"blood":[58],"pressure,":[59],"weight,":[60,110],"serum":[62,114],"lipid":[63],"levels":[64,117],"maintained":[68,175],"CsA":[70,79],"alone.":[71],"Pred":[72,157],"taper":[73],"is":[74,87,96,99],"attempted":[75],"patients":[77,135,193,211,324,338],"(6-7":[80],"mg/kg/day)":[81],"stable":[83,179],"function":[85,181],"extended":[88],"over":[89],"a":[90,94,183],"6-month":[91],"period.":[92],"Once":[93],"rejection":[95,202,218],"diagnosed":[97],"pred":[98,132,177,199,326,340,387],"restarted":[100,197],"future":[103],"attempts":[104],"to":[105,123,195,201,216,225],"withdraw":[106],"made.":[108],"BP,":[109],"overnight":[112],"fasting":[113],"cholesterol":[115],"(Schol)":[116],"were":[118,143,280,364],"measured":[119,321],"1":[120],"month":[121],"prior":[122],"complete":[124],"(A),":[126],"after":[128,206],"6":[129,145],"months":[130,146,188,205],"without":[131],"(B).":[133],"In":[134],"requiring":[136],"restart":[138],"pred,":[140],"subsequent":[141],"measurements":[142],"obtained":[144],"later":[147],"(C).":[148],"Of":[149,168],"74":[150],"children,":[152],"7":[153],"had":[154,194],"primary":[155],"nonfunction.":[156],"was":[158,244,310,320,334],"successfully":[159],"withdrawn":[160],"49%":[162],"(33)":[163],"remaining":[166],"67.":[167],"these":[169],"patients,":[170],"42%":[171],"(14/33)":[172],"still":[174],"off":[176,325],"renal":[180],"mean":[184],"duration":[185],"58.5":[187],"(range":[189],"8-99":[190],"months).":[191],"Nineteen":[192],"be":[196,391],"secondary":[200],"between":[203],"7-36":[204],"withdrawal.":[207,232],"Three":[208],"subsequently":[212],"lost":[213],"their":[214],"grafts":[215],"further":[217],"episodes.":[219],"Univariate":[220],"multivariate":[222],"analysis":[223],"failed":[224],"identify":[226],"clinical":[227],"predictors":[228],"successful":[230],"The":[233,262],"Schol":[234],"B,":[236],"171":[237],"+/-":[238,242,253,259,268,277,290,293,299,302,349,352,358,361],"5.4":[239],"mg/dl":[240],"(mean":[241,327,341],"SEM)":[243],"lower":[245,282],"(P":[246,283,366],"<":[247,284,367],".001)":[248,285,368],"than":[249,286],"A":[251,288],"(249":[252],"10":[254],"mg/dl)":[255,354,363],"or":[256,296],"C":[257,297],"(257":[258],"20":[260],"mg/dl).":[261],"systolic":[263],"BP":[264,273],"B":[266,275],"(108":[267],"2.8":[269],"mmHg)":[270,279,295],"diastolic":[272],"(68":[276],"2.6":[278],"also":[281],"(122":[289],"3.2,":[291],"76":[292],"2.7":[294],"(130":[298],"5,":[300],"80":[301],"3.2":[303],"mmHg),":[304],"respectively.":[305],"No":[306],"difference":[307],"weight":[309],"noted.":[311],"Lipid":[312],"profile":[313],"(total":[314],"chol,":[315,383],"triglyceride,":[316],"HDL,":[317],"VLDL,":[318],"LDL)":[319],"10/14":[323],"age":[328],"sample":[330],"16.25":[331],"years)":[332],"compared":[335],"13":[337],"15.5":[342],"years).":[343],"Both":[344],"total":[346,382],"chol":[347],"(176":[348],"9.2,":[350],"265":[351],"8.3":[353],"LDL":[356,380],"(109":[357],"10,":[359],"167":[360],"9.2":[362],"higher":[365],"group":[371],"pred.":[373],"Based":[374],"our":[376],"findings":[377],"increased":[379,393],"long-term":[386],"atherosclerotic":[396],"disease.":[397]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}