{"id":"https://openalex.org/W2069877303","doi":"https://doi.org/10.1158/1538-7445.am2012-364","title":"Abstract 364: In vivo targeting of CD44+ ovarian cancer stem cells (CSC) by Clostridium Perfringens Enterotoxin binding domain (CPE-peptide) conjugated to poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP)","display_name":"Abstract 364: In vivo targeting of CD44+ ovarian cancer stem cells (CSC) by Clostridium Perfringens Enterotoxin binding domain (CPE-peptide) conjugated to poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP)","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2069877303","doi":"https://doi.org/10.1158/1538-7445.am2012-364","mag":"2069877303"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-364","doi":"https://doi.org/10.1158/1538-7445.am2012-364","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-364","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041993659","display_name":"Emiliano Cocco","orcid":"https://orcid.org/0000-0002-1397-2656","observed_orcids":["https://orcid.org/0000-0002-1397-2656"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emiliano Cocco","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046857977","display_name":"Stefania Bellone","orcid":"https://orcid.org/0000-0001-5909-5292","observed_orcids":["https://orcid.org/0000-0001-5909-5292"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefania Bellone","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052390359","display_name":"Dana M. Roque","orcid":"https://orcid.org/0000-0002-7098-6376","observed_orcids":["https://orcid.org/0000-0002-7098-6376"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Roque","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063469601","display_name":"Federica Guzzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Federica Guzzo","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087338346","display_name":"Sara Gasparrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Gasparrini","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103016982","display_name":"Sergio L. Pecorelli","orcid":"https://orcid.org/0000-0002-5126-4300","observed_orcids":["https://orcid.org/0000-0002-5126-4300"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Pecorelli","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108433612","display_name":"Dan\u2010Arin Silasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan-Arin Silasi","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032849063","display_name":"Masoud Azodi","orcid":"https://orcid.org/0000-0002-0570-8089","observed_orcids":["https://orcid.org/0000-0002-0570-8089"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoud Azodi","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021257078","display_name":"Elena Ratner","orcid":"https://orcid.org/0000-0002-6277-6002","observed_orcids":["https://orcid.org/0000-0002-6277-6002"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Ratner","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014978402","display_name":"Thomas Ruterford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Ruterford","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026827320","display_name":"Peter E. Schwartz","orcid":"https://orcid.org/0000-0002-0845-3624","observed_orcids":["https://orcid.org/0000-0002-0845-3624"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Schwartz","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087767215","display_name":"Caroline E. Weller","orcid":"https://orcid.org/0009-0000-0381-3822","observed_orcids":["https://orcid.org/0009-0000-0381-3822"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline E. Weller","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010339370","display_name":"Alessandro Davide Santin","orcid":"https://orcid.org/0000-0003-4724-9738","observed_orcids":["https://orcid.org/0000-0003-4724-9738"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro D. Santin","raw_affiliation_strings":["1Yale Univ., New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale Univ., New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"364","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer-stem-cells","display_name":"ovarian cancer stem cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.984000027179718},{"id":"https://openalex.org/keywords/clostridium-perfringens-enterotoxin","display_name":"Clostridium perfringens enterotoxin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/claudin-4","display_name":"claudin-4","score":0.859000027179718},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.8849999904632568},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nanoparticle-biodistribution","display_name":"nanoparticle biodistribution","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.5590000152587891},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.7950000166893005},{"id":"https://openalex.org/keywords/scid-mouse-xenograft","display_name":"SCID mouse xenograft","score":0.6380000114440918},{"id":"https://openalex.org/keywords/intraperitoneal-tumor","display_name":"intraperitoneal tumor","score":0.6510000228881836},{"id":"https://openalex.org/keywords/coumarin-6","display_name":"coumarin 