{"id":"https://openalex.org/W2069698304","doi":"https://doi.org/10.1186/1750-1326-5-56","title":"ER stress response plays an important role in aggregation of \u03b1-synuclein","display_name":"ER stress response plays an important role in aggregation of \u03b1-synuclein","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2069698304","doi":"https://doi.org/10.1186/1750-1326-5-56","mag":"2069698304","pmid":"https://pubmed.ncbi.nlm.nih.gov/21144044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3016345"},"language":"en","primary_location":{"id":"doi:10.1186/1750-1326-5-56","doi":"https://doi.org/10.1186/1750-1326-5-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-5-56","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-5-56","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-5-56","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076140355","display_name":"Peizhou Jiang","orcid":"https://orcid.org/0000-0002-3761-3068","observed_orcids":["https://orcid.org/0000-0002-3761-3068"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peizhou Jiang","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. Yen.shu-hui@mayo.edu","Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. Yen.shu-hui@mayo.edu","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113446345","display_name":"Ming Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Gan","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019999054","display_name":"Abdul Shukkur Ebrahim","orcid":"https://orcid.org/0000-0003-4483-4966","observed_orcids":["https://orcid.org/0000-0003-4483-4966"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Shukkur Ebrahim","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108454197","display_name":"Wen-Lang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Lang Lin","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071498766","display_name":"Heather L. Melrose","orcid":"https://orcid.org/0000-0001-9663-7652","observed_orcids":["https://orcid.org/0000-0001-9663-7652"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather L Melrose","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113622624","display_name":"Shu-Hui C. Yen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shu-Hui C Yen","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","Department of Neuroscience, Mayo Clinic, Jacksonville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic, Jacksonville, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113622624"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":3.6265,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.92820613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"56","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/er-stress-response","display_name":"ER stress response","score":0.8270000219345093},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/salubrinal","display_name":"salubrinal","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.6589999794960022},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7411829233169556},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5209140181541443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.490075945854187},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4717743396759033},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4646539092063904},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.4494936466217041},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43075454235076904},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.42953455448150635},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.40742596983909607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3386343717575073},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.2737264037132263},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.21375229954719543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19857409596443176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19295960664749146},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.15512454509735107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11938077211380005},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09788811206817627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1750-1326-5-56","doi":"https://doi.org/10.1186/1750-1326-5-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-5-56","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-5-56","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3016345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3016345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Neurodegener","raw_type":"Text"},{"id":"pmid:21144044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21144044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3e2dc3be29b84ea8a96843032166607d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3e2dc3be29b84ea8a96843032166607d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Neurodegeneration, Vol 5, Iss 1, p 56 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1750-1326-5-56","doi":"https://doi.org/10.1186/1750-1326-5-56","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-5-56","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-5-56","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069698304.pdf","grobid_xml":"https://content.openalex.org/works/W2069698304.