{"id":"https://openalex.org/W2069218841","doi":"https://doi.org/10.1002/mrd.20599","title":"Pronuclear stage porcine embryos do not possess a strict asymmetric distribution of lysine 9 dimethylation of histone H3 based solely on parental origin","display_name":"Pronuclear stage porcine embryos do not possess a strict asymmetric distribution of lysine 9 dimethylation of histone H3 based solely on parental origin","publication_year":2006,"publication_date":"2006-08-29","ids":{"openalex":"https://openalex.org/W2069218841","doi":"https://doi.org/10.1002/mrd.20599","mag":"2069218841","pmid":"https://pubmed.ncbi.nlm.nih.gov/16941674"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.20599","doi":"https://doi.org/10.1002/mrd.20599","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.20599","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057172490","display_name":"Martiana F. Sega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martiana F. Sega","raw_affiliation_strings":["Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA","Department of Animal Sciences, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046922025","display_name":"Kiho Lee","orcid":"https://orcid.org/0000-0003-3549-631X","observed_orcids":["https://orcid.org/0000-0003-3549-631X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiho Lee","raw_affiliation_strings":["Department of Animal Sciences, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015759451","display_name":"Zolt\u00e1n Mach\u00e1ty","orcid":"https://orcid.org/0000-0001-9021-1706","observed_orcids":["https://orcid.org/0000-0001-9021-1706"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoltan Machaty","raw_affiliation_strings":["Department of Animal Sciences, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089469547","display_name":"Ryan A. Cabot","orcid":"https://orcid.org/0000-0002-4790-9655","observed_orcids":["https://orcid.org/0000-0002-4790-9655"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan Cabot","raw_affiliation_strings":["Department of Animal Sciences, Purdue University, West Lafayette, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, Purdue University, West Lafayette, Indiana","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089469547"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":0.2717,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.54592566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"74","issue":"1","first_page":"2","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k9-dimethylation","display_name":"H3K9 dimethylation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/h3k9","display_name":"H3K9","score":0.890999972820282},{"id":"https://openalex.org/keywords/pronuclear-stage-embryos","display_name":"pronuclear stage embryos","score":0.7789999842643738},{"id":"https://openalex.org/keywords/porcine-embryos","display_name":"porcine embryos","score":0.9570000171661377},{"id":"https://openalex.org/keywords/parent-of-origin","display_name":"parent of origin","score":0.7099999785423279},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.6779999732971191},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.5540000200271606},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.7080000042915344},{"id":"https://openalex.org/keywords/blastocyst","display_name":"blastocyst","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cleavage-stage-embryos","display_name":"cleavage-stage embryos","score":0.6159999966621399},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8814213275909424},{"id":"https://openalex.org/C110758877","wikidata":"https://www.wikidata.org/wiki/Q2614103","display_name":"Pronucleus","level":5,"score":0.6642800569534302},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.6628386974334717},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6531260013580322},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5968992710113525},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5830925107002258},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.5664405822753906},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5495790243148804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46833205223083496},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.45096567273139954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4486074447631836},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4328344166278839},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4293849766254425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31159746646881104},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.23670262098312378},{"id":"https://openalex.org/C28748434","wikidata":"https://www.wikidata.org/wiki/Q170145","display_name":"Zygote","level":4,"score":0.20810189843177795}],"mesh":[{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010312","descriptor_name":"Parthenogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.20599","doi":"https://doi.org/10.1002/mrd.20599","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.20599","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:16941674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16941674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W589535273","https://openalex.org/W1485757354","https://openalex.org/W1486183464","https://openalex.org/W1511815964","https://openalex.org/W1969345130","https://openalex.org/W1971633031","https://openalex.org/W1973696025","https://openalex.org/W1973727308","https://openalex.org/W1978386737","https://openalex.org/W1997605505","https://openalex.org/W2002698073","https://openalex.org/W2007367058","https://openalex.org/W2013571070","https://openalex.org/W2014286894","https://openalex.org/W2017714279","https://openalex.org/W2029903254","https://openalex.org/W2035915355","https://openalex.org/W2058607217","https://openalex.org/W2059074286","https://openalex.org/W2059154956","https://openalex.org/W2064358462","https://openalex.org/W2071953998","https://openalex.org/W2075907707","https://openalex.org/W2078362264","https://openalex.org/W2098094952","https://openalex.org/W2114081032","https://openalex.org/W2117069375","https://openalex.org/W2127431151","https://openalex.org/W2143027433","https://openalex.org/W2144792857","https://openalex.org/W2146091491","https://openalex.org/W2156371750","https://openalex.org/W2158562032","https://openalex.org/W2171767359","https://openalex.org/W2340690337","https://openalex.org/W2415571067","https://openalex.org/W2469747861","https://openalex.org/W4213311240","https://openalex.org/W4237441795","https://openalex.org/W4247418383","https://openalex.org/W4300977553","https://openalex.org/W6743775608"],"related_works":["https://openalex.org/W1972884589","https://openalex.org/W1979471173","https://openalex.org/W2007097480","https://openalex.org/W2596045802","https://openalex.org/W2171767359","https://openalex.org/W1585573639","https://openalex.org/W2415571067","https://openalex.org/W2007367058","https://openalex.org/W2499374587","https://openalex.org/W1485757354"],"abstract_inverted_index":{"Epigenetic":[0],"modification":[1,89],"of":[2,23,28,37,51,55,68,95,120,124,140],"core":[3],"histone":[4,29],"proteins":[5],"plays":[6],"an":[7,117],"important":[8],"role":[9],"in":[10,63,78,112,145],"gene":[11],"transcription":[12,38],"and":[13,39,99],"chromatin":[14],"structure.":[15],"It":[16,42],"is":[17,32,90,142],"known":[18],"that":[19,46,87,138],"the":[20,24,52,59,74,93,106,109,121,133],"methylation":[21],"status":[22],"lysine":[25],"9":[26],"residue":[27],"H3":[30],"(H3K9)":[31],"closely":[33],"linked":[34],"with":[35],"repression":[36],"heterochromatin":[40],"formation.":[41],"has":[43],"been":[44],"reported":[45],"a":[47],"strict":[48],"asymmetric":[49,118],"distribution":[50,119,127],"dimethylated":[53,122],"form":[54,123],"H3K9":[56,75,141],"exists":[57],"between":[58],"two":[60],"parental":[61],"genomes":[62],"murine":[64],"embryos.":[65,82,103,149],"The":[66],"aim":[67],"this":[69,88,126],"study":[70],"was":[71,128],"to":[72],"characterize":[73],"dimethylation":[76,139],"pattern":[77],"cleavage":[79],"stage":[80,101,108,147],"porcine":[81,102,114,148],"Indirect":[83],"immunocytochemical":[84],"analysis":[85],"showed":[86],"present":[91],"throughout":[92],"nuclei":[94],"pronuclear,":[96],"2-cell,":[97],"4-cell":[98],"blastocyst":[100],"However,":[104],"at":[105],"pronuclear":[107,146],"pronuclei":[110],"within":[111],"vitro-fertilized":[113],"embryos":[115],"possessed":[116],"H3K9;":[125],"not":[129],"based":[130],"solely":[131],"on":[132],"parent-of-origin.":[134],"These":[135],"results":[136],"show":[137],"differentially":[143],"regulated":[144]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
