{"id":"https://openalex.org/W2069750720","doi":"https://doi.org/10.3892/ijmm.18.4.751","title":"A conditionally replicative adenovirus that codes for a TK-GFP fusion protein (Ad5\u039424TK-GFP) for evaluation of the potency of oncolytic virotherapy combined with molecular chemotherapy","display_name":"A conditionally replicative adenovirus that codes for a TK-GFP fusion protein (Ad5\u039424TK-GFP) for evaluation of the potency of oncolytic virotherapy combined with molecular chemotherapy","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W2069750720","doi":"https://doi.org/10.3892/ijmm.18.4.751","mag":"2069750720","pmid":"https://pubmed.ncbi.nlm.nih.gov/16964432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2203218"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.18.4.751","doi":"https://doi.org/10.3892/ijmm.18.4.751","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.18.4.751","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.18.4.751/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.spandidos-publications.com/10.3892/ijmm.18.4.751/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111747486","display_name":"Tanja Hakkarainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tanja Hakkarainen","raw_affiliation_strings":["Rational Drug Design Program, University of Helsinki, 00014 University of Helsinki, Helsinki, Finland.  tanja.m.hakkarainen@helsinki.fi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rational Drug Design Program, University of Helsinki, 00014 University of Helsinki, Helsinki, Finland.  tanja.m.hakkarainen@helsinki.fi","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062078543","display_name":"Akseli Hemminki","orcid":"https://orcid.org/0000-0001-7103-8530","observed_orcids":["https://orcid.org/0000-0001-7103-8530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akseli Hemminki","raw_affiliation_strings":["Research Programs Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Programs Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Curiel","raw_affiliation_strings":["Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, and Obstetrics and Gynecology and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th St. S., Birmingham, AL 35294-2172, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, and Obstetrics and Gynecology and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th St. S., Birmingham, AL 35294-2172, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078234561","display_name":"Jarmo Wahlfors","orcid":"https://orcid.org/0000-0003-2716-2870","observed_orcids":["https://orcid.org/0000-0003-2716-2870"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jarmo Wahlfors","raw_affiliation_strings":["Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, 70211 Kuopio;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, 70211 Kuopio;","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5065,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.93254007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"4","first_page":"751","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conditionally-replicating-adenovirus","display_name":"conditionally replicating adenovirus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/thymidine-kinase","display_name":"thymidine kinase","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-penetration","display_name":"tumor penetration","score":0.5509999990463257},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6159999966621399},{"id":"https://openalex.org/keywords/oncolysis","display_name":"oncolysis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9238704442977905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6901562213897705},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.6212016344070435},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5900253057479858},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.585409939289093},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5260063409805298},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5131576657295227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5115383863449097},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4905385375022888},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.4800739884376526},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.4221230745315552},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41151660680770874},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34077757596969604},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3049960136413574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21521592140197754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05575057864189148}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijmm.18.4.751","doi":"https://doi.org/10.3892/ijmm.18.4.751","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.18.4.751","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.18.4.751/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:16964432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16964432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2203218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2203218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Mol Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ijmm.18.4.751","doi":"https://doi.org/10.3892/ijmm.18.4.751","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.18.4.751","pdf_url":"https://www.spandidos-publications.com/10.3892/ijmm.18.4.751/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4311721979","display_name":"Enhanced