{"id":"https://openalex.org/W2069496935","doi":"https://doi.org/10.1155/2013/493019","title":"New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity","display_name":"New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2069496935","doi":"https://doi.org/10.1155/2013/493019","mag":"2069496935","pmid":"https://pubmed.ncbi.nlm.nih.gov/24232670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3819829"},"language":"en","primary_location":{"id":"doi:10.1155/2013/493019","doi":"https://doi.org/10.1155/2013/493019","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/493019","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/493019.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/bmri/2013/493019.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002316061","display_name":"Guanglong Jiang","orcid":"https://orcid.org/0000-0002-9233-052X","observed_orcids":["https://orcid.org/0000-0002-9233-052X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanglong Jiang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":"https://orcid.org/0000-0002-9233-052X","affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054990105","display_name":"Arindom Chakraborty","orcid":"https://orcid.org/0000-0003-0741-8955","observed_orcids":["https://orcid.org/0000-0003-0741-8955","https://orcid.org/0000-0002-2207-8656"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arindom Chakraborty","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":"https://orcid.org/0000-0002-2207-8656","affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060338311","display_name":"Zhiping Paul Wang","orcid":"https://orcid.org/0000-0002-3796-3164","observed_orcids":["https://orcid.org/0000-0002-3796-3164"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiping Wang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019055956","display_name":"Malaz A. Boustani","orcid":"https://orcid.org/0000-0003-0330-677X","observed_orcids":["https://orcid.org/0000-0003-0330-677X"]},"institutions":[{"id":"https://openalex.org/I1324682000","display_name":"Regenstrief Institute","ror":"https://ror.org/05f2ywb48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1324682000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malaz Boustani","raw_affiliation_strings":["Regenstrief Institute, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenstrief Institute, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I1324682000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337355","display_name":"Yunlong Liu","orcid":"https://orcid.org/0000-0002-2699-626X","observed_orcids":["https://orcid.org/0000-0002-2699-626X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunlong Liu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014194365","display_name":"Todd C. Skaar","orcid":"https://orcid.org/0000-0002-3849-374X","observed_orcids":["https://orcid.org/0000-0002-3849-374X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Skaar","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100383618","display_name":"Lang Li","orcid":"https://orcid.org/0000-0002-0746-1809","observed_orcids":["https://orcid.org/0000-0002-0746-1809","https://orcid.org/0000-0002-5334-8719","https://orcid.org/0000-0002-4528-3927"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lang Li","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100383618"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":1.4396,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82669644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/trans-eqtl","display_name":"trans-eQTL","score":0.6710000038146973},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6510000228881836},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.6209999918937683},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.39100000262260437},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.7311185598373413},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7216223478317261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6138958930969238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5552399754524231},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.5465863943099976},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5464025139808655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49252137541770935},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.4526219367980957},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4510400593280792},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4404337704181671},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.41318416595458984},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32244911789894104},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18179866671562195}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1155/2013/493019","doi":"https://doi.org/10.1155/2013/493019","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/493019","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/493019.