6","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.74555504322052},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6019105315208435},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5384848117828369},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5042763948440552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4816238284111023},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.4279943108558655},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4250616431236267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4177928566932678},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4154052734375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40534713864326477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3932439386844635},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38512441515922546},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32728102803230286},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27498313784599304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19933095574378967},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19146788120269775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17217350006103516},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-364","doi":"https://doi.org/10.1158/1538-7445.am2012-364","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-364","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2323268294","https://openalex.org/W2565055093","https://openalex.org/W2017751746","https://openalex.org/W2566910113","https://openalex.org/W1982723015","https://openalex.org/W2055836462","https://openalex.org/W1985448148","https://openalex.org/W1984951401","https://openalex.org/W2314459358","https://openalex.org/W3016864769"],"abstract_inverted_index":{"Abstract":[0],"Recent":[1],"evidence":[2],"strongly":[3],"supports":[4],"the":[5,8,37,55,84,97,115,126,222,233,284,303,313,364,369],"hypothesis":[6,42],"that":[7,312],"capability":[9],"to":[10,17,51,164,175,257,293,317,343],"sustain":[11],"tumor":[12,29,202,289],"formation,":[13],"growth":[14],"and":[15,53,125,154,186,269,288],"resistance":[16],"chemotherapy":[18],"in":[19,24,76,98,127,137,156,169,243,247,279,323,331],"ovarian":[20,57,78,123,143,171,216,328,348],"cancer":[21,32],"exclusively":[22],"resides":[23],"a":[25,61,151,239],"small":[26],"proportion":[27],"of":[28,46,71,102,119,130,159,184,198,229,236,299,363,368],"cells":[30,34,203],"termed":[31],"stem":[33],"(CSC)":[35],"overexpressing":[36,214,326],"CD44":[38],"marker.":[39],"If":[40],"this":[41,81],"is":[43,83],"correct,":[44],"development":[45],"novel,":[47],"more":[48],"specific":[49,276],"approaches":[50],"target":[52,345],"eradicate":[54],"CD44+":[56,77,142,170,215,327,347],"CSC":[58,124,144,172,217,329,349],"population":[59],"remains":[60],"high":[62,69,86,321],"priority.":[63],"Our":[64],"group":[65],"has":[66],"recently":[67],"reported":[68],"expression":[70],"claudin-4":[72,213,325],"tight":[73],"junction":[74],"protein":[75,82],"CSC.":[79],"Because":[80],"natural":[85],"affinity":[87],"receptor":[88],"for":[89,350,372],"Clostridium":[90],"Perfringens":[91],"Enterotoxin":[92],"(CPE),":[93],"we":[94,149],"have":[95],"evaluated":[96],"vitro":[99,157],"targeting":[100,324],"potential":[101],"fluorescent":[103,160],"(i.e.":[104],"Coumarin":[105],"6":[106],"loaded)":[107],"poly(lactic-co-glycolic":[108],"acid)":[109],"(PLGA)":[110],"nanoparticles":[111],"(NP)":[112],"conjugated":[113,163,316],"with":[114,226,253],"C-terminus":[116],"binding":[117],"domain":[118],"CPE":[120,165],"(CPE-peptide)":[121],"against":[122],"vivo":[128],"biodistribution":[129],"these":[131,309],"NP":[132,162,177,200,205,231,255,262,277,301,334],"after":[133,204,261,297],"intravenous":[134],"(IV)":[135,225],"injection":[136,298],"SCID":[138,210],"mice":[139,211,251],"harboring":[140,212],"intraperitoneal":[141],"tumor.":[145],"Using":[146],"flow":[147],"cytometry,":[148],"report":[150],"higher":[152],"time":[153],"dose-dependent":[155],"uptake":[158,278],"PLGA":[161],"peptide":[166],"(CPE-peptide":[167],"NP)":[168],"when":[173,209,315],"compared":[174,256],"unconjugated":[176,237,304],"(i.e.,":[178],"control":[179,305],"NP,":[180,238,318],"Mean-Fluorescence-Intensity":[181],"=":[182],"MFI":[183],"37.1":[185],"15.0":[187],"respectively;":[188,272],"p=0.037).":[189],"Of":[190],"interest,":[191],"confocal":[192],"microcopy":[193],"images":[194],"clearly":[195],"show":[196],"internalization":[197],"CPE-peptide":[199,230,254,300,333],"within":[201],"exposure.":[206],"More":[207],"importantly,":[208],"tumors":[218,248,330],"were":[219],"injected":[220,252],"via":[221],"tail":[223],"vein":[224],"25":[227],"\u03bcg/g":[228],"or":[232],"same":[234],"concentration":[235],"4":[240],"fold":[241],"increase":[242],"fluorescence":[244,290],"was":[245,291],"detected":[246],"excised":[249],"from":[250],"controls":[258],"48":[259],"hours":[260],"administration":[263],"(mean":[264],"\u00b1":[265],"STDV":[266],"33159.6":[267],"2707":[268],"6655.8":[270],"\u00b11391":[271],"p<0.01).":[273],"Finally,":[274],"non":[275],"healthy":[280],"organs":[281,287],"calculated":[282],"as":[283],"ratio":[285],"between":[286],"found":[292],"be":[294],"significantly":[295],"lower":[296],"than":[302],"NP.":[306],"Taken":[307],"together":[308],"results":[310],"suggest":[311],"CPE-peptide,":[314],"may":[319,335],"confer":[320],"specificity":[322],"vivo.":[332],"represent":[336],"an":[337],"unconventional,":[338],"potentially":[339],"highly":[340],"effective":[341],"strategy":[342],"specifically":[344],"chemotherapy-resistant":[346],"diagnostic":[351],"and/or":[352],"therapeutic":[353],"purposes.":[354],"Citation":[355],"Format:":[356],"{Authors}.":[357],"{Abstract":[358],"title}":[359],"[abstract].":[360],"In:":[361],"Proceedings":[362],"103rd":[365],"Annual":[366],"Meeting":[367],"American":[370],"Association":[371],"Cancer":[373,384],"Research;":[374],"2012":[375],"Mar":[376],"31-Apr":[377],"4;":[378],"Chicago,":[379],"IL.":[380],"Philadelphia":[381],"(PA):":[382],"AACR;":[383],"Res":[385],"2012;72(8":[386],"Suppl):Abstract":[387],"nr":[388],"364.":[389],"doi:1538-7445.AM2012-364":[390]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}