{"id":"https://openalex.org/W2069675520","doi":"https://doi.org/10.1249/00005768-200405001-00962","title":"Chronic Sodium Bicarbonate Ingestion Affects Training Adaptations during Severe Exercise Training","display_name":"Chronic Sodium Bicarbonate Ingestion Affects Training Adaptations during Severe Exercise Training","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2069675520","doi":"https://doi.org/10.1249/00005768-200405001-00962","mag":"2069675520"},"language":"en","primary_location":{"id":"doi:10.1249/00005768-200405001-00962","doi":"https://doi.org/10.1249/00005768-200405001-00962","is_oa":false,"landing_page_url":"https://doi.org/10.1249/00005768-200405001-00962","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027068796","display_name":"Johann Edge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Johann Edge","raw_affiliation_strings":["The University of Western Australia, Perth, Australia","(Sponsor: Alan Morton, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"(Sponsor: Alan Morton, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056757124","display_name":"David John Bishop","orcid":"https://orcid.org/0000-0002-6956-9188","observed_orcids":["https://orcid.org/0000-0002-6956-9188"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Bishop","raw_affiliation_strings":["The University of Western Australia, Perth, Australia","(Sponsor: Alan Morton, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"(Sponsor: Alan Morton, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065596504","display_name":"Carm\u00e9l Goodman","orcid":"https://orcid.org/0000-0002-1571-9486","observed_orcids":["https://orcid.org/0000-0002-1571-9486"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carmel Goodman","raw_affiliation_strings":["The University of Western Australia, Perth, Australia","(Sponsor: Alan Morton, FACSM)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"(Sponsor: Alan Morton, FACSM)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177877127"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"Supplement","first_page":"S201","last_page":"S201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-bicarbonate-ingestion","display_name":"sodium bicarbonate ingestion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metabolic-alkalosis","display_name":"metabolic alkalosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/training-adaptation","display_name":"training effects","score":0.6269999742507935},{"id":"https://openalex.org/keywords/high-intensity-interval-training","display_name":"high-intensity interval training","score":0.847000002861023},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lactate-threshold","display_name":"lactate threshold","score":0.9269999861717224},{"id":"https://openalex.org/keywords/peak-oxygen-uptake","display_name":"peak oxygen uptake","score":0.8389999866485596},{"id":"https://openalex.org/keywords/muscle-lactate","display_name":"muscle lactate","score":0.609000027179718},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/muscle-metabolites","display_name":"muscle metabolites","score":0.6140000224113464},{"id":"https://openalex.org/keywords/female-athletes","display_name":"female athletes","score":0.609000027179718},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.4309999942779541},{"id":"https://openalex.org/keywords/hydrogen-ion-accumulation","display_name":"hydrogen ion accumulation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/chronic-supplementation","display_name":"chronic supplementation","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.8139729499816895},{"id":"https://openalex.org/C2776420369","wikidata":"https://www.wikidata.org/wiki/Q179731","display_name":"Sodium bicarbonate","level":2,"score":0.6743072867393494},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6369990110397339},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6256487369537354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5735463500022888},{"id":"https://openalex.org/C2992361435","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"Aerobic capacity","level":2,"score":0.55711430311203},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.5408523678779602},{"id":"https://openalex.org/C2776294035","wikidata":"https://www.wikidata.org/wiki/Q3480702","display_name":"Lactate threshold","level":5,"score":0.4916420578956604},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.488324373960495},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.40433448553085327},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.37960028648376465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3720773458480835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26220226287841797},{"id":"https://openalex.org/C2992422156","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Blood