{"id":"https://openalex.org/W2070101581","doi":"https://doi.org/10.1042/bsr20100112","title":"TBC proteins: GAPs for mammalian small GTPase Rab?","display_name":"TBC proteins: GAPs for mammalian small GTPase Rab?","publication_year":2011,"publication_date":"2011-01-14","ids":{"openalex":"https://openalex.org/W2070101581","doi":"https://doi.org/10.1042/bsr20100112","mag":"2070101581","pmid":"https://pubmed.ncbi.nlm.nih.gov/21250943"},"language":"en","primary_location":{"id":"doi:10.1042/bsr20100112","doi":"https://doi.org/10.1042/bsr20100112","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bsr20100112","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006129467","display_name":"Mitsunori Fukuda","orcid":"https://orcid.org/0000-0002-8620-5853","observed_orcids":["https://orcid.org/0000-0002-8620-5853"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsunori Fukuda","raw_affiliation_strings":["Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006129467"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":null,"fwci":1.2228,"has_fulltext":false,"cited_by_count":214,"citation_normalized_percentile":{"value":0.77361702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"31","issue":"3","first_page":"159","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tbc-domain","display_name":"TBC domain","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rab-gtpases","display_name":"Rab GTPases","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tbc1d1","display_name":"TBC1D1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bub2","display_name":"Bub2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cdc16","display_name":"CDC16","score":0.984000027179718},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6940000057220459},{"id":"https://openalex.org/keywords/leanness","display_name":"leanness","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-structure-function-relationship","display_name":"protein structure-function relationship","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.95280921459198},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.8195081353187561},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7290330529212952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5828437805175781},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5058626532554626},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4296623468399048},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4109554886817932},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28364360332489014},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2167229950428009},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2019207775592804}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1042/bsr20100112","doi":"https://doi.org/10.1042/bsr20100112","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bsr20100112","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmid:21250943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21250943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1267229","https://openalex.org/W54074360","https://openalex.org/W66769425","https://openalex.org/W1552824037","https://openalex.org/W1583329442","https://openalex.org/W1967821760","https://openalex.org/W1973200579","https://openalex.org/W1973577506","https://openalex.org/W1974375550","https://openalex.org/W1975396190","https://openalex.org/W1977192546","https://openalex.org/W1981209954","https://openalex.org/W1984121795","https://openalex.org/W1994668150","https://openalex.org/W1994857963","https://openalex.org/W1998691315","https://openalex.org/W2001630263","https://openalex.org/W2008496036","https://openalex.org/W2010688658","https://openalex.org/W2010763118","https://openalex.org/W2012271876","https://openalex.org/W2014064711","https://openalex.org/W2014781571","https://openalex.org/W2032110401","https://openalex.org/W2042200157","https://openalex.org/W2043019778","https://openalex.org/W2045659151","https://openalex.org/W2051702381","https://openalex.org/W2052267637","https://openalex.org/W2054149782","https://openalex.org/W2056048409","https://openalex.org/W2056848617","https://openalex.org/W2060836571","https://openalex.org/W2064782801","https://openalex.org/W2064880862","https://openalex.org/W2066240922","https://openalex.org/W2066933096","https://openalex.org/W2067247420","https://openalex.org/W2067914995","https://openalex.org/W2072698183","https://openalex.org/W2076075378","https://openalex.org/W2081174927","https://openalex.org/W2091821324","https://openalex.org/W2097210443","https://openalex.org/W2099887793","https://openalex.org/W2101118920","https://openalex.org/W2108532908","https://openalex.org/W2108936926","https://openalex.org/W2109530248","https://openalex.org/W2112899867","https://openalex.org/W2117138208","https://openalex.org/W2118356782","https://openalex.org/W2120272671","https://openalex.org/W2124839883","https://openalex.org/W2126660909","https://openalex.org/W2127014382","https://openalex.org/W2129923616","https://openalex.org/W2131097779","https://openalex.org/W2133215208","https://openalex.org/W2143806946","https://openalex.org/W2154218011","https://openalex.org/W2154624747","https://openalex.org/W2157049512","https://openalex.org/W2160489907","https://openalex.org/W2165310868","https://openalex.org/W2166595775","https://openalex.org/W2316977957","https://openalex.org/W2412919812","https://openalex.org/W6635006707","https://openalex.org/W6715008405"],"related_works":["https://openalex.org/W2979614669","https://openalex.org/W3164101786","https://openalex.org/W1980823765","https://openalex.org/W1973577506","https://openalex.org/W2112899867","https://openalex.org/W1984121795","https://openalex.org/W7154850048","https://openalex.org/W2046356479","https://openalex.org/W7097079429","https://openalex.org/W1984973114"],"abstract_inverted_index":{"The":[0,166],"TBC":[1,48,72,93,110,120,176],"(Tre-2/Bub2/Cdc16)":[2,125],"domain":[3,10,49,67,126],"was":[4],"originally":[5],"identified":[6],"as":[7,31,64,85,114],"a":[8,32,65,86,115],"conserved":[9,33],"among":[11],"the":[12,17,47,170],"tre-2":[13],"oncogene":[14],"product":[15],"and":[16,23,25,99,101,130,145,154,161,172],"yeast":[18,51],"cell":[19],"cycle":[20],"regulators":[21],"Bub2":[22],"Cdc16,":[24],"it":[26],"is":[27],"now":[28],"widely":[29],"recognized":[30],"protein":[34],"motif":[35],"that":[36,107],"consists":[37],"of":[38,50,134,174],"approx.":[39],"200":[40],"amino":[41],"acids":[42],"in":[43,77,97,141,143,147,159,164,179],"all":[44],"eukaryotes.":[45],"Since":[46],"Gyps":[52],"[GAP":[53],"(GTPase-activating":[54],"protein)":[55],"for":[56,68],"Ypt":[57],"proteins]":[58],"has":[59,105],"been":[60],"shown":[61],"to":[62,83,181],"function":[63,84,113,173],"GAP":[66],"small":[69,183],"GTPase":[70],"Ypt/Rab,":[71],"domain-containing":[73],"proteins":[74,94,111,121],"(TBC":[75],"proteins)":[76],"other":[78],"species":[79],"are":[80,95,149],"also":[81],"expected":[82],"certain":[87,108],"Rab-GAP.":[88,117],"More":[89],"than":[90],"40":[91],"different":[92],"present":[96,167],"humans":[98],"mice,":[100],"recent":[102],"accumulating":[103],"evidence":[104],"indicated":[106],"mammalian":[109,119,175],"actually":[112],"specific":[116],"Some":[118],"{e.g.":[122],"TBC1D1":[123],"[TBC":[124],"family,":[127],"member":[128],"1]":[129],"TBC1D4/AS160":[131],"(Akt":[132],"substrate":[133],"160":[135],"kDa)}":[136],"play":[137],"an":[138],"important":[139],"role":[140],"homoeostasis":[142],"mammals,":[144],"defects":[146],"them":[148],"directly":[150],"associated":[151],"with":[152],"mouse":[153],"human":[155],"diseases":[156],"(e.g.":[157],"leanness":[158],"mice":[160],"insulin":[162],"resistance":[163],"humans).":[165],"study":[168],"reviews":[169],"structure":[171],"proteins,":[177],"especially":[178],"relation":[180],"Rab":[182],"GTPases.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}