{"id":"https://openalex.org/W2069244669","doi":"https://doi.org/10.1002/pros.20935","title":"Gene expression changes are age\u2010dependent and lobe\u2010specific in the brown Norway rat model of prostatic hyperplasia","display_name":"Gene expression changes are age\u2010dependent and lobe\u2010specific in the brown Norway rat model of prostatic hyperplasia","publication_year":2009,"publication_date":"2009-02-09","ids":{"openalex":"https://openalex.org/W2069244669","doi":"https://doi.org/10.1002/pros.20935","mag":"2069244669","pmid":"https://pubmed.ncbi.nlm.nih.gov/19204916","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2732361"},"language":"en","primary_location":{"id":"doi:10.1002/pros.20935","doi":"https://doi.org/10.1002/pros.20935","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pros.20935","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20935","source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20935","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059177259","display_name":"Carlise R. Bethel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlise R. Bethel","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA","Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072992833","display_name":"Jaideep Chaudhary","orcid":"https://orcid.org/0000-0002-8793-4329","observed_orcids":["https://orcid.org/0000-0002-8793-4329"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaideep Chaudhary","raw_affiliation_strings":["Department of Biology, Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, Georgia","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044458790","display_name":"Matthew D. Anway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Anway","raw_affiliation_strings":["Center for Reproductive Biology, Department of Biological Sciences, University of Idaho, Moscow, Idaho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Biology, Department of Biological Sciences, University of Idaho, Moscow, Idaho","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112858789","display_name":"Terry R. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terry R. Brown","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland","Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Room W3606, 615 North Wolfe Street, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Room W3606, 615 North Wolfe Street, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112858789"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":2.7082,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89006578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"69","issue":"8","first_page":"838","last_page":"850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-aging","display_name":"prostate aging","score":0.8809999823570251},{"id":"https://openalex.org/keywords/brown-norway-rats","display_name":"Brown Norway rats","score":0.8700000047683716},{"id":"https://openalex.org/keywords/prostate-lobes","display_name":"prostate lobes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dorsal-lobe","display_name":"dorsal lobe","score":0.699999988079071},{"id":"https://openalex.org/keywords/lateral-lobes","display_name":"lateral lobes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ventral-lobe","display_name":"ventral lobe","score":0.9480000138282776},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.8889999985694885},{"id":"https://openalex.org/keywords/aurora-b-kinase","display_name":"Aurora B kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stmn1","display_name":"STMN1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6862844228744507},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.608934760093689},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.536980926990509},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5216175317764282},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4468041956424713},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42876917123794556},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4249504804611206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3718714714050293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35285940766334534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3306052088737488},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25574517250061035},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2402227222919464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09224170446395874}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/pros.20935","doi":"https://doi.org/10.1002/pros.20935","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pros.20935","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20935","source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:19204916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19204916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2732361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2732361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prostate","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/pros.20935","doi":"https://doi.org/10.1002/pros.20935","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pros.20935","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pros.20935","source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1580754595","display_name":"Effects of Aging on Prostate Structure and Function","funder_award_id":"R01AG020999","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000881543","display_name":"Training in Areas Fundamental to Cancer Research","funder_award_id":"T32CA009110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069244669.