{"id":"https://openalex.org/W206959108","doi":null,"title":"Biomarkers of exercise-induced myocardial stress in relation to inflammatory and oxidative stress.","display_name":"Biomarkers of exercise-induced myocardial stress in relation to inflammatory and oxidative stress.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W206959108","mag":"206959108","pmid":"https://pubmed.ncbi.nlm.nih.gov/18198658"},"language":"en","primary_location":{"id":"pmid:18198658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18198658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047651473","display_name":"Daniel K\u00f6nig","orcid":"https://orcid.org/0000-0002-4104-4013","observed_orcids":["https://orcid.org/0000-0002-4104-4013"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel K\u00f6nig","raw_affiliation_strings":["Centre for Internal Medicine, Division of Rehabilitation, Prevention and Sports Medicine, Freiburg University Hospital, Hugstetterstr. 55, 79106 Freiburg, Germany. Daniel.Koenig@uniklinik-freiburg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Internal Medicine, Division of Rehabilitation, Prevention and Sports Medicine, Freiburg University Hospital, Hugstetterstr. 55, 79106 Freiburg, Germany. Daniel.Koenig@uniklinik-freiburg.de","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042697818","display_name":"Oliver Neubauer","orcid":"https://orcid.org/0000-0001-6835-8787","observed_orcids":["https://orcid.org/0000-0001-6835-8787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Neubauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078486787","display_name":"Lukas Nics","orcid":"https://orcid.org/0000-0002-1034-876X","observed_orcids":["https://orcid.org/0000-0002-1034-876X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Nics","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047584122","display_name":"Norbert Kern","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Kern","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007565734","display_name":"Aloys Berg","orcid":"https://orcid.org/0000-0002-6794-9494","observed_orcids":["https://orcid.org/0000-0002-6794-9494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aloys Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111430894","display_name":"Emmanuel Biss\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanuel Bisse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101760386","display_name":"Karl\u2010Heinz Wagner","orcid":"https://orcid.org/0000-0002-1683-7265","observed_orcids":["https://orcid.org/0000-0002-1683-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl-Heinz Wagner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2318,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.882788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":null,"first_page":"15","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-troponin-t","display_name":"cardiac troponin T","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9860000014305115},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.8799999952316284},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-vitamins","display_name":"antioxidant vitamins","score":0.8299999833106995},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.8529999852180481},{"id":"https://openalex.org/keywords/triathletes","display_name":"triathletes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ironman-triathlon","display_name":"Ironman triathlon","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.6460000276565552},{"id":"https://openalex.org/keywords/heterophile-antibodies","display_name":"heterophile antibodies","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7918978929519653},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7643659114837646},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.756081223487854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6412756443023682},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6331444978713989},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5663991570472717},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.5119022130966187},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.47864022850990295},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.4558708369731903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42998161911964417},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4271154999732971},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3118382692337036},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.11845433712005615}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014336","descriptor_name":"Troponin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18198658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18198658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exercise immunology review","raw_type":"Journal Article"},{"id":"pmh:info:fedora/oai:univie.ac.at:o:243616","doi":null,"is_oa":false,"landing_page_url":"https://phaidra.univie.ac.at/o:243616","pdf_url":null,"source":{"id":"https://openalex.org/S4306401993","display_name":"Phaidra (Universit\u00e4t Wien)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129774422","host_organization_name":"University of