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2812906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3819829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3819829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3819829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Res Int","raw_type":"Text"},{"id":"pmid:24232670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24232670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed research international","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8606cc4e7970421491e41c84fb4db929","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8606cc4e7970421491e41c84fb4db929","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Research International, Vol 2013 (2013)","raw_type":"article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/47492","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/47492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1155/2013/493019","doi":"https://doi.org/10.1155/2013/493019","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/493019","pdf_url":"https://downloads.hindawi.com/journals/bmri/2013/493019.pdf","source":{"id":"https://openalex.org/S1010394304","display_name":"BioMed Research International","issn_l":"1110-7243","issn":["1110-7243","1110-7251","2314-6133","2314-6141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","medline","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMed Research International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1325993933","display_name":null,"funder_award_id":"R01HS019818-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2043904495","display_name":null,"funder_award_id":"R01HS019818-01","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G5772008974","display_name":"Regulation of drug metabolizing enzymes by miRNAs","funder_award_id":"R01GM088076","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5875709954","display_name":"INDIANA PROSPECT","funder_award_id":"R01HS019818","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G7439202828","display_name":null,"funder_award_id":"R01 GM088076","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G7763293017","display_name":null,"funder_award_id":"R01 GM74217","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G845393132","display_name":"Bayesian Tools for PBPK Models in Drug Interaction Research","funder_award_id":"R01GM074217","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069496935.pdf","grobid_xml":"https://content.openalex.org/works/W2069496935.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1598156054","https://openalex.org/W1969296365","https://openalex.org/W1971440513","https://openalex.org/W1976876708","https://openalex.org/W2003775235","https://openalex.org/W2021151787","https://openalex.org/W2040912377","https://openalex.org/W2048868021","https://openalex.org/W2059742736","https://openalex.org/W2067551453","https://openalex.org/W2074199852","https://openalex.org/W2084708009","https://openalex.org/W2086799994","https://openalex.org/W2094248448","https://openalex.org/W2104465908","https://openalex.org/W2114613623","https://openalex.org/W2117007075","https://openalex.org/W2118308505","https://openalex.org/W2123443995","https://openalex.org/W2127336501","https://openalex.org/W2136078375","https://openalex.org/W2136940727","https://openalex.org/W2140817897","https://openalex.org/W2142260323","https://openalex.org/W2142814345","https://openalex.org/W2145090915","https://openalex.org/W2152905639","https://openalex.org/W2154998360","https://openalex.org/W4212838134"],"related_works":["https://openalex.org/W2924843739","https://openalex.org/W2592591401","https://openalex.org/W4389132632","https://openalex.org/W2949244245","https://openalex.org/W2129758889","https://openalex.org/W6967391537","https://openalex.org/W3170225570","https://openalex.org/W2925762110","https://openalex.org/W2581246226","https://openalex.org/W2147469491"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,110],"genome-wide":[2],"association":[3],"studies":[4],"(GWAS)":[5],"have":[6],"been":[7],"successful":[8],"during":[9],"the":[10,19,22,41,125,159,163,178,186,191],"last":[11],"few":[12],"years.":[13],"A":[14,116],"key":[15],"challenge":[16],"is":[17,24,172],"that":[18],"interpretation":[20],"of":[21,32,112,127,165,185],"results":[23],"not":[25],"straightforward,":[26],"especially":[27],"for":[28,100,190],"transacting":[29],"SNPs.":[30],"Integration":[31],"transcriptome":[33],"data":[34],"into":[35],"GWAS":[36],"may":[37],"provide":[38],"clues":[39],"elucidating":[40],"mechanisms":[42],"by":[43,72,130],"which":[44,138],"a":[45,50,56,173],"genetic":[46,188],"variant":[47],"leads":[48,119],"to":[49,61,120,149,162],"disease.":[51],"METHODS:":[52],"Here,":[53],"we":[54],"developed":[55],"novel":[57],"mediation":[58,170],"analysis":[59,171],"approach":[60,175],"identify":[62],"new":[63],"expression":[64,126],"quantitative":[65],"trait":[66],"loci":[67],"(eQTL)":[68],"driving":[69],"CYP2D6":[70],"activity":[71,79,86],"combining":[73],"genotype,":[74],"gene":[75],"expression,":[76],"and":[77,83,98,107,146,151],"enzyme":[78],"data.":[80],"RESULTS:":[81],"389,573":[82],"1,214,416":[84],"SNP-transcript-CYP2D6":[85],"trios":[87],"are":[88,114],"found":[89],"strongly":[90],"associated":[91],"(P":[92],"<":[93],"10\u207b\u2075,":[94],"FDR":[95],"=":[96],"16.6%":[97],"11.7%)":[99],"two":[101],"different":[102],"genotype":[103],"platforms,":[104],"namely,":[105],"Affymetrix":[106],"Illumina,":[108],"respectively.":[109],"majority":[111],"eQTLs":[113],"trans-SNPs.":[115],"single":[117],"polymorphism":[118],"widespread":[121],"downstream":[122],"changes":[123],"in":[124,176],"distant":[128],"genes":[129],"affecting":[131],"major":[132],"regulators":[133],"or":[134],"transcription":[135],"factors":[136],"(TFs),":[137],"would":[139],"be":[140],"visible":[141],"as":[142],"an":[143],"eQTL":[144,156],"hotspot":[145],"can":[147],"lead":[148,161],"large":[150],"consistent":[152],"biological":[153],"effects.":[154],"Overlapped":[155],"hotspots":[157],"with":[158],"mediators":[160],"discovery":[164],"64":[166],"TFs.":[167],"CONCLUSIONS:":[168],"Our":[169],"powerful":[174],"identifying":[177],"trans-QTL-phenotype":[179],"associations.":[180],"It":[181],"improves":[182],"our":[183],"understanding":[184],"functional":[187],"variations":[189],"liver":[192],"metabolism":[193],"mechanisms.":[194]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}