{"id":"https://openalex.org/W2069210641","doi":"https://doi.org/10.1021/ja016285c","title":"Consistent Helicities from CD and Template t/c Data for N-Templated Polyalanines: Progress toward Resolution of the Alanine Helicity Problem","display_name":"Consistent Helicities from CD and Template t/c Data for N-Templated Polyalanines: Progress toward Resolution of the Alanine Helicity Problem","publication_year":2002,"publication_date":"2002-01-18","ids":{"openalex":"https://openalex.org/W2069210641","doi":"https://doi.org/10.1021/ja016285c","mag":"2069210641","pmid":"https://pubmed.ncbi.nlm.nih.gov/11829601"},"language":"en","primary_location":{"id":"doi:10.1021/ja016285c","doi":"https://doi.org/10.1021/ja016285c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja016285c","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053292728","display_name":"Robert J. Kennedy","orcid":"https://orcid.org/0000-0002-4602-1240","observed_orcids":["https://orcid.org/0000-0002-4602-1240"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Kennedy","raw_affiliation_strings":["Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kwok-Yin Tsang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwok-Yin Tsang","raw_affiliation_strings":["Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108450267","display_name":"Daniel S. Kemp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Kemp","raw_affiliation_strings":["Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, Room 18-582, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0854,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86587501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"124","issue":"6","first_page":"934","last_page":"944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-c-ratio","display_name":"T/C ratio","score":0.5299999713897705},{"id":"https://openalex.org/keywords/helical-propensity","display_name":"helical propensity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/alanine-rich-peptides","display_name":"alanine-rich peptides","score":0.7789999842643738},{"id":"https://openalex.org/keywords/peptide-solubilization","display_name":"peptide solubilization","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8880897760391235},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.8642381429672241},{"id":"https://openalex.org/C2775859700","wikidata":"https://www.wikidata.org/wiki/Q568855","display_name":"Helicity","level":2,"score":0.6938267946243286},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.6235418915748596},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5924121737480164},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5604937076568604},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4919578731060028},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4863491654396057},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.47317197918891907},{"id":"https://openalex.org/C97514900","wikidata":"https://www.wikidata.org/wiki/Q719597","display_name":"Energetics","level":2,"score":0.44899529218673706},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.416703462600708},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.23500826954841614},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.14642149209976196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12974023818969727},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11783775687217712},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06951525807380676},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06607586145401001},{"id":"https://openalex.org/C109214941","wikidata":"https://www.wikidata.org/wiki/Q18334","display_name":"Particle physics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja016285c","doi":"https://doi.org/10.1021/ja016285c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja016285c","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:11829601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11829601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333120","display_name":"Holden Comprehensive Cancer Center, University of Iowa","ror":"https://ror.org/01jhe7086"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1979528014","https://openalex.org/W1981654841","https://openalex.org/W1981761838","https://openalex.org/W1983161380","https://openalex.org/W1993273221","https://openalex.org/W1999330255","https://openalex.org/W2000842457","https://openalex.org/W2003761926","https://openalex.org/W2014550271","https://openalex.org/W2029307678","https://openalex.org/W2043514891","https://openalex.org/W2043793450","https://openalex.org/W2047219805","https://openalex.org/W2053127968","https://openalex.org/W2054093296","https://openalex.org/W2054248113","https://openalex.org/W2057553906","https://openalex.org/W2076469439","https://openalex.org/W2083863413","https://openalex.org/W2086650023","https://openalex.org/W2090022310","https://openalex.org/W2094920965","https://openalex.org/W2126912623","https://openalex.org/W2949731935","https://openalex.org/W2950805015"],"related_works":["https://openalex.org/W1969546170","https://openalex.org/W2069810636","https://openalex.org/W2052045239","https://openalex.org/W2089848832","https://openalex.org/W2034478733","https://openalex.org/W2047428464","https://openalex.org/W1974749892","https://openalex.org/W2151654128","https://openalex.org/W2060003952","https://openalex.org/W1481869021"],"abstract_inverted_index":{"The":[0,147],"helicity":[1],"reporting":[2],"parameters":[3],"t/c":[4,54,108],"and":[5,13,40,44,84,106,109,139],"[theta](222)":[6,110],"have":[7],"been":[8],"measured":[9],"at":[10,118],"2,":[11],"25,":[12],"60":[14],"degrees":[15,120],"C":[16,121],"in":[17,81],"water":[18],"for":[19,62,88,124,129,141,152],"the":[20,38,45,59,153],"solubilized":[21],"polyalanine":[22],"series":[23],"Ac-Hel-A(n)-(t)LInp(2)K(4)W-NH(2)":[24],"of":[25,53,122,149,155],"length":[26,56],"4":[27],"<":[28,32,64,131,135],"or":[29,33,65,91,132,136,144],"=":[30,34,66,92,126,133,137,145],"n":[31,63,89,125,134,142],"14":[35],"that":[36,58,77],"bears":[37],"helix-initiating":[39],"monitoring":[41],"N-cap":[42],"Ac-Hel":[43],"spaced":[46],"solubilizer":[47],"(t)LInp(2)K(4)W-NH(2)":[48],"as":[49],"a":[50,78],"C-cap.":[51],"Correlation":[52],"with":[55,72],"shows":[57],"helical":[60,85],"propensity":[61,86],"6":[67],"is":[68,100],"ca.":[69],"1.0,":[70],"consistent":[71],"our":[73],"early":[74],"reports,":[75],"but":[76],"dramatic":[79],"increase":[80],"temperature":[82],"dependence":[83],"occurs":[87],">":[90,143],"8.":[93],"A":[94],"model":[95],"based":[96],"on":[97],"hydrogen-bonding":[98],"cooperativity":[99],"proposed":[101],"to":[102],"explain":[103],"this":[104],"finding,":[105],"both":[107],"are":[111,162],"modeled":[112],"successfully":[113],"by":[114,158],"length-dependent":[115],"alanine":[116],"propensities":[117],"2":[119],"1.03":[123],"6,":[127],"1.15,":[128],"7":[130],"9":[138],"1.26":[140],"10.":[146],"implications":[148],"these":[150],"results":[151],"energetics":[154],"helix":[156],"formation":[157],"alanine-rich":[159],"peptide":[160],"sequences":[161],"discussed.":[163]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}