{"id":"https://openalex.org/W2069770489","doi":"https://doi.org/10.7448/ias.15.6.18064","title":"Benefits of ART simplification on adherence, clinical and economic outcomes","display_name":"Benefits of ART simplification on adherence, clinical and economic outcomes","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2069770489","doi":"https://doi.org/10.7448/ias.15.6.18064","mag":"2069770489","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3512537"},"language":"en","primary_location":{"id":"doi:10.7448/ias.15.6.18064","doi":"https://doi.org/10.7448/ias.15.6.18064","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.15.6.18064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.15.6.18064","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.15.6.18064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Vera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257607","display_name":"Hospital de Cascais Dr Jos\u00e9 de Almeida","ror":"https://ror.org/05f1jmk63","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405257607"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J Vera","raw_affiliation_strings":["Centro Hospitalar de Cascais, Cascais, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Hospitalar de Cascais, Cascais, Portugal","institution_ids":["https://openalex.org/I4405257607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090613628","display_name":"Filipa Arag\u00e3o","orcid":"https://orcid.org/0000-0003-3446-6725","observed_orcids":["https://orcid.org/0000-0003-3446-6725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Arag\u00e3o","raw_affiliation_strings":["Escola Nacional de Sau\u0301de Pu\u0301blica and Associac\u0327a\u0303o SER+, Lisbon, Portugal","Escola Nacional de Sa\u00fade P\u00fablica and Associa\u00e7\u00e3o SER+, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escola Nacional de Sau\u0301de Pu\u0301blica and Associac\u0327a\u0303o SER+, Lisbon, Portugal","institution_ids":[]},{"raw_affiliation_string":"Escola Nacional de Sa\u00fade P\u00fablica and Associa\u00e7\u00e3o SER+, Lisbon, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Guimaraes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257607","display_name":"Hospital de Cascais Dr Jos\u00e9 de Almeida","ror":"https://ror.org/05f1jmk63","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405257607"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M Guimaraes","raw_affiliation_strings":["Centro Hospitalar de Cascais, Cascais, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Hospitalar de Cascais, Cascais, Portugal","institution_ids":["https://openalex.org/I4405257607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035295096","display_name":"In\u00eas Vaz Pinto","orcid":"https://orcid.org/0000-0002-6281-8591","observed_orcids":["https://orcid.org/0000-0002-6281-8591"]},"institutions":[{"id":"https://openalex.org/I4405257607","display_name":"Hospital de Cascais Dr Jos\u00e9 de Almeida","ror":"https://ror.org/05f1jmk63","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405257607"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"I Vaz Pinto","raw_affiliation_strings":["Centro Hospitalar de Cascais, Cascais, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Hospitalar de Cascais, Cascais, Portugal","institution_ids":["https://openalex.org/I4405257607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.6694,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68768003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"S4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-therapy-simplification","display_name":"antiretroviral therapy simplification","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.9129999876022339},{"id":"https://openalex.org/keywords/single-tablet-regimen","display_name":"single-tablet regimen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antiretroviral-therapy-adherence","display_name":"antiretroviral therapy adherence","score":0.7440000176429749},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.9359999895095825},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":0.753000020980835},{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.6190000176429749},{"id":"https://openalex.org/keywords/economic-outcomes","display_name":"economic outcomes","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8806064128875732},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8018214702606201},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.5259433388710022},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5217305421829224},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5093733072280884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49540483951568604},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.46074095368385315},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4549417793750763},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4396836757659912},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.42903172969818115},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.4145585894584656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22430971264839172},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.17127454280853271},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.15394654870033264}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7448/ias.15.6.18064","doi":"https://doi.org/10.7448/ias.15.6.18064","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.15.6.18064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.15.6.18064","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3512537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3512537/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int AIDS Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7448/ias.15.6.18064","doi":"https://doi.org/10.7448/ias.15.6.18064","is_oa":true,"landing_page_url":"https://doi.org/10.7448/ias.15.6.18064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.7448/IAS.15.6.18064","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2069770489.