{"id":"https://openalex.org/W2069942756","doi":"https://doi.org/10.1097/00004714-199606002-00001","title":"Synaptic Effects of Antidepressants","display_name":"Synaptic Effects of Antidepressants","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2069942756","doi":"https://doi.org/10.1097/00004714-199606002-00001","mag":"2069942756","pmid":"https://pubmed.ncbi.nlm.nih.gov/8784643"},"language":"en","primary_location":{"id":"doi:10.1097/00004714-199606002-00001","doi":"https://doi.org/10.1097/00004714-199606002-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004714-199606002-00001","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012485525","display_name":"Elliott Richelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"ELLIOTT RICHELSON","raw_affiliation_strings":["Department of Research, Mayo Clinic Jacksonville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Mayo Clinic Jacksonville, Florida, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012485525"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"],"apc_list":null,"apc_paid":null,"fwci":4.5482,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.95013323,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"16","issue":"SUPPLEMENT 2","first_page":"1S","last_page":"7S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9580000042915344},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9779999852180481},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.8100000023841858},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pathophysiology-of-depression","display_name":"depression pathophysiology","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4117535948753357},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36634111404418945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3590691089630127},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2759258449077606}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004714-199606002-00001","doi":"https://doi.org/10.1097/00004714-199606002-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004714-199606002-00001","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:8784643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8784643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1850609236","https://openalex.org/W1970421748","https://openalex.org/W1975377762","https://openalex.org/W1979293025","https://openalex.org/W1982292219","https://openalex.org/W2023205673","https://openalex.org/W2074335684","https://openalex.org/W2121086028"],"related_works":["https://openalex.org/W68645225","https://openalex.org/W4297675113","https://openalex.org/W1994074679","https://openalex.org/W1223311551","https://openalex.org/W1983680715","https://openalex.org/W2479983893","https://openalex.org/W2012470414","https://openalex.org/W174095768","https://openalex.org/W3137773541","https://openalex.org/W2487918941"],"abstract_inverted_index":{"Catecholamines,":[0],"especially":[1],"norepinephrine":[2],"(NE)":[3],"and":[4,20,60,62,93,136,161],"serotonin":[5],"(5-hydroxytryptamine":[6],"[5-HT]),":[7],"have":[8,28,116],"been":[9],"implicated":[10],"in":[11,131],"the":[12,32,37,41,43,53,87,100,113,148,157],"pathophysiology":[13],"of":[14,40,47,52,55,64,76,82,102,123,143,151,164],"depression.":[15],"However,":[16,107],"their":[17,21],"exact":[18],"roles":[19],"interrelationship":[22],"are":[23,50,129],"not":[24],"completely":[25],"understood.":[26],"Antidepressants":[27],"various":[29],"effects":[30,49,118,128,135,150,160],"on":[31],"body,":[33],"including":[34,57],"action":[35],"at":[36],"neuronal":[38],"synapses":[39],"brain;":[42],"two":[44],"most":[45],"important":[46,130],"these":[48,165],"blockade":[51,63],"reuptake":[54,101],"neurotransmitters,":[56],"NE,":[58],"5-HT,":[59],"dopamine,":[61],"certain":[65,133],"neurotransmitter":[66,85],"receptors.":[67],"Currently":[68],"available":[69],"antidepressants":[70,92],"may":[71],"be":[72],"classified":[73],"as":[74,80,112],"inhibitors":[75],"monoamine":[77],"oxidase":[78],"or":[79,104],"blockers":[81],"biogenic":[83],"amine":[84],"reuptake,":[86],"latter":[88],"best":[89],"describing":[90],"tricyclic":[91],"selective":[94],"5-HT-reuptake":[95],"inhibitors,":[96,115],"because":[97],"they":[98],"block":[99],"one":[103],"more":[105],"neurotransmitters.":[106],"recently":[108],"introduced":[109],"antidepressants,":[110],"such":[111],"5-HT-NE-reuptake":[114],"synaptic":[117,127,149],"that":[119],"differ":[120],"from":[121],"those":[122],"older":[124],"compounds.":[125],"These":[126],"explaining":[132],"side":[134,159],"drug-drug":[137],"interactions":[138],"associated":[139],"with":[140],"all":[141],"classes":[142],"antidepresants.":[144],"This":[145],"article":[146],"reviews":[147],"marketed":[152],"antidepressant":[153],"agents":[154],"to":[155],"elucidate":[156],"anticipated":[158],"drug-interaction":[162],"potential":[163],"agents.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
