{"id":"https://openalex.org/W2069701438","doi":"https://doi.org/10.1038/sj.bjc.6603636","title":"Cellular senescence and chromatin organisation","display_name":"Cellular senescence and chromatin organisation","publication_year":2007,"publication_date":"2007-02-20","ids":{"openalex":"https://openalex.org/W2069701438","doi":"https://doi.org/10.1038/sj.bjc.6603636","mag":"2069701438","pmid":"https://pubmed.ncbi.nlm.nih.gov/17311013","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360064"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6603636","doi":"https://doi.org/10.1038/sj.bjc.6603636","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603636","pdf_url":"https://www.nature.com/articles/6603636.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6603636.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086264006","display_name":"Masashi Narita","orcid":"https://orcid.org/0000-0001-7764-577X","observed_orcids":["https://orcid.org/0000-0001-7764-577X"]},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M Narita","raw_affiliation_strings":["Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK. masashi.narita@cancer.org.uk","Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK. masashi.narita@cancer.org.uk","institution_ids":["https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK","institution_ids":["https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086264006"],"corresponding_institution_ids":["https://openalex.org/I2801316944"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.4638,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.43830334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"5","first_page":"686","last_page":"691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chromatin-biology","display_name":"chromatin biology","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8682119250297546},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8531056046485901},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.7649953365325928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6387884020805359},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6056291460990906},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.543339192867279},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.540440022945404},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5128350853919983},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.4117697477340698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3219224214553833},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13644015789031982},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10667812824249268},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.10085684061050415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06206554174423218},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjc.6603636","doi":"https://doi.org/10.1038/sj.bjc.6603636","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603636","pdf_url":"https://www.nature.com/articles/6603636.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2360064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:17311013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17311013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.281.3645","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.281.3645","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/79/0b/Br_J_Cancer_2007_Mar_12_96(5)_686-691.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6603636","doi":"https://doi.org/10.1038/sj.bjc.6603636","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6603636","pdf_url":"https://www.nature.com/articles/6603636.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069701438.pdf","grobid_xml":"https://content.openalex.org/works/W2069701438.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1493066387","https://openalex.org/W1965124005","https://openalex.org/W1970891016","https://openalex.org/W1982395176","https://openalex.org/W1990161819","https://openalex.org/W1998466286","https://openalex.org/W2012315992","https://openalex.org/W2027931017","https://openalex.org/W2037920955","https://openalex.org/W2038878300","https://openalex.org/W2041036994","https://openalex.org/W2047330128","https://openalex.org/W2054647745","https://openalex.org/W2055322019","https://openalex.org/W2061619522","https://openalex.org/W2065564965","https://openalex.org/W2067117191","https://openalex.org/W2078281194","https://openalex.org/W2080769506","https://openalex.org/W2081807421","https://openalex.org/W2082541706","https://openalex.org/W2084289371","https://openalex.org/W2086603476","https://openalex.org/W2087404852","https://openalex.org/W2103419911","https://openalex.org/W2104908670","https://openalex.org/W2105571100","https://openalex.org/W2106665120","https://openalex.org/W2116183942","https://openalex.org/W2124614845","https://openalex.org/W2124621255","https://openalex.org/W2143001307","https://openalex.org/W2148043102","https://openalex.org/W2150740687","https://openalex.org/W2321629422"],"related_works":["https://openalex.org/W7099147426","https://openalex.org/W2396903920","https://openalex.org/W2040115680","https://openalex.org/W1985762385","https://openalex.org/W2007093903","https://openalex.org/W2320366601","https://openalex.org/W2411795273","https://openalex.org/W2407759023","https://openalex.org/W2526226937","https://openalex.org/W2042300239"],"abstract_inverted_index":{"Despite":[0],"the":[1,21,32,40],"potential":[2],"importance":[3],"of":[4,29],"senescence":[5,43],"in":[6,20],"tumour":[7],"suppression,":[8],"its":[9],"effector":[10],"mechanism":[11],"is":[12],"poorly":[13],"understood.":[14],"Recent":[15],"studies":[16],"suggest":[17],"that":[18],"alterations":[19],"chromatin":[22,45],"environment":[23],"might":[24],"add":[25],"an":[26],"additional":[27],"layer":[28],"stability":[30],"to":[31],"phenotype.":[33],"In":[34],"this":[35],"review,":[36],"recent":[37],"discoveries":[38],"on":[39],"interplay":[41],"between":[42],"and":[44],"biology":[46],"are":[47],"overviewed.":[48]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}