{"id":"https://openalex.org/W2070140253","doi":"https://doi.org/10.1016/j.jbiotec.2007.05.022","title":"Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells","display_name":"Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2070140253","doi":"https://doi.org/10.1016/j.jbiotec.2007.05.022","mag":"2070140253","pmid":"https://pubmed.ncbi.nlm.nih.gov/17617485"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbiotec.2007.05.022","doi":"https://doi.org/10.1016/j.jbiotec.2007.05.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbiotec.2007.05.022","pdf_url":null,"source":{"id":"https://openalex.org/S182099265","display_name":"Journal of Biotechnology","issn_l":"0168-1656","issn":["0168-1656","1873-4863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111610451","display_name":"Anssi J. M\u00e4h\u00f6nen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anssi J. M\u00e4h\u00f6nen","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047344858","display_name":"Kari J. Airenne","orcid":"https://orcid.org/0000-0003-3726-4352","observed_orcids":["https://orcid.org/0000-0003-3726-4352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kari J. Airenne","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052853707","display_name":"Sanna Purola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanna Purola","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059403124","display_name":"Erik Peltomaa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik Peltomaa","raw_affiliation_strings":["Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015092410","display_name":"Minna Unelma Kaikkonen","orcid":"https://orcid.org/0000-0001-6294-0979","observed_orcids":["https://orcid.org/0000-0001-6294-0979"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minna U. Kaikkonen","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050189810","display_name":"Mervi S. Riekkinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mervi S. Riekkinen","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046873939","display_name":"Tommi Heikura","orcid":"https://orcid.org/0000-0001-6884-1402","observed_orcids":["https://orcid.org/0000-0001-6884-1402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tommi Heikura","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002292292","display_name":"Kati Kinnunen","orcid":"https://orcid.org/0000-0002-1641-0552","observed_orcids":["https://orcid.org/0000-0002-1641-0552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kati Kinnunen","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047382039","display_name":"Miia M. Roschier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miia M. Roschier","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756658","display_name":"Thomas Wirth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Wirth","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Ark Therapeutics Oy, Neulaniementie 2, FI-70210 Kuopio, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014220812","display_name":"Seppo Yl\u00e4\u2010Herttuala","orcid":"https://orcid.org/0000-0001-7593-2708","observed_orcids":["https://orcid.org/0000-0001-7593-2708"]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Seppo Yl\u00e4-Herttuala","raw_affiliation_strings":["A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","Department of Medicine and Gene Therapy Unit, University of Kuopio and Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.I. Virtanen Institute, Department of Biotechnology and Molecular Medicine, Kuopio, Finland","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine and Gene Therapy Unit, University of Kuopio and Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014220812"],"corresponding_institution_ids":["https://openalex.org/I4210092991"],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":2.3937,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.89407901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"131","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baculovirus-vectors","display_name":"baculovirus vectors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/culture-medium-optimization","display_name":"culture medium optimization","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2781079990","wikidata":"https://www.wikidata.org/wiki/Q8032510","display_name":"Woodchuck hepatitis virus","level":5,"score":0.9785765409469604},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7911170721054077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6886991262435913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6440211534500122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5249281525611877},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5069682598114014},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5021963119506836},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.49865221977233887},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49502962827682495},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.45907753705978394},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31752631068229675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13711345195770264},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.0953013002872467},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.07454675436019897}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016367","descriptor_name":"Baculoviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016367","descriptor_name":"Baculoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016367","descriptor_name":"Baculoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017919","descriptor_name":"Hepatitis B Virus, Woodchuck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jbiotec.2007.05.022","doi":"https://doi.org/10.1016/j.jbiotec.2007.05.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jbiotec.2007.05.022","pdf_url":null,"source":{"id":"https://openalex.org/S182099265","display_name":"Journal of Biotechnology","issn_l":"0168-1656","issn":["0168-1656","1873-4863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biotechnology","raw_type":"journal-article"},{"id":"pmid:17617485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17617485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W28709232","https://openalex.org/W158512522","https://openalex.org/W437229422","https://openalex.org/W1536079214","https://openalex.org/W1574015045","https://openalex.org/W1580526477","https://openalex.org/W1769569140","https://openalex.org/W1963143659","https://openalex.org/W1964315952","https://openalex.org/W1967516426","https://openalex.org/W1968901539","https://openalex.org/W1969341094","https://openalex.org/W1972789608","https://openalex.org/W1982781424","https://openalex.org/W1986903338","https://openalex.org/W1995552531","https://openalex.org/W2000686387","https://openalex.org/W2003833860","https://openalex.org/W2022051395","https://openalex.org/W2022168012","https://openalex.org/W2022650388","https://openalex.org/W2029839079","https://openalex.org/W2030785044","https://openalex.org/W2037390556","https://openalex.org/W2037548392","https://openalex.org/W2039198285","https://openalex.org/W2046147812","https://openalex.org/W2047910969","https://openalex.org/W2050770858","https://openalex.org/W2056535201","https://openalex.org/W2057957370","https://openalex.org/W2069115065","https://openalex.org/W2075470662","https://openalex.org/W2076003033","https://openalex.org/W2081557005","https://openalex.org/W2089023166","https://openalex.org/W2098291790","https://openalex.org/W2103202783","https://openalex.org/W2108876204","https://openalex.org/W2117735652","https://openalex.org/W2121562652","https://openalex.org/W2129464334","https://openalex.org/W2139932658","https://openalex.org/W2142334980","https://openalex.org/W2142700586","https://openalex.org/W2150770791","https://openalex.org/W2166475106","https://openalex.org/W2169561592","https://openalex.org/W2175589106","https://openalex.org/W2276037606","https://openalex.org/W2321908728","https://openalex.org/W2328768986","https://openalex.org/W2475869586"],"related_works":["https://openalex.org/W1769569140","https://openalex.org/W7097628963","https://openalex.org/W2142334980","https://openalex.org/W2056535201","https://openalex.org/W2168270835","https://openalex.org/W3094938241","https://openalex.org/W2054351352","https://openalex.org/W2021304809","https://openalex.org/W2063027828","https://openalex.org/W1975554944"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}