{"id":"https://openalex.org/W2069246700","doi":"https://doi.org/10.1039/p19910003213","title":"Aspartate racemization in synthetic peptides. Part 2. Tendency to racemization of aminosuccinyl residue","display_name":"Aspartate racemization in synthetic peptides. Part 2. Tendency to racemization of aminosuccinyl residue","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2069246700","doi":"https://doi.org/10.1039/p19910003213","mag":"2069246700"},"language":"en","primary_location":{"id":"doi:10.1039/p19910003213","doi":"https://doi.org/10.1039/p19910003213","is_oa":false,"landing_page_url":"https://doi.org/10.1039/p19910003213","pdf_url":null,"source":{"id":"https://openalex.org/S955628534","display_name":"Journal of the Chemical Society Perkin Transactions 1","issn_l":"1364-5463","issn":["1364-5463","1470-4358","1472-7781","2050-8263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J. Chem. Soc., Perkin Trans. 1","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079550606","display_name":"Istv\u00e1n Sch\u00f6n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istv\u00e1n Sch\u00f6n","raw_affiliation_strings":["Gedeon Richter Plc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Plc","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050221076","display_name":"T. Szirtes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tam\u00e1s Szirtes","raw_affiliation_strings":["Gedeon Richter Plc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Plc","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074045533","display_name":"Attila Rill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Attila Rill","raw_affiliation_strings":["Gedeon Richter Plc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Plc","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G\u00e1bor Balogh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2808169635","display_name":"Gedeon Richter (Hungary)","ror":"https://ror.org/0033rtn64","country_code":"HU","type":"company","lineage":["https://openalex.org/I2808169635"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor Balogh","raw_affiliation_strings":["Gedeon Richter Plc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gedeon Richter Plc","institution_ids":["https://openalex.org/I2808169635"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109976004","display_name":"Zsolt Vad\u00e1sz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsolt Vad\u00e1sz","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012463065","display_name":"J\u00e1nos Sepr\u0151di","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00e1nos Sepr\u0151di","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110166652","display_name":"Istv\u00e1n Tepl\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Istv\u00e1n Tepl\u00e1n","raw_affiliation_strings":["Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075159176","display_name":"Naoyoshi Chino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoyoshi Chino","raw_affiliation_strings":["Protein Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Research Foundation","institution_ids":["https://openalex.org/I4210152009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083712685","display_name":"Kumiko Yoshizawa Kumogaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Yoshizawa Kumogaye","raw_affiliation_strings":["Protein Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Research Foundation","institution_ids":["https://openalex.org/I4210152009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069474155","display_name":"Shumpei Sakakibara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Sakakibara","raw_affiliation_strings":["Protein Research Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Research Foundation","institution_ids":["https://openalex.org/I4210152009"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1266,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.39110511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":"12","first_page":"3213","last_page":"3223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epimerization","display_name":"epimerization","score":0.9200000166893005},{"id":"https://openalex.org/keywords/guanidinium-group","display_name":"guanidinium group","score":0.8009999990463257},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pentafluorophenol","display_name":"pentafluorophenol","score":0.7829999923706055},{"id":"https://openalex.org/keywords/strained-ring-systems","display_name":"strained ring