Vienna","host_organization_lineage":["https://openalex.org/I129774422"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:1077-5552","raw_type":"article"},{"id":"mag:206959108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18198658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W9187580","https://openalex.org/W100564515","https://openalex.org/W185502132","https://openalex.org/W203997029","https://openalex.org/W1788477850","https://openalex.org/W1817200870","https://openalex.org/W1905809524","https://openalex.org/W1914273756","https://openalex.org/W1941698222","https://openalex.org/W1967239730","https://openalex.org/W1969294506","https://openalex.org/W1969658971","https://openalex.org/W1972770489","https://openalex.org/W1974603470","https://openalex.org/W1975612476","https://openalex.org/W1977986459","https://openalex.org/W1982405566","https://openalex.org/W1983613546","https://openalex.org/W1986336960","https://openalex.org/W1987089161","https://openalex.org/W1988816170","https://openalex.org/W1996854958","https://openalex.org/W1997820349","https://openalex.org/W2001742013","https://openalex.org/W2002916905","https://openalex.org/W2003624364","https://openalex.org/W2008574075","https://openalex.org/W2010672422","https://openalex.org/W2018213955","https://openalex.org/W2019764408","https://openalex.org/W2021859237","https://openalex.org/W2028971149","https://openalex.org/W2028977365","https://openalex.org/W2034052955","https://openalex.org/W2034465514","https://openalex.org/W2037799674","https://openalex.org/W2039529032","https://openalex.org/W2043927094","https://openalex.org/W2051495558","https://openalex.org/W2051686997","https://openalex.org/W2053743696","https://openalex.org/W2054911104","https://openalex.org/W2060396823","https://openalex.org/W2063922050","https://openalex.org/W2064588058","https://openalex.org/W2068514742","https://openalex.org/W2074196229","https://openalex.org/W2074276869","https://openalex.org/W2077669038","https://openalex.org/W2083627241","https://openalex.org/W2084559990","https://openalex.org/W2085832118","https://openalex.org/W2086325224","https://openalex.org/W2090699823","https://openalex.org/W2093215533","https://openalex.org/W2094122563","https://openalex.org/W2098655842","https://openalex.org/W2109348687","https://openalex.org/W2114089832","https://openalex.org/W2114280375","https://openalex.org/W2116223650","https://openalex.org/W2118342937","https://openalex.org/W2121202741","https://openalex.org/W2122563040","https://openalex.org/W2131258582","https://openalex.org/W2131493413","https://openalex.org/W2133272765","https://openalex.org/W2136109573","https://openalex.org/W2137186024","https://openalex.org/W2142108969","https://openalex.org/W2152555940","https://openalex.org/W2156047313","https://openalex.org/W2156325087","https://openalex.org/W2160851001","https://openalex.org/W2162210935","https://openalex.org/W2165218249","https://openalex.org/W2166809238","https://openalex.org/W2167313423","https://openalex.org/W2168626108","https://openalex.org/W2171109885","https://openalex.org/W2172133801","https://openalex.org/W2288490959","https://openalex.org/W2290287568","https://openalex.org/W2403420725","https://openalex.org/W2413694950","https://openalex.org/W2417075758"],"related_works":["https://openalex.org/W2034073742","https://openalex.org/W2526582085","https://openalex.org/W2160851001","https://openalex.org/W1970487529","https://openalex.org/W2793167579","https://openalex.org/W337615608","https://openalex.org/W2051495558","https://openalex.org/W2087517788","https://openalex.org/W2470636997","https://openalex.org/W2352139645"],"abstract_inverted_index":{"Increased":[0],"concentrations":[1,41],"of":[2,38,66,81,115,137],"biomarkers":[3],"reflecting":[4],"myocardial":[5,48,166],"stress":[6,74,103,141,167],"such":[7],"as":[8],"cardiac":[9,126],"troponin":[10,54,127],"I":[11],"and":[12,14,35,83,129,155],"T":[13,128],"brain":[15],"natriuretic":[16],"peptide":[17],"(BNP)":[18],"have":[19],"been":[20],"observed":[21,85],"following":[22,117,169],"strenuous,":[23],"long-lasting":[24],"endurance":[25,171],"exercise.":[26],"The":[27],"pathophysiological":[28],"mechanisms":[29],"are":[30],"still":[31],"not":[32,132],"fully":[33],"elucidated":[34],"the":[36,79,97,122,160],"interpretations":[37],"increased":[39],"post-exercise":[40],"range":[42],"from":[43],"(i)":[44],"evidence":[45,67],"for":[46,107,163],"exercise-induced":[47,108,138],"damage":[49],"to":[50,158],"(ii)":[51],"non-relevant":[52],"spurious":[53],"elevations,":[55],"presumably":[56],"caused":[57],"by":[58],"assay":[59],"imprecision":[60],"or":[61,72,92,101,142],"heterophilic":[62],"antibodies.":[63],"Several":[64],"lines":[65],"suggest":[68],"that":[69,99],"inflammatory":[70,100,153],"processes":[71],"oxidative":[73,102,140],"could":[75],"be":[76],"involved":[77],"in":[78,86,111,125,165],"rise":[80],"NT-proBNP":[82,130],"Troponin":[84],"critically":[87],"ill":[88],"patients":[89],"with":[90,134,151],"sepsis":[91],"burn":[93],"injury.":[94],"We":[95],"tested":[96],"hypothesis":[98],"is":[104],"also":[105],"responsible":[106],"cardiomyocyte":[109],"strain":[110],"a":[112],"large":[113],"cohort":[114],"triathletes":[116],"an":[118],"Ironman":[119],"triathlon.":[120],"However,":[121],"post-race":[123],"increase":[124],"was":[131],"associated":[133],"several":[135],"markers":[136,154,168],"inflammation,":[139],"antioxidant":[143],"vitamins.":[144],"Therefore,":[145],"we":[146],"clearly":[147],"need":[148],"more":[149],"studies":[150],"other":[152],"different":[156],"designs":[157],"elucidate":[159],"scientific":[161],"background":[162],"increases":[164],"strenuous":[170],"events.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}