{"id":"https://openalex.org/W2069078564","doi":"https://doi.org/10.1016/s0960-9822(98)70468-3","title":"Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton","display_name":"Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2069078564","doi":"https://doi.org/10.1016/s0960-9822(98)70468-3","mag":"2069078564","pmid":"https://pubmed.ncbi.nlm.nih.gov/9778532"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-9822(98)70468-3","doi":"https://doi.org/10.1016/s0960-9822(98)70468-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(98)70468-3","pdf_url":"http://www.cell.com/article/S0960982298704683/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0960982298704683/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012164218","display_name":"Ami Aronheim","orcid":"https://orcid.org/0000-0002-8575-4092","observed_orcids":["https://orcid.org/0000-0002-8575-4092"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ami Aronheim","raw_affiliation_strings":["Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa, 31096, Israel. aronheim@tx.technion.ac.il","Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa, 31096, Israel. aronheim@tx.technion.ac.il","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]},{"raw_affiliation_string":"Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023635723","display_name":"Yehoshua C. Broder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yehoshua C. Broder","raw_affiliation_strings":["Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aviva Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviva Cohen","raw_affiliation_strings":["Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, The Rappaport Family Institute of Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114010195","display_name":"Alexandra Fritsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Fritsch","raw_affiliation_strings":["Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111566510","display_name":"Barbara Belisle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Belisle","raw_affiliation_strings":["Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109899780","display_name":"Arie Abo","orcid":"https://orcid.org/0009-0006-7198-028X","observed_orcids":["https://orcid.org/0009-0006-7198-028X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arie Abo","raw_affiliation_strings":["Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012164218","https://openalex.org/A5109899780"],"corresponding_institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":2.7892,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.91225047,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"20","first_page":"1125","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/combined-heat-and-power","display_name":"combined heat and power","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pak2","display_name":"PAK2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/jnk-activation","display_name":"JNK activation","score":0.625},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lamellipodia","display_name":"lamellipodia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.5329999923706055},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sh3-binding-domain","display_name":"SH3-binding domain","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7693196535110474},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7231369018554688},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.7157403230667114},{"id":"https://openalex.org/C24901178","wikidata":"https://www.wikidata.org/wiki/Q7118116","display_name":"PAK1","level":3,"score":0.6916795969009399},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.6485402584075928},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6219342947006226},{"id":"https://openalex.org/C90301020","wikidata":"https://www.wikidata.org/wiki/Q14859810","display_name":"Filopodia","level":3,"score":0.5863595604896545},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5752636790275574},{"id":"https://openalex.org/C109185818","wikidata":"https://www.wikidata.org/wiki/Q3092607","display_name":"Lamellipodium","level":4,"score":0.49896907806396484},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.49408891797065735},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4399195909500122},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.43232178688049316},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.42966562509536743},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.4102970361709595},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3138652741909027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1540442705154419},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11303672194480896}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019893","descriptor_name":"Ribosomal Protein S6 Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020764","descriptor_name":"cdc42 GTP-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-9822(98)70468-3","doi":"https://doi.org/10.1016/s0960-9822(98)70468-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(98)70468-3","pdf_url":"http://www.cell.com/article/S0960982298704683/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},{"id":"pmid:9778532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9778532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current biology : CB","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0960-9822(98)70468-3","doi":"https://doi.org/10.1016/s0960-9822(98)70468-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0960-9822(98)70468-3","pdf_url":"http://www.cell.com/article/S0960982298704683/pdf","source":{"id":"https://openalex.org/S128425624","display_name":"Current Biology","issn_l":"0960-9822","issn":["0960-9822","1879-0445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306489","display_name":"Charles H. Revson Foundation","ror":"https://ror.org/02c9tf451"},{"id":"https://openalex.org/F4320306791","display_name":"Pancreatic Cancer Action Network","ror":"https://ror.org/03t5n9b81"},{"id":"https://openalex.org/F4320322248","display_name":"Israel Academy of Sciences and Humanities","ror":"https://ror.org/03c6c9520"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069078564.pdf"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1518370492","https://openalex.org/W1555692789","https://openalex.org/W1568345151","https://openalex.org/W1884315263","https://openalex.org/W1976160919","https://openalex.org/W2027810531","https://openalex.org/W2030140160","https://openalex.org/W2042584344","https://openalex.org/W2055181868","https://openalex.org/W2077792958","https://openalex.org/W2096791952","https://openalex.org/W2121810961","https://openalex.org/W4243003607"],"related_works":["https://openalex.org/W2015418369","https://openalex.org/W1555692789","https://openalex.org/W2047330178","https://openalex.org/W1978110693","https://openalex.org/W1969463341","https://openalex.org/W2002410732","https://openalex.org/W2028702404","https://openalex.org/W2000426106","https://openalex.org/W1996063901","https://openalex.org/W1985462906"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
