{"id":"https://openalex.org/W2069245609","doi":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","title":"Structure-activity relationship studies on the tetrahydroisoquinoline-based orexin 1 receptor antagonists: The 1-benzyl position","display_name":"Structure-activity relationship studies on the tetrahydroisoquinoline-based orexin 1 receptor antagonists: The 1-benzyl position","publication_year":2014,"publication_date":"2014-12-16","ids":{"openalex":"https://openalex.org/W2069245609","doi":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","mag":"2069245609"},"language":"en","primary_location":{"id":"doi:10.1016/j.drugalcdep.2014.09.765","doi":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","pdf_url":null,"source":{"id":"https://openalex.org/S109998069","display_name":"Drug and Alcohol Dependence","issn_l":"0376-8716","issn":["0376-8716","1879-0046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Alcohol Dependence","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100415494","display_name":"Yanan Zhang","orcid":"https://orcid.org/0000-0001-7153-4358","observed_orcids":["https://orcid.org/0000-0001-7153-4358"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanan Zhang","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026978522","display_name":"David A. Perrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Perrey","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062312719","display_name":"Danni L. Harris","orcid":"https://orcid.org/0000-0003-4231-1926","observed_orcids":["https://orcid.org/0000-0003-4231-1926"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danni L. Harris","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054695530","display_name":"Nadezhda German","orcid":"https://orcid.org/0000-0002-8619-9836","observed_orcids":["https://orcid.org/0000-0002-8619-9836"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadezhda A. German","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006323154","display_name":"Ann M. Decker","orcid":"https://orcid.org/0000-0003-1899-6558","observed_orcids":["https://orcid.org/0000-0003-1899-6558"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Decker","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075225919","display_name":"Brian P. Gilmour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P. Gilmour","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102889704","display_name":"Brian F. Thomas","orcid":"https://orcid.org/0000-0002-0097-4804","observed_orcids":["https://orcid.org/0000-0002-0097-4804"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian F. Thomas","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, Unites States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, Unites States","institution_ids":["https://openalex.org/I180297670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180297670"],"apc_list":{"value":4380,"currency":"USD","value_usd":4380},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12857953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"146","issue":null,"first_page":"e31","last_page":"e31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.3711000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.3711000084877014,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.05739999935030937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-1-receptor-antagonist","display_name":"orexin-1 receptor antagonist","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tetrahydroisoquinoline-derivatives","display_name":"tetrahydroisoquinoline derivatives","score":0.8259999752044678},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.7337992191314697},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.49650055170059204},{"id":"https://openalex.org/C2776406546","wikidata":"https://www.wikidata.org/wiki/Q411677","display_name":"Tetrahydroisoquinoline","level":2,"score":0.4900001585483551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4668581783771515},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.422471821308136},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3559191823005676},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3275964856147766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2741463780403137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17642593383789062},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.14657089114189148},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.08332610130310059},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.drugalcdep.2014.09.765","doi":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drugalcdep.2014.09.765","pdf_url":null,"source":{"id":"https://openalex.org/S109998069","display_name":"Drug and Alcohol Dependence","issn_l":"0376-8716","issn":["0376-8716","1879-0046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Alcohol Dependence","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W870632595","https://openalex.org/W1984221372","https://openalex.org/W1977558570","https://openalex.org/W2014767606","https://openalex.org/W3159315792","https://openalex.org/W4234189898","https://openalex.org/W7015610251","https://openalex.org/W2049050064","https://openalex.org/W2524151667","https://openalex.org/W1971807040"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
