{"id":"https://openalex.org/W2069196865","doi":"https://doi.org/10.1080/0144361021000043263","title":"Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss","display_name":"Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2069196865","doi":"https://doi.org/10.1080/0144361021000043263","mag":"2069196865","pmid":"https://pubmed.ncbi.nlm.nih.gov/12623486"},"language":"en","primary_location":{"id":"doi:10.1080/0144361021000043263","doi":"https://doi.org/10.1080/0144361021000043263","is_oa":false,"landing_page_url":"https://doi.org/10.1080/0144361021000043263","pdf_url":null,"source":{"id":"https://openalex.org/S35334646","display_name":"Journal of Obstetrics and Gynaecology","issn_l":"0144-3615","issn":["0144-3615","1364-6893"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052875301","display_name":"K.S.D. Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105935","display_name":"Institute of Genetics and Hospital for Genetic Diseases","ror":"https://ror.org/01bqrhe48","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210105935","https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. S. D. Kumar","raw_affiliation_strings":["Institute of Genetics, Hyderabad, India. ksdkumar@rediffmail.com","Institute of Genetics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Hyderabad, India. ksdkumar@rediffmail.com","institution_ids":["https://openalex.org/I4210105935"]},{"raw_affiliation_string":"Institute of Genetics, Hyderabad, India","institution_ids":["https://openalex.org/I4210105935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000655221","display_name":"Govindaiah Vinukonda","orcid":"https://orcid.org/0000-0002-6065-3092","observed_orcids":["https://orcid.org/0000-0002-6065-3092"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. Govindaiah","raw_affiliation_strings":["Center for DNA Finger Printing and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for DNA Finger Printing and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050781851","display_name":"Shaik Mohammad Naushad","orcid":"https://orcid.org/0000-0001-8952-9581","observed_orcids":["https://orcid.org/0000-0001-8952-9581"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. E. Naushad","raw_affiliation_strings":["Center for DNA Finger Printing and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for DNA Finger Printing and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110134054","display_name":"RK Rupabati Devi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. R. Devi","raw_affiliation_strings":["Center for DNA Finger Printing and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for DNA Finger Printing and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046438096","display_name":"Akka Jyothy","orcid":"https://orcid.org/0000-0003-0728-9022","observed_orcids":["https://orcid.org/0000-0003-0728-9022"]},"institutions":[{"id":"https://openalex.org/I4210105935","display_name":"Institute of Genetics and Hospital for Genetic Diseases","ror":"https://ror.org/01bqrhe48","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210105935","https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Jyothy","raw_affiliation_strings":["Institute of Genetics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Hyderabad, India","institution_ids":["https://openalex.org/I4210105935"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3265,"currency":"AUD","value_usd":2390},"apc_paid":null,"fwci":3.6836,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.92542398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"55","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.8389999866485596},{"id":"https://openalex.org/keywords/red-blood-cell-folate","display_name":"red blood cell folate","score":0.8679999709129333},{"id":"https://openalex.org/keywords/plasma-homocysteine","display_name":"plasma homocysteine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.5659999847412109},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.7429999709129333},{"id":"https://openalex.org/keywords/unexplained-pregnancy-loss","display_name":"unexplained pregnancy loss","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9383702278137207},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.8501002788543701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8023084998130798},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6981345415115356},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.6183151006698608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5993765592575073},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5804001092910767},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.525611162185669},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5031201243400574},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.4433631896972656},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4375571012496948},