lactate","level":4,"score":0.2566760778427124},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2543427348136902},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1257912814617157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.111029714345932},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1249/00005768-200405001-00962","doi":"https://doi.org/10.1249/00005768-200405001-00962","is_oa":false,"landing_page_url":"https://doi.org/10.1249/00005768-200405001-00962","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},{"id":"doi:10.1097/00005768-200405001-00962","doi":"https://doi.org/10.1097/00005768-200405001-00962","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005768-200405001-00962","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066026113","https://openalex.org/W2007237261","https://openalex.org/W2088768576","https://openalex.org/W77907264","https://openalex.org/W2027748559","https://openalex.org/W1969302255","https://openalex.org/W2524259421","https://openalex.org/W3016890667","https://openalex.org/W3008075516","https://openalex.org/W2054182712"],"abstract_inverted_index":{"1410":[0],"PURPOSE:":[1],"The":[2],"purpose":[3],"of":[4,12,44,91,113,124,256,287,312,340],"this":[5,40],"study":[6],"was":[7,232],"to":[8,49,85,111,146,331,350],"determine":[9,50,86],"the":[10,83,101,121,128,136,176,182,190,262,265,269,284,303,335],"effects":[11],"sodium":[13],"bicarbonate":[14],"ingestion":[15],"(NaHCO3)":[16],"during":[17,175,261,289,343],"training,":[18,292,334],"on":[19,107],"changes":[20,237],"in":[21,39,193,212,238,326],"severe":[22],"intensity":[23],"exercise":[24,47,62,291,333],"tolerance":[25,63,311],"and":[26,28,52,81,93,109,178,200,216,246,251,281,298],"aerobic":[27,297],"anaerobic":[29,89,254,299],"capacity.":[30],"METHODS:":[31],"Sixteen":[32],"active,":[33],"but":[34],"not":[35,227],"well-trained":[36],"females":[37],"participated":[38],"study.":[41],"Tests":[42],"consisted":[43],"a":[45,140,233,252,308],"graded":[46],"test":[48,64],"VO2peak":[51,71,217],"lactate":[53,240],"threshold":[54],"(LT)":[55],"followed":[56],"\u223c48":[57],"h":[58],"later":[59],"by":[60,264],"an":[61],"(ET;":[65],"total":[66,125,172,194],"work":[67,173,195],"completed":[68,174],"at":[69],"pre-training":[70],"intensity).":[72],"Muscle":[73],"biopsies":[74],"(Vastus":[75],"lateralis)":[76],"were":[77,103],"taken":[78],"immediately":[79],"before":[80],"after":[82],"ET":[84,177,263],"muscle":[87,94,239],"metabolites,":[88],"yield":[90,255],"ATP":[92,257],"buffer":[95],"capacity":[96],"(\u03b2min-vitro).":[97],"After":[98],"initial":[99],"testing":[100],"subjects":[102,327],"randomly":[104],"assigned":[105],"(matched":[106],"LT":[108,179,201],"ET)":[110],"one":[112],"two":[114],"training":[115,148,230,316,344],"groups.":[116,225,321],"Each":[117],"matched":[118,319],"pair":[119],"performed":[120],"same":[122],"amount":[123],"work,":[126],"however":[127],"experimental":[129],"group":[130,138,184,192,267,305],"ingested":[131,139],"NaHCO3,":[132],"(0.4":[133],"g\u00b7kg\u22121)":[134,144],"while":[135],"control":[137],"placebo":[141],"(NaCl,":[142],"0.2":[143],"prior":[145],"each":[147],"session.":[149],"Training":[150],"involved":[151],"6\u201312,":[152],"2-min":[153],"high-intensity":[154],"intervals":[155],"(140\u2013180%":[156],"LT;":[157],"1":[158],"min":[159],"rest),":[160],"3":[161],"\u00d7":[162],"wk":[163],"for":[164,235],"8":[165],"weeks.":[166],"RESULTS:":[167],"Both":[168,206],"groups":[169,207],"significantly":[170,186,309],"increased":[171],"(P<0.05).":[180],"However,":[181],"NaHCO3":[183,266,304],"had":[185,209,307],"greater":[187,236,310],"improvements":[188,211],"than":[189,268],"NaCl":[191,270],"(160%":[196],"v":[197,203],"126%;":[198],"P<0.05)":[199,215],"(26%":[202],"15%;":[204],"P<0.05).":[205],"also":[208,306],"significant":[210,222],"\u03b2m":[213],"in-vitro(\u223c10%;":[214],"(\u223c20%;":[218],"P<0.05),":[219],"with":[220],"no":[221],"differences":[223],"between":[224,320],"While":[226],"significant,":[228],"post":[229],"there":[231],"tendency":[234],"(Effect":[241],"size":[242],"[ES]":[243],"=":[244,249,259],"1.4)":[245],"PCr":[247],"(ES":[248,258],"0.54)":[250],"higher":[253],"1.2)":[260],"group.":[271],"CONCLUSIONS:":[272],"We":[273],"have":[274],"shown":[275],"that":[276,325],"chronically":[277],"inducing":[278],"metabolic":[279],"alkalosis":[280],"thereby":[282],"altering":[283],"likely":[285],"accumulation":[286,336],"H+":[288],"severe-intensity":[290,313,332],"may":[293,345],"beneficially":[294],"affect":[295,346],"both":[296],"fitness":[300],"adaptations.":[301],"Post-training,":[302],"exercise,":[314],"despite":[315],"workloads":[317],"being":[318],"These":[322],"results":[323],"suggest":[324],"who":[328],"are":[329],"unaccustomed":[330],"or":[337],"removal":[338],"rate":[339],"hydrogen":[341],"ions":[342],"some":[347],"intracellular":[348],"adaptations":[349],"highintensity":[351],"exercise.":[352]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}