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1519298482","https://openalex.org/W1556655356","https://openalex.org/W1586519380","https://openalex.org/W1629666474","https://openalex.org/W1832883470","https://openalex.org/W1977932741","https://openalex.org/W1981237194","https://openalex.org/W1990067517","https://openalex.org/W1995837838","https://openalex.org/W1996447603","https://openalex.org/W1996945731","https://openalex.org/W1997035295","https://openalex.org/W2000561241","https://openalex.org/W2003769343","https://openalex.org/W2019567142","https://openalex.org/W2023980189","https://openalex.org/W2026795048","https://openalex.org/W2032967214","https://openalex.org/W2039569210","https://openalex.org/W2040094738","https://openalex.org/W2040201509","https://openalex.org/W2042706354","https://openalex.org/W2043960690","https://openalex.org/W2055320276","https://openalex.org/W2055498096","https://openalex.org/W2062413481","https://openalex.org/W2063167454","https://openalex.org/W2070479329","https://openalex.org/W2072901239","https://openalex.org/W2075231685","https://openalex.org/W2077021300","https://openalex.org/W2078143431","https://openalex.org/W2079811642","https://openalex.org/W2080555498","https://openalex.org/W2080679821","https://openalex.org/W2082501089","https://openalex.org/W2082810093","https://openalex.org/W2087703443","https://openalex.org/W2089435983","https://openalex.org/W2101571848","https://openalex.org/W2104340629","https://openalex.org/W2106942695","https://openalex.org/W2121352895","https://openalex.org/W2127625548","https://openalex.org/W2129120791","https://openalex.org/W2130247351","https://openalex.org/W2131455628","https://openalex.org/W2133503471","https://openalex.org/W2135951025","https://openalex.org/W2140317464","https://openalex.org/W2144051251","https://openalex.org/W2147224888","https://openalex.org/W2147908233","https://openalex.org/W2148666259","https://openalex.org/W2155660862","https://openalex.org/W2160365040","https://openalex.org/W2162872215","https://openalex.org/W2267247859","https://openalex.org/W2396626466"],"related_works":["https://openalex.org/W2000561241","https://openalex.org/W2023980189","https://openalex.org/W4405023650","https://openalex.org/W2616048890","https://openalex.org/W146536911","https://openalex.org/W2062413481","https://openalex.org/W2085326855","https://openalex.org/W1977807849","https://openalex.org/W2980759079","https://openalex.org/W4415453825"],"abstract_inverted_index":{"BACKGROUND:":[0],"Benign":[1],"prostatic":[2],"hyperplasia":[3,41],"(BPH)":[4],"is":[5,28,35,71],"an":[6],"age-related":[7,182,220],"enlargement":[8],"of":[9,16,26,42,47,63,98,121,127,163,229],"the":[10,24,43,48,68,84,101,135,139,149,154,160,168,226,240,247],"prostate,":[11],"characterized":[12,59],"by":[13,60,79,176],"increased":[14,61],"proliferation":[15],"stromal":[17],"and":[18,50,81,107,111,141,171,193,209,217,231],"epithelial":[19,65],"cells.":[20],"Despite":[21],"its":[22],"prevalence,":[23],"etiology":[25],"BPH":[27],"unknown.":[29],"METHODS:":[30],"The":[31,89,125],"Brown":[32,85],"Norway":[33,86],"rat":[34,87],"a":[36],"model":[37],"for":[38,214],"age-dependent,":[39],"lobe-specific":[40],"prostate.":[44,88,248],"Histological":[45],"analyses":[46],"dorsal":[49,136],"lateral":[51,142,170,227],"lobes":[52,103,173],"from":[53,104],"aged":[54,232],"rats":[55],"reveal":[56],"focal":[57],"areas":[58],"numbers":[62],"luminal":[64],"cells,":[66],"whereas":[67],"ventral":[69,140,172],"lobe":[70,80,228],"unaffected.":[72],"This":[73],"study":[74],"examined":[75],"differential":[76],"gene":[77,117],"expression":[78,99,118,161,186],"age":[82],"in":[83,100,116,134,153,159,167,184,222,225,246],"objective":[90],"was":[91,132,146],"to":[92,112,119,138,239],"identify":[93],"genes":[94,131,152,166],"with":[95,189,244],"different":[96],"levels":[97,162],"prostate":[102,122,194],"4-month":[105],"(young)":[106],"24-month":[108],"(old)":[109],"animals,":[110],"subsequently":[113],"link":[114],"changes":[115,158,221],"mechanisms":[120],"aging.":[123],"RESULTS:":[124],"number":[126],"age-dependent":[128],"differentially":[129,150],"expressed":[130,151],"greatest":[133],"compared":[137],"lobes.":[143,156],"Minimal":[144],"redundancy":[145],"observed":[147],"among":[148],"three":[155],"Age-related":[157],"14":[164],"candidate":[165],"dorsal,":[169],"were":[174,187],"confirmed":[175,219],"quantitative":[177],"RT-PCR.":[178],"Genes":[179],"that":[180],"exhibited":[181],"differences":[183],"their":[185],"associated":[188,243],"proliferation,":[190],"oxidative":[191],"stress,":[192],"cancer":[195],"progression,":[196],"including":[197],"topoisomerase":[198],"II":[199],"alpha":[200],"(Topo2a),":[201],"aurora":[202],"kinase":[203],"B":[204],"(Aurkb),":[205],"stathmin":[206],"1":[207],"(Stmn1),":[208],"glutathione":[210],"S-transferase":[211],"pi.":[212],"Immunohistochemistry":[213],"Topo2a,":[215],"Aurkb,":[216],"Stmn1":[218],"protein":[223],"localization":[224],"young":[230],"prostates.":[233],"CONCLUSION:":[234],"These":[235],"findings":[236],"provide":[237],"clues":[238],"molecular":[241],"events":[242],"aging":[245]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}