{"id":"https://openalex.org/W2069934531","doi":"https://doi.org/10.1097/ftd.0000000000000053","title":"Unexpected Overestimation of Methotrexate Plasma Concentrations: Analysis of a Single Center Pediatric Population","display_name":"Unexpected Overestimation of Methotrexate Plasma Concentrations: Analysis of a Single Center Pediatric Population","publication_year":2014,"publication_date":"2014-07-11","ids":{"openalex":"https://openalex.org/W2069934531","doi":"https://doi.org/10.1097/ftd.0000000000000053","mag":"2069934531","pmid":"https://pubmed.ncbi.nlm.nih.gov/25014075"},"language":"en","primary_location":{"id":"doi:10.1097/ftd.0000000000000053","doi":"https://doi.org/10.1097/ftd.0000000000000053","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0000000000000053","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044654877","display_name":"Emilie Guerriero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210104040","display_name":"H\u00f4pital Jeanne de Flandre","ror":"https://ror.org/01e8kn913","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]},{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Emilie Guerriero","raw_affiliation_strings":["*Department of Pharmacy, Lille University Hospital; \u2020Department of Antitumoral Pharmacology, Centre Oscar Lambret; \u2021EA4481-GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University; \u00a7Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital; and \u00b6Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France","Department of Pharmacy, Lille University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Pharmacy, Lille University Hospital; \u2020Department of Antitumoral Pharmacology, Centre Oscar Lambret; \u2021EA4481-GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University; \u00a7Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital; and \u00b6Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France","institution_ids":["https://openalex.org/I4210104040","https://openalex.org/I4210131356"]},{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105980317","display_name":"Nicolas Simon","orcid":"https://orcid.org/0000-0001-5257-440X","observed_orcids":["https://orcid.org/0000-0001-5257-440X"]},"institutions":[{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Simon","raw_affiliation_strings":["Department of Antitumoral Pharmacology, Centre Oscar Lambret;","EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","Department of Antitumoral Pharmacology, Centre Oscar Lambret; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antitumoral Pharmacology, Centre Oscar Lambret;","institution_ids":["https://openalex.org/I4210131356"]},{"raw_affiliation_string":"EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","institution_ids":["https://openalex.org/I59807433"]},{"raw_affiliation_string":"Department of Antitumoral Pharmacology, Centre Oscar Lambret; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University","institution_ids":["https://openalex.org/I4210131356","https://openalex.org/I59807433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067815591","display_name":"Brigitte Nelken","orcid":"https://orcid.org/0000-0003-1048-1517","observed_orcids":["https://orcid.org/0000-0003-1048-1517"]},"institutions":[{"id":"https://openalex.org/I4210104040","display_name":"H\u00f4pital Jeanne de Flandre","ror":"https://ror.org/01e8kn913","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210104040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte Nelken","raw_affiliation_strings":["Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital; and","Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital; and","institution_ids":["https://openalex.org/I4210104040"]},{"raw_affiliation_string":"Department of Paediatric Haematology, Jeanne de Flandres Hospital, Lille University Hospital","institution_ids":["https://openalex.org/I4210104040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020219173","display_name":"Brigitte Baldeyrou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte Baldeyrou","raw_affiliation_strings":["Department of Antitumoral Pharmacology, Centre Oscar Lambret"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Antitumoral Pharmacology, Centre Oscar Lambret","institution_ids":["https://openalex.org/I4210131356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032622658","display_name":"Bodale Djobo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bodal\u00e9 Djobo","raw_affiliation_strings":["Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091803749","display_name":"Mich\u00e8le Vasseur","orcid":"https://orcid.org/0000-0001-7580-3471","observed_orcids":["https://orcid.org/0000-0001-7580-3471"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mich\u00e8le Vasseur","raw_affiliation_strings":["Department of Pharmacy, Lille University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020677444","display_name":"Delphine Allorge","orcid":"https://orcid.org/0000-0003-2356-3319","observed_orcids":["https://orcid.org/0000-0003-2356-3319"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Allorge","raw_affiliation_strings":["Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Biology and Pathology Center, Lille University Hospital, France","institution_ids":["https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056245796","display_name":"Bertrand D\u00e9caudin","orcid":"https://orcid.org/0000-0001-8267-5594","observed_orcids":["https://orcid.org/0000-0001-8267-5594"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Bertrand D\u00e9caudin","raw_affiliation_strings":["Department of Pharmacy, Lille University Hospital","EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","Department of Pharmacy, Lille University Hospital; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","institution_ids":["https://openalex.org/I59807433"]},{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University","institution_ids":["https://openalex.org/I59807433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080988761","display_name":"Pascal Odou","orcid":"https://orcid.org/0000-0003-1555-6530","observed_orcids":["https://orcid.org/0000-0003-1555-6530"]},"institutions":[{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I59807433","display_name":"Universit\u00e9 Lille Nord de France","ror":"https://ror.org/03btvgn05","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970","https://openalex.org/I59807433"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascal Odou","raw_affiliation_strings":["Department