{"id":"https://openalex.org/W2070143969","doi":"https://doi.org/10.1371/journal.pone.0107513","title":"Expression of the Inherently Autoreactive Idiotope 9G4 on Autoantibodies to Citrullinated Peptides and on Rheumatoid Factors in Patients with Early and Established Rheumatoid Arthritis","display_name":"Expression of the Inherently Autoreactive Idiotope 9G4 on Autoantibodies to Citrullinated Peptides and on Rheumatoid Factors in Patients with Early and Established Rheumatoid Arthritis","publication_year":2014,"publication_date":"2014-09-15","ids":{"openalex":"https://openalex.org/W2070143969","doi":"https://doi.org/10.1371/journal.pone.0107513","mag":"2070143969","pmid":"https://pubmed.ncbi.nlm.nih.gov/25222933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4164660"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0107513","doi":"https://doi.org/10.1371/journal.pone.0107513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0107513","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0107513&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0107513&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072708850","display_name":"Geraldine Cambridge","orcid":"https://orcid.org/0000-0002-6022-6322","observed_orcids":["https://orcid.org/0000-0002-6022-6322"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Geraldine Cambridge","raw_affiliation_strings":["Centre for Rheumatology, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013641276","display_name":"Rita Aguiar Moura","orcid":"https://orcid.org/0000-0002-9685-6924","observed_orcids":["https://orcid.org/0000-0002-9685-6924"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Rita A. Moura","raw_affiliation_strings":["Centre for Rheumatology, University College London, London, United Kingdom; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","Centre for Rheumatology, University College London, London, United Kingdom","Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657222","display_name":"T\u00e2nia C.B. Santos","orcid":"https://orcid.org/0000-0002-4650-0153","observed_orcids":["https://orcid.org/0000-0002-4650-0153"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Tania Santos","raw_affiliation_strings":["Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009546060","display_name":"Akif A. Khawaja","orcid":"https://orcid.org/0000-0003-3267-0482","observed_orcids":["https://orcid.org/0000-0003-3267-0482"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Akif A. Khawaja","raw_affiliation_strings":["Centre for Rheumatology, University College London, London, United Kingdom; Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom","Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom","Centre for Rheumatology, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom; Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084345336","display_name":"Joaquim Polido Pereira","orcid":"https://orcid.org/0000-0002-7188-8516","observed_orcids":["https://orcid.org/0000-0002-7188-8516"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joaquim Polido-Pereira","raw_affiliation_strings":["Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4210149283","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4210149283"]},{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048248640","display_name":"Helena M Canh\u00e3o","orcid":"https://orcid.org/0000-0003-1894-4870","observed_orcids":["https://orcid.org/0000-0003-1894-4870"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Helena Canh\u00e3o","raw_affiliation_strings":["Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4210149283","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4210149283"]},{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082185560","display_name":"Maria Jos\u00e9 Leandro","orcid":"https://orcid.org/0000-0002-2254-4610","observed_orcids":["https://orcid.org/0000-0002-2254-4610"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria J. Leandro","raw_affiliation_strings":["Centre for Rheumatology, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043747371","display_name":"Jo\u00e3o Eurico Fonseca","orcid":"https://orcid.org/0000-0003-1432-3671","observed_orcids":["https://orcid.org/0000-0003-1432-3671"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o E. Fonseca","raw_affiliation_strings":["Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4210149283","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4210149283"]},{"raw_affiliation_string":"Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072708850"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":1023,"currency":"EUR","value_usd":1103},"fwci":1.1578,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76038089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"9","first_page":"e107513","last_page":"e107513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anti-citrullinated-protein-antibodies","display_name":"anti-citrullinated protein