{"id":"https://openalex.org/W2070283156","doi":"https://doi.org/10.1210/me.2008-0146","title":"The Expression of GPIHBP1, an Endothelial Cell Binding Site for Lipoprotein Lipase and Chylomicrons, Is Induced by Peroxisome Proliferator-Activated Receptor-\u03b3","display_name":"The Expression of GPIHBP1, an Endothelial Cell Binding Site for Lipoprotein Lipase and Chylomicrons, Is Induced by Peroxisome Proliferator-Activated Receptor-\u03b3","publication_year":2008,"publication_date":"2008-09-12","ids":{"openalex":"https://openalex.org/W2070283156","doi":"https://doi.org/10.1210/me.2008-0146","mag":"2070283156","pmid":"https://pubmed.ncbi.nlm.nih.gov/18787041","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582544"},"language":"en","primary_location":{"id":"doi:10.1210/me.2008-0146","doi":"https://doi.org/10.1210/me.2008-0146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2008-0146","pdf_url":"https://academic.oup.com/mend/article-pdf/22/11/2496/8937730/mend2496.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/22/11/2496/8937730/mend2496.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068135765","display_name":"Brandon S.J. Davies","orcid":"https://orcid.org/0000-0002-7168-8522","observed_orcids":["https://orcid.org/0000-0002-7168-8522"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brandon S. J. Davies","raw_affiliation_strings":["Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012452289","display_name":"Hironori Waki","orcid":"https://orcid.org/0000-0002-5302-9793","observed_orcids":["https://orcid.org/0000-0002-5302-9793"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hironori Waki","raw_affiliation_strings":["Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090307190","display_name":"Anne P. Beigneux","orcid":"https://orcid.org/0000-0002-7892-150X","observed_orcids":["https://orcid.org/0000-0002-7892-150X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne P. Beigneux","raw_affiliation_strings":["Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082051802","display_name":"Emily Farber","orcid":"https://orcid.org/0000-0003-3474-2304","observed_orcids":["https://orcid.org/0000-0003-3474-2304","https://orcid.org/0000-0003-3931-1781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Farber","raw_affiliation_strings":["Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053017466","display_name":"Michael M. Weinstein","orcid":"https://orcid.org/0009-0001-7492-4009","observed_orcids":["https://orcid.org/0009-0001-7492-4009"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Weinstein","raw_affiliation_strings":["Human Genetics (M.M.W., S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics (M.M.W., S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007036649","display_name":"Damien C. Wilpitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damien C. Wilpitz","raw_affiliation_strings":["Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Jung Tai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Jung Tai","raw_affiliation_strings":["Division of Endocrinology and Metabolism (L.-J.T.), Department of Medicine, University of California, San Diego, La Jolla, California 92093","Gene Expression Laboratory (L.-J.T., R.M.E.), Salk Institute for Biological Studies, La Jolla, California 92037","Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism (L.-J.T.), Department of Medicine, University of California, San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Gene Expression Laboratory (L.-J.T., R.M.E.), Salk Institute for Biological Studies, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087519016","display_name":"Ronald M. Evans","orcid":"https://orcid.org/0000-0002-9986-5965","observed_orcids":["https://orcid.org/0000-0002-9986-5965"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Evans","raw_affiliation_strings":["Gene Expression Laboratory (L.-J.T., R.M.E.), Salk Institute for Biological Studies, La Jolla, California 92037","Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory (L.-J.T., R.M.E.), Salk Institute for Biological Studies, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068606823","display_name":"Loren G. Fong","orcid":"https://orcid.org/0000-0002-4465-5290","observed_orcids":["https://orcid.org/0000-0002-4465-5290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loren G. Fong","raw_affiliation_strings":["Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029940065","display_name":"Peter Tontonoz","orcid":"https://orcid.org/0000-0003-1259-0477","observed_orcids":["https://orcid.org/0000-0003-1259-0477"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Tontonoz","raw_affiliation_strings":["Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute (H.W., D.C.W., L.