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1531585137","https://openalex.org/W1965514223","https://openalex.org/W1965778124","https://openalex.org/W1968112541","https://openalex.org/W1974112332","https://openalex.org/W1978989017","https://openalex.org/W1981701640","https://openalex.org/W1983187777","https://openalex.org/W1987249631","https://openalex.org/W1992902970","https://openalex.org/W1994956698","https://openalex.org/W1995184566","https://openalex.org/W1997604339","https://openalex.org/W1997849090","https://openalex.org/W2001025550","https://openalex.org/W2010612415","https://openalex.org/W2012968783","https://openalex.org/W2013919679","https://openalex.org/W2027181683","https://openalex.org/W2033483604","https://openalex.org/W2035879579","https://openalex.org/W2036388828","https://openalex.org/W2037460022","https://openalex.org/W2037574006","https://openalex.org/W2037809197","https://openalex.org/W2040462263","https://openalex.org/W2043591723","https://openalex.org/W2044550125","https://openalex.org/W2053875358","https://openalex.org/W2058793855","https://openalex.org/W2060165207","https://openalex.org/W2060287185","https://openalex.org/W2064080881","https://openalex.org/W2071243806","https://openalex.org/W2073601762","https://openalex.org/W2073825819","https://openalex.org/W2077398422","https://openalex.org/W2078364998","https://openalex.org/W2084727378","https://openalex.org/W2087036363","https://openalex.org/W2091204354","https://openalex.org/W2091265794","https://openalex.org/W2095619100","https://openalex.org/W2096083625","https://openalex.org/W2098132374","https://openalex.org/W2107733280","https://openalex.org/W2114835861","https://openalex.org/W2123431154","https://openalex.org/W2123575108","https://openalex.org/W2125334861","https://openalex.org/W2126613337","https://openalex.org/W2134024590","https://openalex.org/W2134272142","https://openalex.org/W2139386840","https://openalex.org/W2140487984","https://openalex.org/W2150656456","https://openalex.org/W2152693222","https://openalex.org/W2154737306","https://openalex.org/W2158930854","https://openalex.org/W2167678675","https://openalex.org/W2169049494","https://openalex.org/W2171348543","https://openalex.org/W2171690812","https://openalex.org/W2171914962"],"related_works":["https://openalex.org/W2135178483","https://openalex.org/W3134059217","https://openalex.org/W1992241406","https://openalex.org/W2093639551","https://openalex.org/W2095619100","https://openalex.org/W2043591723","https://openalex.org/W7138842160","https://openalex.org/W2038110903","https://openalex.org/W4385428609","https://openalex.org/W2024919859"],"abstract_inverted_index":{"BACKGROUND:":[0],"Accumulation":[1],"of":[2,11,51,62,208,226,234],"filamentous":[3],"\u03b1-synuclein":[4,20,40,68,87,115,147,198,210],"as":[5,122,124],"Lewy":[6,52],"bodies":[7],"is":[8],"a":[9,31,186],"hallmark":[10],"Parkinson's":[12],"disease.":[13],"To":[14],"identify":[15],"the":[16,25,55,60,96,232],"mechanisms":[17],"involved":[18],"in":[19,70,162],"assembly":[21],"and":[22,41,48,73,104,112,120,149,216],"determine":[23],"whether":[24],"assemblies":[26],"are":[27],"cytotoxic,":[28],"we":[29,58],"developed":[30],"cell":[32],"model":[33],"(3D5)":[34],"that":[35,44,205],"inducibly":[36],"expresses":[37],"wild-type":[38,209],"human":[39],"forms":[42],"inclusions":[43],"reproduce":[45],"many":[46],"morphological":[47],"biochemical":[49],"characteristics":[50],"bodies.":[53],"In":[54,182],"present":[56],"study,":[57],"evaluated":[59],"effects":[61,159,171],"several":[63],"histone":[64],"deacetylase":[65],"inhibitors":[66],"on":[67],"aggregation":[69,233],"3D5":[71,102],"cells":[72,84,103,191,218],"primary":[74,105,136],"neuronal":[75],"cultures.":[76,106],"These":[77,170],"drugs":[78],"have":[79],"been":[80],"demonstrated":[81,161],"to":[82,93,219],"protect":[83],"transiently":[85],"overexpressing":[86,141],"from":[88,138,192],"its":[89],"toxicity.":[90],"RESULTS:":[91],"Contrary":[92],"transient":[94],"transfectants,":[95],"drug":[97],"treatment":[98],"did":[99,195],"not":[100,196],"benefit":[101],"The":[107,131],"treated":[108,164],"were":[109,160,172],"less":[110],"viable":[111],"contained":[113],"more":[114,146],"oligomers,":[116],"active":[117],"caspases":[118],"3":[119],"9,":[121],"well":[123],"ER":[125,150,168,179,213,227],"stress":[126,151,180,214,228],"markers":[127,152],"than":[128,153],"non-treated":[129],"counterparts.":[130,157],"drug-treated,":[132],"induced-3D5":[133],"cells,":[134],"or":[135,155],"cultures":[137,163],"transgenic":[139],"mice":[140],"(<2":[142],"fold)":[143],"\u03b1-synuclein,":[144],"displayed":[145],"oligomers":[148],"non-induced":[154],"non-transgenic":[156],"Similar":[158],"with":[165,176,185],"tunicamycin,":[166],"an":[167,178,206,224],"stressor.":[169],"blocked":[173],"by":[174],"co-treatment":[175,184],"salubrinal,":[177],"inhibitor.":[181],"comparison,":[183],"pan":[187],"caspase":[188],"inhibitor":[189],"protected":[190],"demise":[193],"but":[194],"reduce":[197],"oligomer":[199],"accumulation.":[200],"CONCLUSIONS:":[201],"Our":[202],"results":[203],"indicate":[204],"increase":[207,225],"can":[211,230],"elicit":[212],"response":[215,229],"sensitize":[217],"further":[220],"insults.":[221],"Most":[222],"importantly,":[223],"promote":[231],"wild":[235],"type":[236],"\u03b1-synuclein.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