systems","score":0.45899999141693115},{"id":"https://openalex.org/keywords/chirality","display_name":"chirality","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C60002323","wikidata":"https://www.wikidata.org/wiki/Q25819","display_name":"Racemization","level":2,"score":0.980014443397522},{"id":"https://openalex.org/C203130289","wikidata":"https://www.wikidata.org/wiki/Q926272","display_name":"Epimer","level":2,"score":0.8895655870437622},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8856219053268433},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.6836625337600708},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.6368532180786133},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6210651993751526},{"id":"https://openalex.org/C2779746882","wikidata":"https://www.wikidata.org/wiki/Q898525","display_name":"Protecting group","level":3,"score":0.5564699172973633},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5557159185409546},{"id":"https://openalex.org/C2777712214","wikidata":"https://www.wikidata.org/wiki/Q409298","display_name":"Dimethylformamide","level":3,"score":0.5487934350967407},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.5436912775039673},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.518349289894104},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22729259729385376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1459411084651947},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.13533952832221985},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.11843317747116089},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/p19910003213","doi":"https://doi.org/10.1039/p19910003213","is_oa":false,"landing_page_url":"https://doi.org/10.1039/p19910003213","pdf_url":null,"source":{"id":"https://openalex.org/S955628534","display_name":"Journal of the Chemical Society Perkin Transactions 1","issn_l":"1364-5463","issn":["1364-5463","1470-4358","1472-7781","2050-8263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J. Chem. Soc., Perkin Trans. 1","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1561131111","https://openalex.org/W1564055638","https://openalex.org/W1582772138","https://openalex.org/W1898812238","https://openalex.org/W1973530563","https://openalex.org/W1982560801","https://openalex.org/W1993307566","https://openalex.org/W1996153172","https://openalex.org/W2006187423","https://openalex.org/W2007788957","https://openalex.org/W2018645065","https://openalex.org/W2028939440","https://openalex.org/W2030481549","https://openalex.org/W2032351349","https://openalex.org/W2032899658","https://openalex.org/W2042020836","https://openalex.org/W2045340850","https://openalex.org/W2066393729","https://openalex.org/W2075385650","https://openalex.org/W2081038525","https://openalex.org/W2094996063","https://openalex.org/W2139129815","https://openalex.org/W2317813738","https://openalex.org/W2322616200","https://openalex.org/W2324887890","https://openalex.org/W2330616386","https://openalex.org/W2403794702","https://openalex.org/W2515622872","https://openalex.org/W2745391785","https://openalex.org/W4300916967","https://openalex.org/W4313371773"],"related_works":["https://openalex.org/W2950455117","https://openalex.org/W2066272096","https://openalex.org/W1534259153","https://openalex.org/W1991348530","https://openalex.org/W2030481549","https://openalex.org/W2166772987","https://openalex.org/W2062561465","https://openalex.org/W2093664636","https://openalex.org/W2044847709","https://openalex.org/W2324366617"],"abstract_inverted_index":{"Aminosuccinyl":[0],"(Asu)":[1],"peptides,":[2,48],"containing":[3],"a":[4,40,95,118],"strained":[5],"ring":[6],"system,":[7],"are":[8],"very":[9],"vulnerable":[10],"to":[11,39,86],"epimerization":[12,29],"and,":[13],"during":[14],"their":[15],"formation,":[16],"even":[17],"as":[18,67],"transients,":[19],"in":[20,84,108],"the":[21,32,50,53,56,59,68,100,109,112,121],"presence":[22,33,110],"of":[23,34,44,52,61,80,111,123],"nucleophilic":[24,35],"and":[25,46],"nonnucleophilic":[26],"bases,":[27,36],"partial":[28],"occurs.":[30],"In":[31,58],"Asu-peptides":[37,74],"transform":[38],"partially":[41],"epimerized":[42],"mixture":[43],"\u03b1-":[45],"\u03b2-aspartyl":[47],"with":[49,103],"preponderance":[51],"\u03b2-":[54],"over":[55],"\u03b1-peptides.":[57],"absence":[60],"any":[62],"internal":[63],"basic":[64,114],"functionality":[65],"such":[66],"protonated":[69],"guanidino":[70],"group,":[71,98],"chirally":[72],"pure":[73],"could":[75],"be":[76],"synthesized":[77],"by":[78,99],"heating":[79],"\u03b2-benzyl-aspartyl":[81],"[Asp(OBzl)]":[82],"peptides":[83,93],"dimethylformamide":[85],"elevated":[87],"temperatures":[88],"or,":[89],"from":[90],"aspartyl":[91],"(Asp)":[92],"having":[94],"free":[96],"carboxy":[97],"usual":[101],"treatment":[102],"pentafluorophenol":[104],"or":[105],"1-hydroxybenzotriazole-dicyclohexylcarbodiimide.":[106],"However,":[107],"strongly":[113],"acetate":[115],"ion":[116],"and/or":[117],"guanidinium":[119],"group":[120],"probability":[122],"aspartate":[124],"racemization":[125],"is":[126],"increased.":[127]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
