{"id":"https://openalex.org/W2069978422","doi":"https://doi.org/10.1074/jbc.272.33.20636","title":"Upstream Stimulatory Factor-2 (USF2) Activity Is Required for Glucose Stimulation of L-Pyruvate Kinase Promoter Activity in Single Living Islet \u03b2-Cells","display_name":"Upstream Stimulatory Factor-2 (USF2) Activity Is Required for Glucose Stimulation of L-Pyruvate Kinase Promoter Activity in Single Living Islet \u03b2-Cells","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2069978422","doi":"https://doi.org/10.1074/jbc.272.33.20636","mag":"2069978422","pmid":"https://pubmed.ncbi.nlm.nih.gov/9252379"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.33.20636","doi":"https://doi.org/10.1074/jbc.272.33.20636","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.33.20636","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.33.20636","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003965847","display_name":"Helen J. Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen J. Kennedy","raw_affiliation_strings":["Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045765280","display_name":"Beno\u0131\u0302t Viollet","orcid":"https://orcid.org/0000-0002-0121-0224","observed_orcids":["https://orcid.org/0000-0002-0121-0224"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Benoit Viollet","raw_affiliation_strings":["Institut Cochin de Ge\u0301ne\u0301tique Mole\u0301culaire, U. 129 INSERM, Universite\u0301 Rene\u0301Descartes, 24, rue du Faubourg Saint-Jacques, 75 014 Paris, France","University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Cochin de Ge\u0301ne\u0301tique Mole\u0301culaire, U. 129 INSERM, Universite\u0301 Rene\u0301Descartes, 24, rue du Faubourg Saint-Jacques, 75 014 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008230874","display_name":"Imran Rafiq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Imran Rafiq","raw_affiliation_strings":["University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111513695","display_name":"Axel Kahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Axel Kahn","raw_affiliation_strings":["Institut Cochin de Ge\u0301ne\u0301tique Mole\u0301culaire, U. 129 INSERM, Universite\u0301 Rene\u0301Descartes, 24, rue du Faubourg Saint-Jacques, 75 014 Paris, France","University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Cochin de Ge\u0301ne\u0301tique Mole\u0301culaire, U. 129 INSERM, Universite\u0301 Rene\u0301Descartes, 24, rue du Faubourg Saint-Jacques, 75 014 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210141964"]},{"raw_affiliation_string":"University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Guy A. Rutter","raw_affiliation_strings":["University of Bristol, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015737554"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.3905,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.97361237,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"272","issue":"33","first_page":"20636","last_page":"20640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usf2","display_name":"USF2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glucose-stimulation","display_name":"glucose stimulation","score":0.4569999873638153},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7699999809265137},{"id":"https://openalex.org/keywords/e-box","display_name":"E-box","score":0.5649999976158142},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/gene-promoter-activity","display_name":"gene promoter activity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/antibody-microinjection","display_name":"antibody microinjection","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6256967782974243},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5907895565032959},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5818718671798706},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.565241813659668},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.5470222234725952},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5463212132453918},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4977615177631378},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4914613962173462},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.44927653670310974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3595808744430542},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24635997414588928},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.23836177587509155},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23603010177612305},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21965596079826355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15813156962394714},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1574346423149109},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051720","descriptor_name":"Upstream Stimulatory Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.272.33.20636","doi":"https://doi.org/10.1074/jbc.272.33.20636","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.33.20636","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9252379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9252379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/dae33046-650e-44bb-9ab7-7a05e66e07be","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/dae33046-650e-44bb-9ab7-7a05e66e07be","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kennedy, HJ, Viollet, B, Rafiq, I, Kahn, A & Rutter, GA 1997, 'Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet \u03b2 cells', Journal of Biological Chemistry, vol. 272, pp. 20636 - 20640.