{"id":"https://openalex.org/W206978487","doi":null,"title":"TDP-43 in aging and Alzheimer's disease - a review.","display_name":"TDP-43 in aging and Alzheimer's disease - a review.","publication_year":2011,"publication_date":"2011-01-30","ids":{"openalex":"https://openalex.org/W206978487","mag":"206978487","pmid":"https://pubmed.ncbi.nlm.nih.gov/21326809","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037200"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3037200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110231471","display_name":"Andrea C. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea C Wilson","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847199","display_name":"Brittany N. Dugger","orcid":"https://orcid.org/0000-0003-2141-8855","observed_orcids":["https://orcid.org/0000-0003-2141-8855"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany N Dugger","raw_affiliation_strings":["Mayo Clinic Jacksonville (FL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Jacksonville (FL)","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009533777","display_name":"Dennis W. Dickson","orcid":"https://orcid.org/0000-0001-7189-7917","observed_orcids":["https://orcid.org/0000-0001-7189-7917"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis W Dickson","raw_affiliation_strings":["Mayo Clinic Jacksonville (FL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Jacksonville (FL)","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110186269","display_name":"Deng-Shun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deng-Shun Wang","raw_affiliation_strings":["University of Wisconsin, Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3733,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.98551616,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"2","first_page":"147","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.718999981880188},{"id":"https://openalex.org/keywords/proteinopathies","display_name":"proteinopathies","score":0.7110000252723694},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ftld-tdp","display_name":"FTLD-TDP","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hippocampal-sclerosis","display_name":"hippocampal sclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuronal-inclusions","display_name":"neuronal inclusions","score":0.7289999723434448},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.8849964141845703},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7374044060707092},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5717355608940125},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5522029995918274},{"id":"https://openalex.org/C2777597344","wikidata":"https://www.wikidata.org/wiki/Q4421929","display_name":"Hippocampal sclerosis","level":4,"score":0.5377618670463562},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5348685383796692},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5205296277999878},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.47751039266586304},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4730619192123413},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.46072959899902344},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45804518461227417},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4474126696586609},{"id":"https://openalex.org/C2777898937","wikidata":"https://www.wikidata.org/wiki/Q5008447","display_name":"C9orf72","level":5,"score":0.42993441224098206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42280739545822144},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4119494557380676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38858675956726074},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3801232576370239},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1819409728050232},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.09639778733253479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0776689350605011},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057177","descriptor_name":"TDP-43 Proteinopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057177","descriptor_name":"TDP-43 Proteinopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057177","descriptor_name":"TDP-43 Proteinopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3037200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:21326809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21326809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:206978487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21326809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3037200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3037200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1023730781","display_name":"Biological and clinical significance of tTG and isopeptide in AD","funder_award_id":"R21AG029972","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4033720201","display_name":"Einstein Aging Study","funder_award_id":"P01AG003949","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7425391916","display_name":"Tau and Neurodegeneration II: A therapeutic target","funder_award_id":"P01AG017216","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7774046770","display_name":"Genetics and Molecular Biology of