{"id":"https://openalex.org/W2069834634","doi":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","title":"Microbial stimulation as an aetiologic factor in atopic disease","display_name":"Microbial stimulation as an aetiologic factor in atopic disease","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2069834634","doi":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","mag":"2069834634","pmid":"https://pubmed.ncbi.nlm.nih.gov/10422742"},"language":"en","primary_location":{"id":"doi:10.1111/j.1398-9995.1999.tb04382.x","doi":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Microbial_stimulation_as_an_aetiologic_factor_in_atopic_disease/20611950","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017272011","display_name":"Patrick G. Holt","orcid":"https://orcid.org/0000-0003-1193-0935","observed_orcids":["https://orcid.org/0000-0003-1193-0935"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"P. G. Holt","raw_affiliation_strings":["Division of Cell Biology, TVW Telethon Institute for Child Health Research, West Perth, Australia. patrick@ichr.uwa.edu.au","Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, TVW Telethon Institute for Child Health Research, West Perth, Australia. patrick@ichr.uwa.edu.au","institution_ids":["https://openalex.org/I175234967"]},{"raw_affiliation_string":"Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia","institution_ids":["https://openalex.org/I175234967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011835721","display_name":"Claudia Macaubas","orcid":"https://orcid.org/0000-0002-5472-8086","observed_orcids":["https://orcid.org/0000-0002-5472-8086"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C. Macaubas","raw_affiliation_strings":["Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia","institution_ids":["https://openalex.org/I175234967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077492180","display_name":"Susan L. Prescott","orcid":"https://orcid.org/0000-0003-4845-8590","observed_orcids":["https://orcid.org/0000-0003-4845-8590"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. L. Prescott","raw_affiliation_strings":["Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia","institution_ids":["https://openalex.org/I175234967"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048175603","display_name":"Peter David Sly","orcid":"https://orcid.org/0000-0001-6305-2201","observed_orcids":["https://orcid.org/0000-0001-6305-2201"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P. D. Sly","raw_affiliation_strings":["Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, TVW Telethon Institute for Child Health Rescarch, West Perth, Australia","institution_ids":["https://openalex.org/I175234967"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017272011"],"corresponding_institution_ids":["https://openalex.org/I175234967"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":4.0078,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94013372,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"54","issue":"s49","first_page":"12","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0940999984741211,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbial-exposure","display_name":"microbial exposure","score":0.7929999828338623},{"id":"https://openalex.org/keywords/atopic-diseases","display_name":"atopic diseases","score":0.8320000171661377},{"id":"https://openalex.org/keywords/atopic-sensitization","display_name":"atopic sensitization","score":0.6140000224113464},{"id":"https://openalex.org/keywords/early-childhood","display_name":"early childhood","score":0.5889999866485596},{"id":"https://openalex.org/keywords/respiratory-allergy","display_name":"respiratory allergy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/aeroallergens","display_name":"aeroallergens","score":0.9549999833106995},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6542978286743164},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.601840615272522},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5695129632949829},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.5612086653709412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5045634508132935},{"id":"https://openalex.org/C131140426","wikidata":"https://www.wikidata.org/wiki/Q900521","display_name":"Intoxicative inhalant","level":2,"score":0.48745250701904297},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4826551079750061},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.4587574005126953},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.35766369104385376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32174569368362427},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.27850010991096497},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27808064222335815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11253577470779419},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10553684830665588},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1016741394996643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09652233123779297},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007121","descriptor_name":"Immunocompetence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018743","descriptor_name":"Perinatal Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1398-9995.1999.tb04382.x","doi":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","pdf_url":null,"source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"pmid:10422742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10422742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/ea1c19b3-edc0-4e7f-8ede-ee3e860ab35d","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/ea1c19b3-edc0-4e7f-8ede-ee3e860ab35d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Holt, P G, Macaubas, C, Prescott, S & Sly, P 1999, 'Microbial stimulation as an aetiologic factor in atopic disease', Allergy, vol. 54, no. Supplement 49, pp. 12S-16S. https://doi.org/10.1111/j.1398-9995.1999.tb04382.x","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/20611950","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Microbial_stimulation_as_an_aetiologic_factor_in_atopic_disease/20611950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/20611950","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Microbial_stimulation_as_an_aetiologic_factor_in_atopic_disease/20611950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1487602178","https://openalex.org/W1524217669","https://openalex.org/W1538658476","https://openalex.org/W1658116990","https://openalex.org/W1964913168","https://openalex.org/W1966679064","https://openalex.org/W1983895762","https://openalex.org/W1992108141","https://openalex.org/W2002924338","https://openalex.org/W2016357017","https://openalex.org/W2028353803","https://openalex.org/W2035580952","https://openalex.org/W2035831689","https://openalex.org/W2036870810","https://openalex.org/W2053703074","https://openalex.org/W2059662032","https://openalex.org/W2067047380","https://openalex.org/W2075942059","https://openalex.org/W2083536542","https://openalex.org/W2087906095","https://openalex.org/W2095450757","https://openalex.org/W2108257606","https://openalex.org/W2115516360","https://openalex.org/W2120012263","https://openalex.org/W2132690754","https://openalex.org/W2133188511","https://openalex.org/W2144281476","https://openalex.org/W2145236284","https://openalex.org/W2158906570","https://openalex.org/W2159997401","https://openalex.org/W2161450196","https://openalex.org/W2163813388","https://openalex.org/W2171345725","https://openalex.org/W2172466148","https://openalex.org/W2784641565","https://openalex.org/W4237439965"],"related_works":["https://openalex.org/W2053703074","https://openalex.org/W2054908654","https://openalex.org/W4382046262","https://openalex.org/W7096562402","https://openalex.org/W2398650586","https://openalex.org/W4315471631","https://openalex.org/W4283076428","https://openalex.org/W2324685020","https://openalex.org/W1989004929","https://openalex.org/W2017851233"],"abstract_inverted_index":{"Epidemiologic":[0],"evidence":[1,52],"from":[2],"various":[3],"sources":[4],"suggests":[5],"that":[6],"exposure":[7],"to":[8,37,55,72],"microbial":[9],"stimuli":[10],"during":[11],"early":[12],"childhood":[13],"can":[14],"influence":[15],"the":[16,25,40,56,66],"induction":[17],"and":[18],"expression":[19,38],"of":[20,39,50,68],"atopic":[21,41],"diseases,":[22],"particularly":[23],"in":[24,35,43,53,64],"respiratory":[26],"tract.":[27],"Moreover,":[28],"these":[29],"effects":[30],"may":[31],"have":[32],"long-lasting":[33],"consequences":[34],"relation":[36,54],"phenotype":[42],"adulthood.":[44],"This":[45],"review":[46],"discusses":[47],"key":[48],"aspects":[49],"this":[51],"underlying":[57],"mechanisms":[58],"which":[59],"regulate":[60],"T-helper":[61],"(Th)-cell":[62],"function;":[63],"particular,":[65],"generation":[67],"Th-memory":[69],"cells":[70],"responsive":[71],"inhalant":[73],"allergens.":[74]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