of Pharmacy, Lille University Hospital","EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","Department of Pharmacy, Lille University Hospital; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University;","institution_ids":["https://openalex.org/I59807433"]},{"raw_affiliation_string":"Department of Pharmacy, Lille University Hospital; EA4481\u2014GRIIOT, Department of Biopharmacy, Galenic and Hospital Pharmacy, Faculty of Pharmacy, Lille Nord-de-France University","institution_ids":["https://openalex.org/I59807433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044654877","https://openalex.org/A5056245796","https://openalex.org/A5080988761","https://openalex.org/A5091803749"],"corresponding_institution_ids":["https://openalex.org/I3018718406","https://openalex.org/I4210104040","https://openalex.org/I4210131356","https://openalex.org/I59807433"],"apc_list":null,"apc_paid":null,"fwci":1.2256,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79132726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"36","issue":"4","first_page":"499","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/fluorescence-polarization-immunoassay","display_name":"fluorescence polarization immunoassay","score":0.9599999785423279},{"id":"https://openalex.org/keywords/emit-immunoassay","display_name":"EMIT immunoassay","score":0.8330000042915344},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.6470000147819519},{"id":"https://openalex.org/keywords/analytical-error","display_name":"analytical error","score":0.36399999260902405},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6627898216247559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4436585605144501},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4314863979816437},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.42362499237060547},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.41436487436294556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32970672845840454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2809038758277893},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06332886219024658},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016231","descriptor_name":"Fluorescence Polarization Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/ftd.0000000000000053","doi":"https://doi.org/10.1097/ftd.0000000000000053","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ftd.0000000000000053","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:25014075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25014075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1664168469","https://openalex.org/W1891730290","https://openalex.org/W1966006831","https://openalex.org/W2043460432","https://openalex.org/W2079070878","https://openalex.org/W2085087016","https://openalex.org/W2151573345","https://openalex.org/W2152829853","https://openalex.org/W6639439297"],"related_works":["https://openalex.org/W2068429678","https://openalex.org/W2725898427","https://openalex.org/W2294880519","https://openalex.org/W2399471741","https://openalex.org/W2130705999","https://openalex.org/W2492743894","https://openalex.org/W2038376244","https://openalex.org/W2349257298","https://openalex.org/W2366822374","https://openalex.org/W2326437565"],"abstract_inverted_index":{"BACKGROUND:":[0],"At":[1],"this":[2,47,292],"center,":[3],"therapeutic":[4],"drug":[5],"monitoring":[6],"of":[7,24,37,46,77,113,117,154,182,245,266,270,277,291],"methotrexate":[8],"(MTX)":[9],"used":[10,107],"to":[11,42,127,166,274,287],"be":[12,275],"performed":[13,230],"by":[14,158],"fluorescence":[15],"polarization":[16],"immunoassay":[17],"(FPIA).":[18],"We":[19],"observed":[20,251],"an":[21,114,128,167],"increasing":[22],"number":[23],"unusual":[25],"high":[26],"MTX":[27,67,78,183,254,260,271],"concentrations":[28,79,186],"at":[29,82,192,242],"48":[30,83,193],"and":[31,62,85,91,96,134,144,172,189,195,200,204,211,235],"72":[32,86,201],"hours":[33,87,202],"during":[34,220],"a":[35,102],"couple":[36],"years.":[38],"This":[39],"study":[40,222,283],"aimed":[41],"identify":[43],"the":[44,118,121,155,159,180,221,225,243,253,267,278,289,296],"causes":[45],"variation.":[48],"METHODS:":[49],"A":[50,99,281],"retrospective":[51],"analysis":[52],"was":[53,70,89,106,123,177,272],"conducted":[54],"on":[55,295],"272":[56],"patients":[57],"hospitalized":[58],"between":[59,93,187],"January":[60],"2008":[61],"October":[63],"2012.":[64],"The":[65,75,152,248,264],"whole":[66],"use":[68],"system":[69],"analyzed":[71],"using":[72],"Ishikawa's":[73],"method.":[74],"proportion":[76],"\u22640.2":[80,184],"\u03bcmole/L":[81,185],"(P48h)":[84],"(P72h)":[88],"recorded":[90],"compared":[92],"both":[94,170,246],"FPIA":[95,119,188],"EMITSiemens":[97,156],"assays.":[98],"\u03c7":[100],"or":[101],"Fisher":[103],"exact":[104],"test":[105],"(\u03b1":[108],"=":[109,198,207],"0.05).":[110],"RESULTS:":[111],"Because":[112],"announced":[115],"withdrawal":[116],"reagent,":[120],"method":[122],"switched":[124],"in":[125,163,169,179,252],"2009":[126,139],"immunoenzymatic":[129],"technique":[130],"(EMITSiemens).":[131],"Both":[132,209],"P48h":[133,171],"P72h":[135],"dropped":[136],"significantly":[137],"after":[138],"(P48h:":[140],"45%":[141],"versus":[142,147],"5%":[143],"P72h:":[145],"91%":[146],"47%;":[148],"P":[149,197,206],"<":[150],"0.0001).":[151],"replacement":[153],"reagent":[157,162],"EMITARK":[160,190],"Diagnostics":[161,191],"2012":[164],"led":[165],"increase":[168],"P72h.":[173],"No":[174],"significant":[175],"difference":[176],"found":[178],"proportions":[181],"(45%":[194],"40%;":[196],"0.556)":[199],"(91%":[203],"100%;":[205],"0.231).":[208],"internal":[210,232],"external":[212],"quality":[213,233],"control":[214],"assessments":[215],"gave":[216],"regular":[217],"satisfactory":[218],"results":[219,241],"period.":[223],"Furthermore,":[224],"interassay":[226],"comparisons":[227],"that":[228],"were":[229,256],"with":[231,259],"controls":[234],"spiked":[236],"serum":[237],"samples":[238],"showed":[239],"similar":[240],"time":[244],"shifts.":[247],"other":[249],"changes":[250],"circuit":[255],"not":[257],"associated":[258],"concentration":[261,269],"variations.":[262],"CONCLUSIONS:":[263],"overestimation":[265],"plasma":[268],"concluded":[273],"because":[276],"assay":[279],"reagent.":[280],"further":[282],"is":[284],"consequently":[285],"necessary":[286],"assess":[288],"impact":[290],"analytical":[293],"pitfall":[294],"patients'":[297],"survival.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
