{"id":"https://openalex.org/W2069208203","doi":"https://doi.org/10.1016/j.ejca.2005.01.021","title":"Effects of chemotherapy on endogenous erythropoietin levels and the pharmacokinetics and erythropoietic response of darbepoetin alfa: A randomised clinical trial of synchronous versus asynchronous dosing of darbepoetin alfa","display_name":"Effects of chemotherapy on endogenous erythropoietin levels and the pharmacokinetics and erythropoietic response of darbepoetin alfa: A randomised clinical trial of synchronous versus asynchronous dosing of darbepoetin alfa","publication_year":2005,"publication_date":"2005-04-09","ids":{"openalex":"https://openalex.org/W2069208203","doi":"https://doi.org/10.1016/j.ejca.2005.01.021","mag":"2069208203","pmid":"https://pubmed.ncbi.nlm.nih.gov/15911237"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejca.2005.01.021","doi":"https://doi.org/10.1016/j.ejca.2005.01.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2005.01.021","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080006341","display_name":"John A. Glaspy","orcid":"https://orcid.org/0000-0002-1800-9076","observed_orcids":["https://orcid.org/0000-0002-1800-9076"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Glaspy","raw_affiliation_strings":["UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA. jglaspy@mednet.ucla.edu","UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA. jglaspy@mednet.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105511082","display_name":"David H. Henry","orcid":"https://orcid.org/0000-0002-9122-2623","observed_orcids":["https://orcid.org/0000-0002-9122-2623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Henry","raw_affiliation_strings":["Joan Karnell Cancer Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joan Karnell Cancer Center, Philadelphia, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047556737","display_name":"Ravi Patel","orcid":"https://orcid.org/0000-0001-6366-2122","observed_orcids":["https://orcid.org/0000-0001-6366-2122"]},"institutions":[{"id":"https://openalex.org/I4210133297","display_name":"Comprehensive Blood & Cancer Center","ror":"https://ror.org/02vz7hv03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Patel","raw_affiliation_strings":["Comprehensive Blood and Cancer Center, Bakersfield, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Blood and Cancer Center, Bakersfield, CA, USA","institution_ids":["https://openalex.org/I4210133297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005016975","display_name":"Simon Tchekmedyian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Tchekmedyian","raw_affiliation_strings":["Pacific Shores Medical Group, Long Beach, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Shores Medical Group, Long Beach, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056192655","display_name":"Steve Applebaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Applebaum","raw_affiliation_strings":["UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, School of Medicine, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA 90095-6956, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066328151","display_name":"Donald H. Berdeaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Berdeaux","raw_affiliation_strings":["Great Falls, MT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Great Falls, MT, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Lloyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Lloyd","raw_affiliation_strings":["Virginia K. Crosson Cancer Center, Fullerton, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia K. Crosson Cancer Center, Fullerton, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520333","display_name":"R. Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell Berg","raw_affiliation_strings":["Amgen, Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110891929","display_name":"Matt Austin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Austin","raw_affiliation_strings":["Amgen, Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103550456","display_name":"Greg Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Rossi","raw_affiliation_strings":["Amgen, Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen, Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080006341"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":8.8237,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.98253904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"41","issue":"8","first_page":"1140","last_page":"1149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/darbepoetin-alfa","display_name":"darbepoetin alfa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endogenous-erythropoietin","display_name":"endogenous erythropoietin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cancer-related-anemia","display_name":"cancer-related anemia","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hemoglobin-response","display_name":"hemoglobin response","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2781404941","wikidata":"https://www.wikidata.org/wiki/Q2178381","display_name":"Darbepoetin alfa","level":3,"score":0.9289989471435547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8067331314086914},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.7553357481956482},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6375168561935425},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6292707920074463},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6167782545089722},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5015089511871338},{"id":"https://openalex.org/C2776164570","wikidata":"https://www.wikidata.org/wiki/Q5383794","display_name":"Epoetin alfa","level":3,"score":0.46797966957092285},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4669189453125},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.46153223514556885},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4438120424747467},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.43039751052856445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3411135673522949}],"mesh":[{"descriptor_ui":"D000068256","descriptor_name":"Darbepoetin alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejca.2005.01.021","doi":"https://doi.org/10.1016/j.ejca.2005.01.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejca.2005.01.021","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:15911237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15911237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer (Oxford, England : 1990)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W178074431","https://openalex.org/W311531870","https://openalex.org/W1486959216","https://openalex.org/W1821554592","https://openalex.org/W1848812419","https://openalex.org/W1867073577","https://openalex.org/W1884165293","https://openalex.org/W1885881044","https://openalex.org/W1964818405","https://openalex.org/W1967932960","https://openalex.org/W1987307200","https://openalex.org/W1996698172","https://openalex.org/W2002395765","https://openalex.org/W2007313133","https://openalex.org/W2012264968","https://openalex.org/W2031496147","https://openalex.org/W2039728906","https://openalex.org/W2058907838","https://openalex.org/W2060343405","https://openalex.org/W2063440159","https://openalex.org/W2067622076","https://openalex.org/W2080776158","https://openalex.org/W2093666912","https://openalex.org/W2096598341","https://openalex.org/W2101221327","https://openalex.org/W2109024675","https://openalex.org/W2119797748","https://openalex.org/W2126512507","https://openalex.org/W2146353390","https://openalex.org/W2163830215","https://openalex.org/W2166041551","https://openalex.org/W2169177790","https://openalex.org/W2264645549","https://openalex.org/W2272758509","https://openalex.org/W2285385630","https://openalex.org/W2327746907","https://openalex.org/W2402920574","https://openalex.org/W2414479032","https://openalex.org/W2415159961","https://openalex.org/W2473305002","https://openalex.org/W2597010269","https://openalex.org/W2796700885","https://openalex.org/W2941660277","https://openalex.org/W2991921109","https://openalex.org/W3015973740","https://openalex.org/W4235907762","https://openalex.org/W6694235489","https://openalex.org/W6701518581","https://openalex.org/W6735155731","https://openalex.org/W6761705145"],"related_works":["https://openalex.org/W2442528111","https://openalex.org/W2054849245","https://openalex.org/W2064984507","https://openalex.org/W1969736548","https://openalex.org/W2012264968","https://openalex.org/W2013653055","https://openalex.org/W1987904872","https://openalex.org/W2132195012","https://openalex.org/W2030211882","https://openalex.org/W2149721168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}