{"id":"https://openalex.org/W2069137146","doi":"https://doi.org/10.1016/j.tox.2004.11.023","title":"Peroxynitrite and drug-dependent toxicity","display_name":"Peroxynitrite and drug-dependent toxicity","publication_year":2004,"publication_date":"2004-12-29","ids":{"openalex":"https://openalex.org/W2069137146","doi":"https://doi.org/10.1016/j.tox.2004.11.023","mag":"2069137146","pmid":"https://pubmed.ncbi.nlm.nih.gov/15691591"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2004.11.023","doi":"https://doi.org/10.1016/j.tox.2004.11.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2004.11.023","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038220750","display_name":"Ana Denicola","orcid":"https://orcid.org/0000-0002-5181-9708","observed_orcids":["https://orcid.org/0000-0002-5181-9708"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Ana Denicola","raw_affiliation_strings":["Lab. Fisicoqu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Igu\u00e1 4225, 11400 Montevideo, Uruguay. denicola@fcien.edu.uy","Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay","Lab. Fisicoqu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Igu\u00e1 4225, 11400 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab. Fisicoqu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Igu\u00e1 4225, 11400 Montevideo, Uruguay. denicola@fcien.edu.uy","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Lab. Fisicoqu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Igu\u00e1 4225, 11400 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay","Depto. Bioqu\u00edmica, Facultad de Medicina, Avda. Gral. Flores 2125, 11800 Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Depto. Bioqu\u00edmica, Facultad de Medicina, Avda. Gral. Flores 2125, 11800 Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038220750","https://openalex.org/A5073926538"],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":4.3514,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95523633,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"208","issue":"2","first_page":"273","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":1.0},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.921999990940094},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.699999988079071},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-uncoupling","display_name":"nitric oxide synthase uncoupling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.6549999713897705},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7139999866485596},{"id":"https://openalex.org/keywords/paraquat","display_name":"paraquat","score":0.9980000257492065},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5099999904632568},{"id":"https://openalex.org/keywords/peroxynitrite-scavengers","display_name":"peroxynitrite scavengers","score":0.9120000004768372},{"id":"https://openalex.org/keywords/superoxide-dismutase-mimics","display_name":"superoxide dismutase mimetic","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.4699999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.9901613593101501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7936129570007324},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7367823123931885},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6343809366226196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5228779315948486},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.511284589767456},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4853705167770386},{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.4551709294319153},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.45105069875717163},{"id":"https://openalex.org/C2777103536","wikidata":"https://www.wikidata.org/wiki/Q7169514","display_name":"Peroxynitrous acid","level":5,"score":0.4226924180984497},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41611456871032715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3806276321411133},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20464491844177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1099574863910675},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030421","descriptor_name":"Peroxynitrous Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2004.11.023","doi":"https://doi.org/10.1016/j.tox.2004.11.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2004.11.023","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:15691591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15691591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":180,"referenced_works":["https://openalex.org/W35243478","https://openalex.org/W92884246","https://openalex.org/W125325141","https://openalex.org/W166590346","https://openalex.org/W222737829","https://openalex.org/W943135624","https://openalex.org/W1489860413","https://openalex.org/W1499834471","https://openalex.org/W1505685265","https://openalex.org/W1506033534","https://openalex.org/W1530199299","https://openalex.org/W1546267534","https://openalex.org/W1580002784","https://openalex.org/W1597212188","https://openalex.org/W1632979324","https://openalex.org/W1668019941","https://openalex.org/W1709336739","https://openalex.org/W1725300350","https://openalex.org/W1761291408","https://openalex.org/W1821918060","https://openalex.org/W1832691281","https://openalex.org/W1943182047","https://openalex.org/W1945990234","https://openalex.org/W1952918366","https://openalex.org/W1964555546","https://openalex.org/W1964671322","https://openalex.org/W1964876495","https://openalex.org/W1966078885","https://openalex.org/W1967315269","https://openalex.org/W1968473228","https://openalex.org/