Parkinsonism","funder_award_id":"P50NS072187","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1542765837","https://openalex.org/W1619082318","https://openalex.org/W1966364136","https://openalex.org/W1967932847","https://openalex.org/W1974298458","https://openalex.org/W1975860260","https://openalex.org/W1977311503","https://openalex.org/W1978122964","https://openalex.org/W1984145170","https://openalex.org/W1989448189","https://openalex.org/W1990145006","https://openalex.org/W1995276702","https://openalex.org/W2000584920","https://openalex.org/W2000897776","https://openalex.org/W2003618511","https://openalex.org/W2005731595","https://openalex.org/W2010268863","https://openalex.org/W2011543201","https://openalex.org/W2012526287","https://openalex.org/W2021206757","https://openalex.org/W2027460468","https://openalex.org/W2027720028","https://openalex.org/W2028471696","https://openalex.org/W2032719480","https://openalex.org/W2037214298","https://openalex.org/W2044184260","https://openalex.org/W2044468792","https://openalex.org/W2044676388","https://openalex.org/W2045962406","https://openalex.org/W2047061352","https://openalex.org/W2047265916","https://openalex.org/W2047798094","https://openalex.org/W2051218719","https://openalex.org/W2055013864","https://openalex.org/W2065140753","https://openalex.org/W2066952414","https://openalex.org/W2072413533","https://openalex.org/W2073164785","https://openalex.org/W2074795212","https://openalex.org/W2075588816","https://openalex.org/W2078616043","https://openalex.org/W2079504310","https://openalex.org/W2083031173","https://openalex.org/W2084561728","https://openalex.org/W2089588548","https://openalex.org/W2092646825","https://openalex.org/W2098219309","https://openalex.org/W2102901087","https://openalex.org/W2104658204","https://openalex.org/W2106775021","https://openalex.org/W2107754763","https://openalex.org/W2115672510","https://openalex.org/W2115694724","https://openalex.org/W2116660354","https://openalex.org/W2117597459","https://openalex.org/W2125948889","https://openalex.org/W2127861463","https://openalex.org/W2131725903","https://openalex.org/W2134408741","https://openalex.org/W2136305293","https://openalex.org/W2137048103","https://openalex.org/W2139267086","https://openalex.org/W2146913804","https://openalex.org/W2151521848","https://openalex.org/W2152585035","https://openalex.org/W2154417593","https://openalex.org/W2160475742","https://openalex.org/W2163955717","https://openalex.org/W2169092675"],"related_works":["https://openalex.org/W4200192644","https://openalex.org/W4385441981","https://openalex.org/W3208120386","https://openalex.org/W2076179375","https://openalex.org/W4309367316","https://openalex.org/W2886042688","https://openalex.org/W4404256402","https://openalex.org/W3092556119","https://openalex.org/W1737594935","https://openalex.org/W2525541800"],"abstract_inverted_index":{"Transactive":[0],"response":[1],"DNA-binding":[2],"protein":[3,13],"of":[4,31,71,97,131,137,168,217],"43":[5],"kDa":[6],"(TDP-43),":[7],"an":[8,151,215],"RNA":[9,18,21],"and":[10,20,39,60,85,107,134,227,231,243],"DNA":[11],"binding":[12],"involved":[14],"in":[15,34,68,93,154,170,194,206,223,228,238],"transcriptional":[16],"repression,":[17],"splicing":[19],"metabolism":[22],"during":[23],"the":[24,28,132,160,182],"stress":[25],"response,":[26],"is":[27,91,122,149,186,204,219],"major":[29],"component":[30],"neuronal":[32,126],"inclusions":[33],"amyotrophic":[35],"lateral":[36],"sclerosis":[37,119],"(ALS)":[38],"frontotemporal":[40],"lobar":[41],"degeneration":[42],"with":[43,77,102,117,139],"ubiquitin":[44],"inclusions,":[45],"now":[46,65],"referred":[47],"to":[48,54,58,95,159],"as":[49,112,114],"FTLD-TDP.":[50],"While":[51],"initially":[52],"thought":[53],"be":[55,236],"relatively":[56],"specific":[57],"ALS":[59],"FTLD-TDP,":[61],"TDP-43":[62,89,144,147,169,202,222,234],"pathology":[63,90,148,203],"has":[64],"been":[66],"detected":[67,92],"a":[69,189],"number":[70],"other":[72,229],"neurodegenerative":[73],"diseases,":[74],"many":[75],"associated":[76],"tau":[78],"pathology,":[79,111],"including":[80],"Guam":[81],"Parkinson":[82],"dementia":[83],"complex":[84],"Alzheimer's":[86],"disease":[87],"(AD).":[88],"25%":[94],"50%":[96],"AD":[98,115,155],"cases,":[99],"especially":[100],"those":[101],"more":[103,161],"severe":[104,162],"clinical":[105,163],"phenotype":[106,164],"greater":[108],"Alzheimer":[109],"type":[110],"well":[113],"cases":[116,136],"hippocampal":[118],"(HS).":[120],"HS":[121],"characterized":[123],"by":[124],"selective":[125],"loss":[127],"affecting":[128],"CA1":[129],"sector":[130],"hippocampus,":[133],"most":[135],"HS,":[138],"or":[140,156,191,211],"without":[141],"AD,":[142,179,224],"have":[143],"pathology.":[145],"Whether":[146],"merely":[150,188],"incidental":[152,192],"finding":[153,193],"actually":[157],"contributing":[158],"remains":[165],"unresolved.":[166],"Presence":[167],"normal":[171,208,225],"elderly,":[172],"who":[173],"are":[174],"at":[175],"increased":[176],"risk":[177],"for":[178],"would":[180],"strengthen":[181],"argument":[183],"that":[184,201,233],"it":[185],"not":[187],"secondary":[190],"end":[195],"stage":[196],"AD.":[197],"Limited":[198],"studies":[199],"suggest":[200,232],"infrequent":[205],"neurologically":[207],"elderly":[209],"(3%":[210],"less).":[212],"We":[213],"provide":[214],"overview":[216],"what":[218],"known":[220],"about":[221],"aging":[226],"disorders":[230],"proteinopathies":[235],"considered":[237],"two":[239],"classes":[240],"-":[241],"primary":[242],"secondary.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