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4150000214576721},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1985051929950714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18312108516693115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16181835532188416},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15239760279655457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09427791833877563},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000026","descriptor_name":"Abortion, Habitual","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000026","descriptor_name":"Abortion, Habitual","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000026","descriptor_name":"Abortion, Habitual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000587","descriptor_name":"Oxidoreductases Acting on CH-NH Group Donors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/0144361021000043263","doi":"https://doi.org/10.1080/0144361021000043263","is_oa":false,"landing_page_url":"https://doi.org/10.1080/0144361021000043263","pdf_url":null,"source":{"id":"https://openalex.org/S35334646","display_name":"Journal of Obstetrics and Gynaecology","issn_l":"0144-3615","issn":["0144-3615","1364-6893"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},{"id":"pmid:12623486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12623486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1967406778","https://openalex.org/W2008031088","https://openalex.org/W2018543430","https://openalex.org/W2048371995","https://openalex.org/W2050478304","https://openalex.org/W2057680971","https://openalex.org/W2073646360","https://openalex.org/W2077380255","https://openalex.org/W2090474126","https://openalex.org/W2097196943","https://openalex.org/W2126411027","https://openalex.org/W2151172455","https://openalex.org/W2162413081","https://openalex.org/W2165715420","https://openalex.org/W2430448184"],"related_works":["https://openalex.org/W2143504971","https://openalex.org/W2048371995","https://openalex.org/W2011684895","https://openalex.org/W2726892492","https://openalex.org/W2994679642","https://openalex.org/W2070108002","https://openalex.org/W2368788912","https://openalex.org/W2164168094","https://openalex.org/W7207252057","https://openalex.org/W4297102118"],"abstract_inverted_index":{"Hyperhomocysteinaemia,":[0],"a":[1,12,25,117,265],"risk":[2,118],"factor":[3,119],"for":[4,120,213,221],"recurrent":[5,76,121,237,254],"pregnancy":[6,77,123,238,255],"loss,":[7,124],"is":[8],"related":[9],"either":[10],"to":[11,38,52,95,115,160,180,210],"hereditary":[13],"defect":[14],"within":[15],"the":[16,47,55,64,87,103,131,137,156,175,187,195,201,214,222,242],"methionine-homocysteine":[17],"pathway":[18],"or":[19,73],"it":[20,189],"might":[21,263],"be":[22,39,116,181,211],"acquired":[23],"as":[24],"result":[26],"of":[27,29,229,249],"deficiencies":[28],"vitamin":[30],"B(12)":[31],"and":[32,44,60,134,204,245,262],"folate":[33,58,142,172,246],"(B(9)).":[34],"Because":[35],"hyperhomocysteinaemia":[36,250],"seems":[37],"determined":[40],"by":[41],"both":[42,241],"genetic":[43],"environmental":[45],"factors,":[46],"current":[48],"study":[49,88,132,157,176,197,202],"was":[50,90,113,125,178,190],"undertaken":[51],"find":[53],"out":[54],"interactions":[56],"between":[57],"status":[59],"MTHFR":[61,216],"mutation":[62],"on":[63],"homocysteine":[65,84,106,230],"concentration":[66,85,231],"in":[67,86,102,127,130,151,174,186,200,234,251,259],"24":[68],"women":[69,129,154,163,199,235,252],"experiencing":[70,236],"unexplained":[71],"three":[72],"more":[74],"consecutive":[75],"losses.":[78],"The":[79,166,226],"median":[80],"fasting":[81],"total":[82],"plasma":[83],"group":[89,133,177,203],"10.23":[91],"micro":[92,97,110],"mol/l":[93],"compared":[94,159],"8.95":[96],"mol/l;":[98],"P":[99],"=":[100],"0.096":[101],"controls.":[104,138,165],"Elevated":[105],"levels":[107,143,173],">":[108],"18":[109],"mol/l,":[111],"which":[112],"considered":[114],"early":[122],"found":[126,179,209,233],"four":[128],"none":[135],"among":[136,155,164,206],"Lower":[139],"red":[140,170],"cell":[141,171],"(normal":[144],"range":[145],">/=":[146],"160":[147],"ng/ml)":[148],"were":[149,208,219,232],"observed":[150],"nine":[152],"(37.5%)":[153],"group,":[158],"five":[161],"(20.84%)":[162],"mean":[167],"+/-":[168,183,192],"SD":[169],"154.37":[182],"37.07,":[184],"while":[185],"controls":[188,207],"159.0":[191],"28.97.":[193],"In":[194],"present":[196],"six":[198],"two":[205],"carriers":[212],"C677T":[215],"mutation.":[217],"None":[218],"homozygous":[220],"mutant":[223],"(TT)":[224],"allele.":[225],"highest":[227],"values":[228],"loss":[239,256],"with":[240,253],"CT":[243],"genotype":[244],"deficiency.":[247],"Identification":[248],"may":[257],"help":[258],"therapeutic":[260],"normalisation":[261],"permit":[264],"normal":[266],"birth.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