-J.T., R.M.E., P.T.), La Jolla, California 92037","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine (H.W., D.C.W., P.T.), Los Angeles, California 90095","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085755071","display_name":"Stephen G. Young","orcid":"https://orcid.org/0000-0001-7270-3176","observed_orcids":["https://orcid.org/0000-0001-7270-3176"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Young","raw_affiliation_strings":["Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","Human Genetics (M.M.W., S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine (B.S.J.D., A.P.B., E.F., L.G.F., S.G.Y.), Los Angeles, California 90095","institution_ids":[]},{"raw_affiliation_string":"Human Genetics (M.M.W., S.G.Y.), David Geffen School of Medicine, University of California, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068135765"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9554,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95563288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"11","first_page":"2496","last_page":"2504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpihbp1","display_name":"GPIHBP1","score":1.0},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.6930000185966492},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.902999997138977},{"id":"https://openalex.org/keywords/chylomicrons","display_name":"chylomicrons","score":0.9470000267028809},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fasting-and-refeeding","display_name":"fasting and refeeding","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8040000200271606},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.8009999990463257},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dietary-regulation","display_name":"dietary regulation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.7129999995231628},{"id":"https://openalex.org/keywords/microvascular-endothelium","display_name":"microvascular endothelium","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.8047470450401306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7933838367462158},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6964149475097656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6776700615882874},{"id":"https://openalex.org/C11772777","wikidata":"https://www.wikidata.org/wiki/Q423126","display_name":"Chylomicron","level":5,"score":0.6408854126930237},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5666872262954712},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.507614016532898},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.46294817328453064},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.4260270595550537},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.41494977474212646},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34724003076553345},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.23857513070106506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16445448994636536},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.10397413372993469},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.08930385112762451},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002914","descriptor_name":"Chylomicrons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018110","descriptor_name":"Receptors, Lipoprotein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/me.2008-0146","doi":"https://doi.org/10.1210/me.2008-0146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2008-0146","pdf_url":"https://academic.oup.com/mend/article-pdf/22/11/2496/8937730/mend2496.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2582544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2582544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},{"id":"pmid:18787041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18787041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/me.2008-0146","doi":"https://doi.org/10.1210/me.2008-0146","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2008-0146","pdf_url":"https://academic.oup.com/mend/article-pdf/22/11/2496/8937730/mend2496.