antibodies","score":0.8209999799728394},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/autoreactive-b-cells","display_name":"autoreactive B cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/autoantibody-origin","display_name":"autoantibody origin","score":0.5820000171661377},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.49300000071525574},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.49399998784065247},{"id":"https://openalex.org/keywords/plasmablasts","display_name":"plasmablasts","score":0.7110000252723694},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.44999998807907104},{"id":"https://openalex.org/keywords/polyarthritis","display_name":"polyarthritis","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C48660041","wikidata":"https://www.wikidata.org/wiki/Q5989022","display_name":"Idiotopes","level":5,"score":0.9225094318389893},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.9084081649780273},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.8119418621063232},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.62782222032547},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5560629367828369},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5527417659759521},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.5099152326583862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4990086555480957},{"id":"https://openalex.org/C2778917330","wikidata":"https://www.wikidata.org/wiki/Q1274464","display_name":"Polyarthritis","level":3,"score":0.48001164197921753},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.4504859149456024},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.4311334192752838},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41714581847190857},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.39179813861846924},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.26200729608535767},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0107513","doi":"https://doi.org/10.1371/journal.pone.0107513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0107513","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0107513&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:25222933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25222933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4164660","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4164660/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.4090","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.4090","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/21/e4/pone.0107513.PMC4164660.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:65469440ca924de492259054e883faed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/65469440ca924de492259054e883faed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 9, p e107513 (2014)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1448812","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1448812/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One , 9 (9) , Article e107513 . (2014)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/1170321","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Expression_of_the_Inherently_Autoreactive_Idiotope_9G4_on_Autoantibodies_to_Citrullinated_Peptides_and_on_Rheumatoid_Factors_in_Patients_with_Early_and_Established_Rheumatoid_Arthritis_/1170321","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:repositorio.ulisboa.pt:10451/51603","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/51603","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/83468","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/83468","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"9","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0107513","doi":"https://doi.org/10.1371/journal.pone.0107513","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0107513","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0107513&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1844987924","display_name":null,"funder_award_id":"M123-F1","funder_id":"https://openalex.org/F4320320320","funder_display_name":"Rosetrees Trust"},{"id":"https://openalex.org/G870571943","display_name":"THE ROLE OF AUTOREACTIVE 9G4+ B CELLS IN RHEUMATOID ARTHRITIS ONSET AND CLINICAL RELAPSE AFTER TREATMENT","funder_award_id":"SFRH/BPD/81936/2011","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2070143969.pdf","grobid_xml":"https://content.openalex.org/works/W2070143969.