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:publications/dae33046-650e-44bb-9ab7-7a05e66e07be","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/dae33046-650e-44bb-9ab7-7a05e66e07be","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kennedy, HJ, Viollet, B, Rafiq, I, Kahn, A & Rutter, GA 1997, 'Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet \u03b2 cells', Journal of Biological Chemistry, vol. 272, pp. 20636 - 20640.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.33.20636","doi":"https://doi.org/10.1074/jbc.272.33.20636","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.33.20636","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W645814314","https://openalex.org/W1509867470","https://openalex.org/W1521424334","https://openalex.org/W1527109045","https://openalex.org/W1533715656","https://openalex.org/W1576971163","https://openalex.org/W1769885077","https://openalex.org/W1869102274","https://openalex.org/W1971960342","https://openalex.org/W1974521227","https://openalex.org/W1997134767","https://openalex.org/W2003114121","https://openalex.org/W2028064214","https://openalex.org/W2028102364","https://openalex.org/W2032579724","https://openalex.org/W2043605055","https://openalex.org/W2044884027","https://openalex.org/W2048555922","https://openalex.org/W2063720970","https://openalex.org/W2064483982","https://openalex.org/W2076530564","https://openalex.org/W2084918846","https://openalex.org/W2092993532","https://openalex.org/W2128635872","https://openalex.org/W2140192657","https://openalex.org/W2144634347","https://openalex.org/W2162468227","https://openalex.org/W2171975928","https://openalex.org/W2314225431"],"related_works":["https://openalex.org/W1997134767","https://openalex.org/W307201496","https://openalex.org/W1993700780","https://openalex.org/W2416870789","https://openalex.org/W1982378715","https://openalex.org/W2404506793","https://openalex.org/W2006479619","https://openalex.org/W2236585110","https://openalex.org/W1831559887","https://openalex.org/W2052526508"],"abstract_inverted_index":{"Elevated":[0],"glucose":[1,15,122,155,195],"concentrations":[2],"stimulate":[3],"L-pyruvate":[4],"kinase":[5],"(L-PK)":[6],"gene":[7,198],"transcription":[8,139,199],"in":[9,79,116,146,168,200],"liver":[10],"and":[11,27,84,88,148,176],"islet":[12,82],"beta-cells.":[13],"A":[14],"response":[16],"element":[17],"termed":[18],"the":[19,33,42,47,50,53,91,95,108,137,178,192,204,211],"L4":[20,187,213],"box":[21],"(two":[22],"noncanonical":[23],"E-boxes":[24],"located":[25],"-165":[26],"-154":[28],"base":[29],"pairs":[30],"upstream":[31,212],"of":[32,46,52,70,94,134,180,207],"transcriptional":[34],"start":[35],"point)":[36],"has":[37],"previously":[38],"been":[39],"defined":[40],"within":[41],"proximal":[43],"promoter":[44,76,100,105,144,166,183],"region":[45],"gene.":[48],"However,":[49],"identity":[51],"transacting":[54],"factor(s)":[55],"which":[56],"binds":[57],"to":[58,74,89,103,210],"this":[59],"site":[60],"remains":[61],"unclear.":[62],"We":[63],"have":[64],"used":[65],"photon":[66],"counting":[67],"digital":[68],"imaging":[69],"firefly":[71],"luciferase":[72],"activity":[73,77,106,145,167,179],"monitor":[75],"continuously":[78],"single":[80],"living":[81],"beta":[83],"derived":[85],"INS-1":[86,149,169],"cells,":[87],"analyze":[90],"molecular":[92],"basis":[93],"regulation":[96],"by":[97,156,202],"glucose.":[98,132],"L-PK":[99,143,197],"activity,":[101],"normalized":[102],"cytomegalovirus":[104],"using":[107],"distinct":[109],"Renilla":[110],"reniformis":[111],"luciferase,":[112],"was":[113],">/=6-fold":[114],"higher":[115],"cells":[117,127,150,170],"cultured":[118,128,171],"at":[119,129,152,172],"16":[120],"mM":[121,131,154,174],"or":[123],"above":[124],"compared":[125],"with":[126],"3":[130,173],"Microinjection":[133],"antibodies":[135,159],"against":[136],"ubiquitous":[138],"factor":[140],"USF2":[141,208],"inhibited":[142],"beta-":[147],"incubated":[151],"30":[153],"71-87%.":[157],"Anti-USF2":[158],"had":[160],"a":[161,181],"much":[162],"smaller":[163],"effect":[164],"on":[165,177],"glucose,":[175],"modified":[182],"construct":[184],"lacking":[185],"an":[186],"box.":[188,214],"These":[189],"data":[190],"support":[191],"view":[193],"that":[194],"enhances":[196],"beta-cells":[201],"modifying":[203],"transactivational":[205],"capacity":[206],"bound":[209]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}