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1488855568","display_name":"New Molecules in Triglyceride Metabolism and Adipogenesis","funder_award_id":"P01HL090553","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1676030879","display_name":"Hormonal Regulation of Mammalian Gene Expression","funder_award_id":"R37DK057978","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1909123573","display_name":"Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism","funder_award_id":"R01HL087228","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4007164020","display_name":"NHLBI Bay Area Functional Genomics Consortium","funder_award_id":"U01HL066621","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4375484823","display_name":"Spatial Regulation of Developmental Gene Expression","funder_award_id":"R01HL105278","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6063676648","display_name":"The NHLBI-Bay Area Functional Genomics Consortium","funder_award_id":"U01HL066600","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6501320925","display_name":"Nuclear Receptor Signaling Pathways in Atherogenesis","funder_award_id":"R01HL066088","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7809581868","display_name":"Role of Immune Mechanisms in Athersclerosis and Inflammation","funder_award_id":"P01HL088093","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070283156.pdf","grobid_xml":"https://content.openalex.org/works/W2070283156.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W116324504","https://openalex.org/W1484700968","https://openalex.org/W1672804368","https://openalex.org/W1893140718","https://openalex.org/W1967451520","https://openalex.org/W1976621212","https://openalex.org/W2003859756","https://openalex.org/W2004861205","https://openalex.org/W2005674716","https://openalex.org/W2022174018","https://openalex.org/W2062856054","https://openalex.org/W2063780291","https://openalex.org/W2103116278","https://openalex.org/W2113328569","https://openalex.org/W2117219849","https://openalex.org/W2123247959","https://openalex.org/W2145642828","https://openalex.org/W2164015929","https://openalex.org/W7100917768"],"related_works":["https://openalex.org/W2003247644","https://openalex.org/W1978801803","https://openalex.org/W1967451520","https://openalex.org/W2907745712","https://openalex.org/W2063780291","https://openalex.org/W3009121911","https://openalex.org/W2154326493","https://openalex.org/W1992337083","https://openalex.org/W2029083402","https://openalex.org/W4414645472"],"abstract_inverted_index":{"Glycosylphosphatidylinositol-anchored":[0],"high-density":[1],"lipoprotein-binding":[2],"protein":[3,7],"1":[4,161],"(GPIHBP1),":[5],"a":[6,16,154,165,176],"in":[8,19,90,94,115,133,148,175,183,191,198,208],"the":[9,20,36,59,70,91],"lymphocyte":[10],"antigen":[11],"6":[12],"(Ly-6)":[13],"family,":[14],"plays":[15],"key":[17],"role":[18],"lipolytic":[21],"processing":[22],"of":[23,39,61,136,162],"triglyceride-rich":[24],"lipoproteins.":[25],"GPIHBP1":[26,73,213],"binds":[27],"lipoprotein":[28],"lipase":[29],"and":[30,32,52,81,93,96,103,119,124,145,170,185,219],"chylomicrons":[31],"is":[33,44,53,214],"expressed":[34,132],"along":[35],"luminal":[37],"surface":[38],"microvascular":[40],"endothelial":[41,134,192],"cells.":[42],"Lipolysis":[43],"known":[45],"to":[46],"be":[47,76],"regulated":[48,77,215],"by":[49,78,82,153,216,220],"metabolic":[50],"factors":[51,218],"controlled":[54],"at":[55],"multiple":[56],"levels,":[57],"including":[58],"number":[60],"LPL":[62],"binding":[63,168],"sites":[64],"on":[65],"capillaries.":[66],"Here,":[67],"we":[68],"tested":[69],"possibility":[71],"that":[72,171,203,212],"expression":[74,114,147,207],"could":[75],"dietary":[79,217],"perturbations":[80],"peroxisome":[83],"proliferator-activated":[84],"receptors":[85],"(PPARs).":[86],"Gpihbp1":[87,113,130,146,163,180,206],"transcript":[88,181],"levels":[89,182],"heart":[92],"brown":[95,184],"white":[97,186],"adipose":[98,116,187],"tissue":[99,188],"increased":[100,112],"with":[101],"fasting":[102],"returned":[104],"toward":[105],"baseline":[106],"after":[107],"refeeding.":[108],"A":[109],"PPARgamma":[110,155,194,204],"agonist":[111],"tissue,":[117],"heart,":[118],"skeletal":[120],"muscle,":[121],"whereas":[122],"PPARalpha":[123],"PPARdelta":[125],"agonists":[126],"had":[127],"no":[128],"effect.":[129],"was":[131,151],"cells":[135],"embryoid":[137,149],"bodies":[138,150],"generated":[139],"from":[140,159],"mouse":[141],"embryonic":[142],"stem":[143],"cells,":[144],"up-regulated":[152],"agonist.":[156],"Sequences":[157],"upstream":[158],"exon":[160],"contain":[164],"strong":[166],"PPAR":[167],"site,":[169],"site":[172],"exhibited":[173],"activity":[174],"luciferase":[177],"reporter":[178],"assay.":[179],"were":[189],"lower":[190],"cell":[193],"knockout":[195],"mice":[196],"than":[197],"littermate":[199],"control":[200],"mice,":[201],"suggesting":[202],"regulates":[205],"vivo.":[209],"We":[210],"conclude":[211],"PPARgamma.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}