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2791490441","https://openalex.org/W4390529607","https://openalex.org/W2134444048","https://openalex.org/W2584986959","https://openalex.org/W2743679826","https://openalex.org/W2003927521","https://openalex.org/W2898783407","https://openalex.org/W2774925837","https://openalex.org/W2000416073","https://openalex.org/W2167422033"],"abstract_inverted_index":{"Purpose":[0],"of":[1,23,43,59,72,110,117,160,166,184,197,270,290,313,322,338,358,369],"the":[2,19,41,70,94,115,158,164,230,267,367],"study":[3,351],"Fixed\u2010dose":[4],"combinations":[5],"(FDCs)":[6],"and":[7,38,49,89,102,114,119,149,171,210,218,236,257,277,293,301,306,316,355,363,372,380],"single\u2010tablet":[8],"regimens":[9,162,328,375],"(STRs)":[10,46],"may":[11],"reduce":[12],"complete":[13],"non\u2010adherence":[14,26,91],"(CNA)":[15],"but":[16,29],"also":[17,154],"have":[18],"potential":[20],"additional":[21],"benefit":[22],"avoiding":[24,361],"partial":[25],"(PNA)":[27],"(some":[28],"not":[30],"all":[31],"drugs":[32],"taken).":[33],"We":[34],"test":[35,82],"this":[36],"hypothesis":[37],"then":[39],"estimate":[40],"impact":[42,116,159],"PNA\u2010free":[44,161,374],"regimen":[45,147,220],"on":[47,121,163,172,191],"clinical":[48,379],"economic":[50,381],"outcomes.":[51],"Methods":[52],"The":[53,79,108,176,186,319],"unit":[54,205],"analysis":[55,177,188,269],"was":[56,67,83,178,189,214,222,226,247,275,329],"a":[57,195,288],"person\u2010regimen":[58],"2":[60],"NRTI+(NNRTI,":[61],"PI/r)":[62],"lasting":[63],"\u226590":[64],"days.":[65],"Adherence":[66],"measured":[68],"by":[69],"proportion":[71],"days":[73],"covered":[74],"using":[75,127],"pharmacy":[76],"refill":[77],"data.":[78],"Wilcoxon":[80],"rank\u2010sum":[81],"used":[84,155],"to":[85,156,285,299,310,346],"compare":[86],"CNA,":[87],"PNA":[88,118,246,307,362],"total":[90],"(TNA)":[92],"in":[93,180,202,206,229,238,249,287,296,360],"following":[95],"groups:":[96],"STR":[97,241,261],"vs":[98,104,106,233,240,243,254,263,272,326],"its":[99],"components":[100],"(EFV+TDF/FTC)":[101],"non\u2010FDC":[103,231,250,300],"FDC":[105,239,252,354],"STR.":[107],"level":[109],"adherence":[111],"per":[112],"group":[113],"CNA":[120,225,305],"virological":[122,370],"failure":[123],"(VF)":[124],"were":[125,308,333],"estimated":[126,284],"multivariate":[128],"regression":[129],"panel":[130],"data":[131],"models":[132],"(MVRPDM).":[133],"Control":[134],"variables":[135],"included":[136],"age,":[137],"gender,":[138],"hepatitis":[139],"co\u2010infection,":[140],"cumulative":[141],"comorbidity":[142],"score,":[143],"CD4,":[144],"viral":[145],"load,":[146],"duration":[148,221],"calendar":[150],"year.":[151],"MVRPDM":[152],"we":[153],"access":[157],"probability":[165,368],"at":[167],"least":[168],"one":[169,203],"hospitalization":[170,323],"annualized":[173,340],"hospitalization+ART":[174],"costs.":[175],"performed":[179,190],"Stata":[181],"11\u00ae.":[182],"Summary":[183],"results":[185],"retrospective":[187],"2,449":[192],"person\u2010regimens":[193],"from":[194],"cohort":[196],"1,435":[198],"HIV\u2010infected":[199],"individuals":[200],"followed":[201],"HIV":[204],"Portugal,":[207],"between":[208],"2001":[209],"2011.":[211],"Median":[212],"age":[213],"38":[215],"years":[216],"old":[217],"median":[219],"1.9":[223],"years.":[224],"higher":[227,248],"(23%)":[228],"(p<0.001":[232,262,315],"other":[234,264,327,347],"groups)":[235],"similar":[237],"(15%":[242],"11%,":[244],"p=0.951).":[245],"than":[251],"(4.2%":[253],"3.4%;":[255],"p=0.020)":[256],"obviously":[258],"null":[259],"with":[260,324,335,378],"groups).":[265],"In":[266,280],"subgroup":[268],"EFV+FTC/TDF":[271],"STR,":[273],"TNA":[274,297],"16%":[276],"11%":[278,291],"(p=0.0025).":[279],"MVRPDM,":[281],"STRs":[282,325,332,356],"are":[283,357,376],"result":[286],"decrease":[289],"(p<0.001)":[292,295],"5.3%":[294],"relatively":[298],"FDC,":[302],"respectively.":[303],"Both":[304],"found":[309],"be":[311],"predictors":[312],"VF":[314],"p=0.020,":[317],"respectively).":[318],"odds":[320],"ratio":[321],"0.33":[330],"(p=0.019).":[331],"associated":[334,377],"lower":[336],"sum":[337],"ART+hospitalization":[339],"costs":[341],"(\u22121,330\u20ac;":[342],"p<0.001)":[343],"when":[344],"compared":[345],"regimens.":[348],"Conclusions":[349],"This":[350],"suggests":[352],"that":[353,373],"value":[359],"TNA,":[364],"thereby":[365],"reducing":[366],"failure,":[371],"benefits.":[382]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
