{"id":"https://openalex.org/W2069340342","doi":"https://doi.org/10.3892/or.10.6.1753","title":"Selection criteria for high risk and low risk groups of recurrence and metastasis in patients with primary colorectal cancer","display_name":"Selection criteria for high risk and low risk groups of recurrence and metastasis in patients with primary colorectal cancer","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2069340342","doi":"https://doi.org/10.3892/or.10.6.1753","mag":"2069340342","pmid":"https://pubmed.ncbi.nlm.nih.gov/14534691"},"language":"en","primary_location":{"id":"doi:10.3892/or.10.6.1753","doi":"https://doi.org/10.3892/or.10.6.1753","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.10.6.1753","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012348080","display_name":"Masaya Mukai","orcid":"https://orcid.org/0000-0002-4931-0910","observed_orcids":["https://orcid.org/0000-0002-4931-0910"]},"institutions":[{"id":"https://openalex.org/I4210114625","display_name":"Shonan Oiso Hospital","ror":"https://ror.org/02dx51s73","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114625"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaya Mukai","raw_affiliation_strings":["Department of Surgery, Tokai University Oiso Hospital, Kanagawa 259-0198, Japan. colorectalmasaya@yahoo.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokai University Oiso Hospital, Kanagawa 259-0198, Japan. colorectalmasaya@yahoo.co.jp","institution_ids":["https://openalex.org/I4210114625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066165337","display_name":"Shinkichi Sato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinkichi Sato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tomomi Nishida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomomi Nishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058463619","display_name":"Nobukazu Komatsu","orcid":"https://orcid.org/0000-0002-6652-403X","observed_orcids":["https://orcid.org/0000-0002-6652-403X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobukazu Komatsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuaki Shiba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuaki Shiba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076728126","display_name":"Hisao Nakasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisao Nakasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110774302","display_name":"Hiroyasu Makuuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyasu Makuuchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6654,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.67611132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"10","issue":"6","first_page":"1753","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7170000076293945},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/high-risk-patient-identification","display_name":"high-risk patient identification","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cytokeratin-immunohistochemistry","display_name":"cytokeratin immunohistochemistry","score":0.925000011920929},{"id":"https://openalex.org/keywords/lymph-node-sinuses","display_name":"lymph node sinuses","score":0.7559999823570251},{"id":"https://openalex.org/keywords/venous-invasion","display_name":"venous invasion","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lymphatic-invasion","display_name":"lymphatic invasion","score":0.996999979019165},{"id":"https://openalex.org/keywords/dukes-classification","display_name":"Dukes classification","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tumor-invasion-depth","display_name":"depth of invasion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7228736877441406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6583235263824463},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6436344981193542},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6155056953430176},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.5636706948280334},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5299077033996582},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.4894901514053345},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47688227891921997},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4690221846103668},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.465949147939682},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4429278075695038},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.4398725926876068},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41439634561538696},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.33271491527557373},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27634769678115845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14798909425735474},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.12845569849014282},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.10.6.1753","doi":"https://doi.org/10.3892/or.10.6.1753","is_oa":false,"landing_page_url":"https://doi.org/10.3892/or.10.6.1753","pdf_url":null,"source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:14534691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14534691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4250161151","https://openalex.org/W7214212177","https://openalex.org/W1977113190","https://openalex.org/W2045918655","https://openalex.org/W2084425823","https://openalex.org/W1980197635","https://openalex.org/W4253868364","https://openalex.org/W2388049323","https://openalex.org/W2356610990","https://openalex.org/W2355808189"],"abstract_inverted_index":{"Among":[0],"371":[1],"patients":[2,8,66,78,95,181,203,216],"with":[3,173,197],"primary":[4],"colorectal":[5,223],"cancer,":[6],"54":[7],"suffered":[9],"from":[10],"recurrence/metastasis":[11,156],"(recurrence":[12],"group)":[13],"and":[14,35,93,127,134,146,164,168,179,192,219],"317":[15],"survived":[16],"without":[17],"recurrence":[18],"for":[19,63,75,90,109,155,176,200,214],"at":[20],"least":[21],"5":[22],"years":[23],"(non-recurrence":[24],"group).":[25],"The":[26,152],"clinicopathological":[27],"characteristics":[28],"of":[29,54,102,116,171,195,222],"the":[30,41,55,114,123,160,187],"2":[31],"groups":[32,154,221],"were":[33,45,51,129,157,189],"compared":[34],"occult":[36],"neoplastic":[37],"cells":[38],"(ONCs)":[39],"in":[40,136,148],"lymph":[42,69],"node":[43],"sinuses":[44],"detected":[46],"by":[47,159],"cytokeratin":[48],"immunohistochemistry.":[49],"There":[50],"significant":[52],"differences":[53],"following":[56,161],"factors:":[57],"venous":[58],"invasion":[59,85,104],"(v-)":[60,80],"vs.":[61,73,81,87,98,106],"(v+)":[62,82,163],"Dukes'":[64,76,91,110,137,149,177,201],"A":[65,92,178],"(p=0.0315);":[67],"harvested":[68],"nodes":[70],"(LN)":[71],"<or=14":[72,166],">or=15":[74],"B":[77,94,138,180],"(p=0.0388);":[79],"(p=0.0059),":[83],"lymphatic":[84],"(ly-)":[86],"(ly+)":[88],"(p=0.0435)":[89],"combined;":[96],"D>n":[97],"D=n":[99],"(p=0.0033),":[100],"depth":[101],"tumor":[103],"<or=ss/a1":[105],">or=se/a2":[107],"(p=0.0329)":[108],"C":[111,150,202],"patients.":[112,151],"When":[113],"detection":[115],">or=3":[117],"ONCs":[118,169,193],"was":[119],"defined":[120],"as":[121,140,142],"positive,":[122],"sensitivity,":[124],"specificity,":[125],"PPV,":[126],"NPV":[128],"respectively":[130],"77%,":[131],"100%,":[132],"100%":[133],"71%":[135],"patients,":[139],"well":[141],"75%,":[143],"72%,":[144],"73%":[145],"74%":[147],"high-risk":[153,218],"identified":[158],"criteria:":[162],"(ly+),":[165],"LN,":[167],"(+)":[170,194],"those":[172,196],"all":[174],"factors":[175,199,209],"(selection":[182,204],"rate,":[183],"approximately":[184,206],"23.5%),":[185],"while":[186],"criteria":[188],"D=n,":[190],">or=se/a2,":[191],">or=2":[198],"rate;":[205],"21.2-37.5%).":[207],"These":[208],"seem":[210],"to":[211],"be":[212],"appropriate":[213],"separating":[215],"into":[217],"low-risk":[220],"cancer":[224],"recurrence/metastasis.":[225]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}