CRAd for Pancreatic Cancer","funder_award_id":"R01CA094084","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5636123545","display_name":null,"funder_award_id":"5 R01 CA940484-03","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6751111239","display_name":"Replicative adenoviruses with enhanced infectivity","funder_award_id":"R01CA083821","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8627455277","display_name":"Canine model for evaluating CRAD efficacy","funder_award_id":"R01CA093796","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320323824","display_name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","ror":"https://ror.org/05pgg4z49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069750720.pdf","grobid_xml":"https://content.openalex.org/works/W2069750720.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W49311282","https://openalex.org/W1558969188","https://openalex.org/W1581549015","https://openalex.org/W1582164157","https://openalex.org/W1781724529","https://openalex.org/W1808107661","https://openalex.org/W1934461291","https://openalex.org/W1953788830","https://openalex.org/W1958134681","https://openalex.org/W1968603674","https://openalex.org/W1973504318","https://openalex.org/W1991882807","https://openalex.org/W2003634190","https://openalex.org/W2006202262","https://openalex.org/W2025768863","https://openalex.org/W2029080338","https://openalex.org/W2029484094","https://openalex.org/W2037561205","https://openalex.org/W2044700629","https://openalex.org/W2046035469","https://openalex.org/W2053621712","https://openalex.org/W2053981403","https://openalex.org/W2068724951","https://openalex.org/W2073134590","https://openalex.org/W2087133379","https://openalex.org/W2095418304","https://openalex.org/W2103810198","https://openalex.org/W2108309692","https://openalex.org/W2110592777","https://openalex.org/W2124127443","https://openalex.org/W2138710378","https://openalex.org/W2138863592","https://openalex.org/W2142305690","https://openalex.org/W2145606454","https://openalex.org/W2148231564","https://openalex.org/W2153389806","https://openalex.org/W2156383817","https://openalex.org/W2156754275","https://openalex.org/W2167259192","https://openalex.org/W2189257102","https://openalex.org/W2321167123","https://openalex.org/W2323062703","https://openalex.org/W2444572374","https://openalex.org/W2530496919","https://openalex.org/W4231880025"],"related_works":["https://openalex.org/W2119707632","https://openalex.org/W2124285937","https://openalex.org/W2002480565","https://openalex.org/W2087133379","https://openalex.org/W1968674236","https://openalex.org/W2028627047","https://openalex.org/W2279767525","https://openalex.org/W2141274600","https://openalex.org/W7096485708","https://openalex.org/W2102994497"],"abstract_inverted_index":{"The":[0],"utility":[1],"of":[2,45,90,120,151,188],"conditionally":[3],"replicative":[4],"adenoviruses":[5],"(CRAds)":[6],"in":[7,23,52,92,105,109,127,134,161,186],"cancer":[8,106],"gene":[9,67],"therapy":[10],"is":[11,75],"based":[12],"on":[13,100,175],"their":[14],"ability":[15],"to":[16,25,32,41,48,145,170],"destroy":[17],"tumor":[18,36,73,136],"cells":[19,107],"by":[20,38,77,141],"oncolysis.":[21,157],"However,":[22],"order":[24],"achieve":[26],"adequate":[27],"therapeutic":[28],"response,":[29],"CRAds":[30],"have":[31],"spread":[33],"through":[34],"the":[35,43,87,95,118,176],"tissue":[37],"replication.":[39],"Thus,":[40],"study":[42],"potency":[44],"these":[46],"viruses":[47],"replicate":[49],"and":[50,111,172],"penetrate":[51,114],"tumors,":[53],"we":[54,85],"created":[55],"a":[56,78],"herpes":[57],"simplex":[58],"virus":[59,147],"type":[60],"1":[61],"thymidine":[62],"kinase-green":[63],"fluorescent":[64],"protein":[65],"fusion":[66],"(TK-GFP)":[68],"encompassing":[69],"CRAd":[70],"(Ad5Delta24TK-GFP),":[71],"whose":[72],"selectivity":[74],"mediated":[76],"retinoblastoma":[79],"(Rb)-binding":[80],"site":[81],"mutation.":[82],"In":[83],"addition,":[84],"evaluated":[86],"oncolytic":[88],"efficacy":[89],"Ad5Delta24TK-GFP":[91,103,123],"combination":[93,119],"with":[94,122],"TK/ganciclovir":[96],"(GCV)":[97],"system.":[98],"Based":[99],"our":[101],"results,":[102],"replicates":[104],"resulting":[108],"oncolysis":[110,142],"can":[112],"efficiently":[113],"into":[115],"tumors.":[116],"Additionally,":[117],"GCV":[121,152],"augmented":[124],"cell":[125,165],"death":[126],"vitro":[128],"but":[129,149],"this":[130],"was":[131,138],"not":[132,154],"observed":[133],"vivo:":[135],"growth":[137],"significantly":[139,155],"reduced":[140],"when":[143],"compared":[144],"non-replicative":[146],"(p<0.001),":[148],"administration":[150],"did":[153],"enhance":[156],"This":[158],"suggests":[159],"that":[160],"certain":[162],"conditions,":[163],"TK/GCV-mediated":[164],"killing":[166],"may":[167],"be":[168,180],"counterproductive":[169],"replication":[171],"oncolysis,":[173],"which":[174],"other":[177],"hand":[178],"might":[179],"useful":[181],"feature":[182],"for":[183],"clinical":[184],"trials":[185],"case":[187],"replication-associated":[189],"toxicity.":[190]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
