{"id":"https://openalex.org/W2069340882","doi":"https://doi.org/10.1002/hep.1840070616","title":"Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: Ultrastructure and integrity of the blood-brain barrier","display_name":"Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: Ultrastructure and integrity of the blood-brain barrier","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2069340882","doi":"https://doi.org/10.1002/hep.1840070616","mag":"2069340882","pmid":"https://pubmed.ncbi.nlm.nih.gov/3679092"},"language":"en","primary_location":{"id":"doi:10.1002/hep.1840070616","doi":"https://doi.org/10.1002/hep.1840070616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840070616","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030568693","display_name":"Peter G. Traber","orcid":"https://orcid.org/0000-0002-5952-5720","observed_orcids":["https://orcid.org/0000-0002-5952-5720"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter G. Traber","raw_affiliation_strings":["Department of Medicine, Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611","Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109942916","display_name":"Mauro Dal Canto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mauro Dal Canto","raw_affiliation_strings":["Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103124999","display_name":"Daniel R. Ganger","orcid":"https://orcid.org/0000-0003-1114-4192","observed_orcids":["https://orcid.org/0000-0003-1114-4192"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Ganger","raw_affiliation_strings":["Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038845488","display_name":"Andr\u00e9s T. Blei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andres T. Blei","raw_affiliation_strings":["Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neuropathology, Lakeside Veterans Administration Medical Center and Northwestern University School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030568693","https://openalex.org/A5038845488"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1322918889","https://openalex.org/I2799886695"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":6.1714,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95814782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"1272","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.9810000061988831},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9520000219345093},{"id":"https://openalex.org/keywords/galactosamine","display_name":"galactosamine","score":0.7440000176429749},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7820000052452087},{"id":"https://openalex.org/keywords/astrocyte-swelling","display_name":"astrocyte swelling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hepatic-encephalopathy","display_name":"hepatic encephalopathy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/capillary-endothelial-cells","display_name":"capillary endothelial cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/brain-ultrastructure","display_name":"brain ultrastructure","score":0.8169999718666077},{"id":"https://openalex.org/keywords/water-accumulation","display_name":"water accumulation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7324924468994141},{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.7115446329116821},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.6386536955833435},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5249569416046143},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.5217153429985046},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.4627091884613037},{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.46166566014289856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45842400193214417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32750949263572693},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.25975704193115234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16885817050933838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15805324912071228},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.10868394374847412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08557209372520447},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005688","descriptor_name":"Galactosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.1840070616","doi":"https://doi.org/10.1002/hep.1840070616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840070616","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:3679092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3679092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8684369785","display_name":null,"funder_award_id":"2507 RR-5370","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W180086084","https://openalex.org/W190103538","https://openalex.org/W310193716","https://openalex.org/W1043684383","https://openalex.org/W1515404010","https://openalex.org/W1537701079","https://openalex.org/W1979002230","https://openalex.org/W2008390879","https://openalex.org/W2016703495","https://openalex.org/W2023222913","https://openalex.org/W2024578017","https://openalex.org/W2055626386","https://openalex.org/W2063441247","https://openalex.org/W2064514825","https://openalex.org/W2069802987","https://openalex.org/W2074857977","https://openalex.org/W2075833754","https://openalex.org/W2080281307","https://openalex.org/W2082212677","https://openalex.org/W2136138362","https://openalex.org/W2136413428","https://openalex.org/W2173273229","https://openalex.org/W2224712068","https://openalex.org/W2236358349","https://openalex.org/W2369189987","https://openalex.org/W2400867374","https://openalex.org/W2403921158","https://openalex.org/W2411332679","https://openalex.org/W2411392330","https://openalex.org/W2415069066","https://openalex.org/W4210637778","https://openalex.org/W4236074613","https://openalex.org/W4256240442","https://openalex.org/W4300710549","https://openalex.org/W4302476457","https://openalex.org/W6808243072"],"related_works":["https://openalex.org/W2411916501","https://openalex.org/W224682340","https://openalex.org/W2400867374","https://openalex.org/W2332093297","https://openalex.org/W2066134367","https://openalex.org/W1969248415","https://openalex.org/W2100835385","https://openalex.org/W2335736136","https://openalex.org/W2442145675","https://openalex.org/W2245313330"],"abstract_inverted_index":{"Brain":[0],"edema":[1,174],"is":[2,11,175],"a":[3,16],"major":[4],"complication":[5],"of":[6,19,27,33,51,58,66,95,98,108,115,131,147,172,182,188,191,198,206],"fulminant":[7,41],"hepatic":[8,42,60,207],"failure":[9,61],"and":[10,82,89,112,142],"responsible":[12],"for":[13],"death":[14],"in":[15,29,36,54,119,150,177,209],"large":[17,168],"percentage":[18],"patients.":[20],"We":[21,44],"previously":[22],"demonstrated":[23],"the":[24,34,37,47,52,55,63,93,109,127,132,157,162,185,189,204],"progressive":[25],"accumulation":[26,190],"water":[28],"grey":[30],"matter":[31,125],"areas":[32],"brain":[35,53,99,133,158,173],"rabbit":[38],"with":[39,79,180],"galactosamine-induced":[40],"failure.":[43],"now":[45],"report":[46],"electron":[48],"microscopic":[49],"morphology":[50],"same":[56],"model":[57],"acute":[59],"following":[62],"intravenous":[64],"injection":[65],"horseradish":[67,148],"peroxidase,":[68],"an":[69,74],"intravascular":[70],"tracer":[71],"which":[72],"forms":[73],"electron-dense":[75],"reaction":[76],"product.":[77],"Rabbits":[78],"both":[80],"mild":[81],"severe":[83],"encephalopathy":[84,208],"had":[85,134],"normal":[86,135],"blood":[87,90],"pressures":[88],"gases":[91],"at":[92],"time":[94],"study.":[96],"Fixation":[97],"tissue":[100],"was":[101,144,165],"obtained":[102],"by":[103],"whole-body":[104],"perfusion.":[105],"Marked":[106],"swelling":[107,181],"cytoplasm,":[110],"perineuronal":[111],"perivascular":[113],"processes":[114],"astrocytes":[116,183,195],"were":[117,140],"noted":[118],"cortical":[120],"gray,":[121],"but":[122],"not":[123],"white,":[124],"areas;":[126],"other":[128],"cellular":[129],"components":[130],"morphology.":[136],"Capillary":[137],"endothelial":[138,151],"cells":[139],"normal,":[141],"there":[143],"no":[145],"evidence":[146,171],"peroxidase":[149],"cell":[152],"vesicles,":[153],"basement":[154],"membranes":[155],"or":[156,196],"parenchyma,":[159],"suggesting":[160],"that":[161],"blood-brain":[163],"barrier":[164],"impermeable":[166],"to":[167,194,203],"molecules.":[169],"Histologic":[170],"seen":[176],"this":[178,210],"model,":[179],"as":[184],"primary":[186],"manifestation":[187],"water.":[192],"Damage":[193],"inhibition":[197],"their":[199],"function":[200],"may":[201],"contribute":[202],"pathogenesis":[205],"model.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}