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W204003194","https://openalex.org/W1249080388","https://openalex.org/W1515850288","https://openalex.org/W1516636900","https://openalex.org/W1582144994","https://openalex.org/W1935239049","https://openalex.org/W1964503791","https://openalex.org/W1968889356","https://openalex.org/W1980024538","https://openalex.org/W1980036183","https://openalex.org/W1981309359","https://openalex.org/W1987187864","https://openalex.org/W1989114160","https://openalex.org/W1989563648","https://openalex.org/W2003489482","https://openalex.org/W2006547485","https://openalex.org/W2016382347","https://openalex.org/W2024988150","https://openalex.org/W2030497827","https://openalex.org/W2038889701","https://openalex.org/W2040884296","https://openalex.org/W2046047337","https://openalex.org/W2060407329","https://openalex.org/W2062030308","https://openalex.org/W2064349379","https://openalex.org/W2085192554","https://openalex.org/W2092850343","https://openalex.org/W2093028950","https://openalex.org/W2099868898","https://openalex.org/W2107005433","https://openalex.org/W2109578241","https://openalex.org/W2122507029","https://openalex.org/W2136820647","https://openalex.org/W2141301927","https://openalex.org/W2143674339","https://openalex.org/W2145036762","https://openalex.org/W2163206714","https://openalex.org/W2169135987","https://openalex.org/W2187375650","https://openalex.org/W2312932202","https://openalex.org/W2316636274","https://openalex.org/W2438262092","https://openalex.org/W2740171142","https://openalex.org/W2998322151","https://openalex.org/W4231322642","https://openalex.org/W4242287926"],"related_works":["https://openalex.org/W2316636274","https://openalex.org/W2081167100","https://openalex.org/W322554400","https://openalex.org/W2621904819","https://openalex.org/W2952264931","https://openalex.org/W2085192554","https://openalex.org/W2144635104","https://openalex.org/W2024988150","https://openalex.org/W2187975469","https://openalex.org/W2995734501"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,231],"pre-symptomatic":[2],"stage":[3],"of":[4,39,72,83,88,96,154,181,193,199,228,233,236,249,261,282,298],"Rheumatoid":[5,21],"arthritis":[6],"(RA)":[7],"is":[8,77,106,241],"associated":[9,222],"with":[10,138,146,151,203,212,223],"pro-inflammatory":[11],"cytokines":[12],"and":[13,17,24,50,94,149,179,206,220],"autoantibodies.":[14],"High":[15],"levels":[16,42,216,227],"epitope":[18],"spread":[19],"by":[20,45,59,187],"factors":[22,66],"(RhF)":[23],"autoantibodies":[25,60,135,275],"to":[26,57,173,264,279],"citrullinated":[27,175],"proteins":[28],"signify":[29],"progression":[30],"towards":[31],"disease":[32,205],"expression.":[33],"In":[34],"established":[35,147,204,265],"RA,":[36],"the":[37,54,65,70,92,97,107,120,129,182,197,246,258,296,299],"persistence":[38,232],"high":[40],"autoantibody":[41],"reflects":[43],"production":[44],"both":[46],"long-lived":[47],"plasma":[48],"cells":[49],"short-lived":[51],"plasmablasts.":[52],"Neither":[53],"relative":[55],"contributions":[56],"pathogenesis":[58],"from":[61,119,143,201,210,257],"either":[62,157],"source,":[63],"nor":[64],"responsible":[67],"for":[68,293],"deciding":[69],"fate":[71],"autoantigen":[73],"specific":[74],"'parent'":[75],"B-cells,":[76],"understood.":[78],"Phenotypic":[79],"markers":[80],"identifying":[81],"subsets":[82],"autoreactive":[84,122],"B-cells":[85],"are":[86],"therefore":[87,126,288],"interest":[89],"in":[90,100,136,196,208,239,255,302],"understanding":[91],"origin":[93],"perpetuation":[95],"autoimmune":[98,300],"response":[99,301],"RA.":[101,139],"One":[102],"such":[103],"phenotypic":[104],"marker":[105],"rat":[108],"monoclonal":[109],"antibody,":[110],"9G4,":[111],"which":[112],"recognises":[113],"an":[114],"idiotope":[115,131,184],"on":[116,134,252,273],"immunoglobuins":[117],"derived":[118],"inherently":[121],"VH-gene,":[123],"VH4-34.":[124],"We":[125,243],"investigated":[127],"whether":[128],"9G4":[130,183,189,250,271],"was":[132,276],"expressed":[133],"patients":[137,145,202,211,256],"METHODOLOGY/PRINCIPAL":[140],"FINDINGS:":[141],"Sera":[142],"19":[144],"RA":[148,160,262,303],"those":[150],"<1year":[152],"history":[153],"untreated":[155],"polyarthritis":[156],"resolving":[158],"into":[159,295],"(n":[161,167],"=":[162,168],"42)":[163],"or":[164,226],"non-RA":[165],"diagnosis":[166],"31)":[169],"were":[170,185,217],"included.":[171],"Autoantibodies":[172],"cyclic":[174],"peptides":[176],"(CCP),":[177],"RhF":[178],"co-expression":[180],"measured":[186],"ELISA.":[188],"recognised":[190],"a":[191,290],"population":[192],"anti-CCP":[194,253,274],"antibodies":[195,254],"majority":[198],"sera":[200],"also":[207],"samples":[209],"early":[213],"disaese.":[214],"9G4+RhF":[215],"generally":[218],"lower":[219],"not":[221,277],"positivity":[224],"for,":[225],"9G4+CCP.":[229],"CONCLUSIONS/SIGNIFICANCE:":[230],"9G4+":[234],"immunoglobulins,":[235],"any":[237],"isotype,":[238],"serum":[240],"rare.":[242],"describe":[244],"here":[245],"novel":[247],"finding":[248],"expression":[251,272],"earliest":[259],"symptoms":[260],"through":[263],"disease.":[266],"Our":[267],"results":[268],"suggest":[269],"that":[270],"due":[278],"polyclonal":[280],"expansion":[281],"VH4-34-encoded":[283],"immunoglobulins.":[284],"These":[285],"studies":[286],"may":[287],"provide":[289],"new":[291],"focus":[292],"investigation":[294],"evolution":[297],"patients.":[304]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}