W1969800514","https://openalex.org/W1969941249","https://openalex.org/W1970184435","https://openalex.org/W1970711821","https://openalex.org/W1970974990","https://openalex.org/W1972989329","https://openalex.org/W1974358158","https://openalex.org/W1974759748","https://openalex.org/W1975406229","https://openalex.org/W1977922788","https://openalex.org/W1978245407","https://openalex.org/W1981502718","https://openalex.org/W1982422614","https://openalex.org/W1983588291","https://openalex.org/W1983754228","https://openalex.org/W1984001765","https://openalex.org/W1984775666","https://openalex.org/W1987758728","https://openalex.org/W1987861061","https://openalex.org/W1988849173","https://openalex.org/W1989392302","https://openalex.org/W1990355599","https://openalex.org/W1991844778","https://openalex.org/W1991960933","https://openalex.org/W1992786087","https://openalex.org/W1997071370","https://openalex.org/W1999138947","https://openalex.org/W1999649376","https://openalex.org/W2005408885","https://openalex.org/W2005740482","https://openalex.org/W2005890826","https://openalex.org/W2005998580","https://openalex.org/W2009279488","https://openalex.org/W2009506745","https://openalex.org/W2010273334","https://openalex.org/W2010357952","https://openalex.org/W2011166211","https://openalex.org/W2011552468","https://openalex.org/W2011777799","https://openalex.org/W2011948827","https://openalex.org/W2012018808","https://openalex.org/W2018380711","https://openalex.org/W2018685529","https://openalex.org/W2019408224","https://openalex.org/W2019859522","https://openalex.org/W2020105615","https://openalex.org/W2020893327","https://openalex.org/W2022377100","https://openalex.org/W2022458326","https://openalex.org/W2023093466","https://openalex.org/W2023671075","https://openalex.org/W2023677185","https://openalex.org/W2024092039","https://openalex.org/W2024994588","https://openalex.org/W2026183999","https://openalex.org/W2026425756","https://openalex.org/W2028050317","https://openalex.org/W2028142995","https://openalex.org/W2029246446","https://openalex.org/W2029587579","https://openalex.org/W2031051734","https://openalex.org/W2032465415","https://openalex.org/W2032890845","https://openalex.org/W2034158879","https://openalex.org/W2035158815","https://openalex.org/W2035632074","https://openalex.org/W2038557175","https://openalex.org/W2039240565","https://openalex.org/W2039818533","https://openalex.org/W2040460879","https://openalex.org/W2042853579","https://openalex.org/W2044606744","https://openalex.org/W2044800103","https://openalex.org/W2046798893","https://openalex.org/W2047217255","https://openalex.org/W2047602901","https://openalex.org/W2047936141","https://openalex.org/W2048650123","https://openalex.org/W2049113108","https://openalex.org/W2051354345","https://openalex.org/W2051809818","https://openalex.org/W2052350481","https://openalex.org/W2052548407","https://openalex.org/W2054425281","https://openalex.org/W2055420058","https://openalex.org/W2056584805","https://openalex.org/W2057210041","https://openalex.org/W2057483650","https://openalex.org/W2058013605","https://openalex.org/W2058137293","https://openalex.org/W2059646723","https://openalex.org/W2061419115","https://openalex.org/W2061995199","https://openalex.org/W2062753806","https://openalex.org/W2063853976","https://openalex.org/W2063873306","https://openalex.org/W2065796822","https://openalex.org/W2067498906","https://openalex.org/W2067816697","https://openalex.org/W2068089631","https://openalex.org/W2070158477","https://openalex.org/W2070831525","https://openalex.org/W2071321282","https://openalex.org/W2073224154","https://openalex.org/W2076828323","https://openalex.org/W2076894643","https://openalex.org/W2076911700","https://openalex.org/W2080731306","https://openalex.org/W2085366528","https://openalex.org/W2086122328","https://openalex.org/W2086506907","https://openalex.org/W2087830809","https://openalex.org/W2088088066","https://openalex.org/W2088323144","https://openalex.org/W2089157516","https://openalex.org/W2089732371","https://openalex.org/W2095397705","https://openalex.org/W2097904015","https://openalex.org/W2103169695","https://openalex.org/W2107434243","https://openalex.org/W2111065594","https://openalex.org/W2111681808","https://openalex.org/W2112893975","https://openalex.org/W2115929723","https://openalex.org/W2124928988","https://openalex.org/W2128022125","https://openalex.org/W2130734362","https://openalex.org/W2130753694","https://openalex.org/W2131138310","https://openalex.org/W2131616732","https://openalex.org/W2135749989","https://openalex.org/W2139491374","https://openalex.org/W2140857653","https://openalex.org/W2141352921","https://openalex.org/W2142283642","https://openalex.org/W2149307297","https://openalex.org/W2150916538","https://openalex.org/W2152746956","https://openalex.org/W2153889396","https://openalex.org/W2159597833","https://openalex.org/W2164273115","https://openalex.org/W2170016744","https://openalex.org/W2222772859","https://openalex.org/W2316918019","https://openalex.org/W2339901904","https://openalex.org/W2417021898","https://openalex.org/W2952025169","https://openalex.org/W3021870865","https://openalex.org/W3023204151","https://openalex.org/W3142499091"],"related_works":["https://openalex.org/W2181814166","https://openalex.org/W2018076136","https://openalex.org/W2013322023","https://openalex.org/W4302422818","https://openalex.org/W7027043307","https://openalex.org/W2561081388","https://openalex.org/W2756324351","https://openalex.org/W4396732710","https://openalex.org/W2159132498","https://openalex.org/W2131163406"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
