{"id":"https://openalex.org/W2069076844","doi":"https://doi.org/10.1097/jcp.0b013e31819a4bae","title":"Clonidine Improves Hyperarousal in Borderline Personality Disorder With or Without Comorbid Posttraumatic Stress Disorder","display_name":"Clonidine Improves Hyperarousal in Borderline Personality Disorder With or Without Comorbid Posttraumatic Stress Disorder","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2069076844","doi":"https://doi.org/10.1097/jcp.0b013e31819a4bae","mag":"2069076844","pmid":"https://pubmed.ncbi.nlm.nih.gov/19512980"},"language":"en","primary_location":{"id":"doi:10.1097/jcp.0b013e31819a4bae","doi":"https://doi.org/10.1097/jcp.0b013e31819a4bae","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jcp.0b013e31819a4bae","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108827837","display_name":"Andreas A. Ziegenhorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas A. Ziegenhorn","raw_affiliation_strings":["Departments of Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. andreas.ziegenhorn@charite.de","Departments of Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. andreas.ziegenhorn@charite.de","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Departments of Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035288806","display_name":"Stefan Roepke","orcid":"https://orcid.org/0000-0003-3165-8684","observed_orcids":["https://orcid.org/0000-0003-3165-8684"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefan Roepke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111918111","display_name":"Nicole C. Schommer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicole C. Schommer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070806454","display_name":"Angela Merkl","orcid":"https://orcid.org/0000-0002-8781-6859","observed_orcids":["https://orcid.org/0000-0002-8781-6859"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Angela Merkl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073883544","display_name":"Heidi Danker\u2010Hopfe","orcid":"https://orcid.org/0000-0001-7001-1715","observed_orcids":["https://orcid.org/0000-0001-7001-1715"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heidi Danker-Hopfe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042964327","display_name":"Frank Holger Perschel","orcid":"https://orcid.org/0000-0001-5223-6099","observed_orcids":["https://orcid.org/0000-0001-5223-6099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank H. Perschel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043504486","display_name":"Isabella Heuser","orcid":"https://orcid.org/0000-0001-7075-1158","observed_orcids":["https://orcid.org/0000-0001-7075-1158"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Isabella Heuser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111814545","display_name":"Ion George Anghelescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ion G. Anghelescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110351069","display_name":"Claas\u2010Hinrich Lammers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claas H. Lammers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035288806","https://openalex.org/A5043504486","https://openalex.org/A5070806454","https://openalex.org/A5073883544","https://openalex.org/A5108827837","https://openalex.org/A5110351069","https://openalex.org/A5111814545","https://openalex.org/A5111918111"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":5.6957,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95419318,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"2","first_page":"170","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11093","display_name":"Personality Disorders and Psychopathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11093","display_name":"Personality Disorders and Psychopathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":1.0},{"id":"https://openalex.org/keywords/borderline-personality-disorder","display_name":"borderline personality disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.972000002861023},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hyperarousal","display_name":"hyperarousal","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.6000000238418579},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"sleep quality","score":0.652999997138977},{"id":"https://openalex.org/keywords/adjunct-pharmacotherapy","display_name":"adjunct pharmacotherapy","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.8078446388244629},{"id":"https://openalex.org/C2780600973","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Borderline personality disorder","level":2,"score":0.7428914308547974},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.6791418790817261},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.5397033095359802},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5264452695846558},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.515861451625824},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.49187397956848145},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.48671844601631165},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4160436689853668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3313838243484497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2561908960342407},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001883","descriptor_name":"Borderline Personality Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001883","descriptor_name":"Borderline Personality Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001883","descriptor_name":"Borderline Personality Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/jcp.0b013e31819a4bae","doi":"https://doi.org/10.1097/jcp.0b013e31819a4bae","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jcp.0b013e31819a4bae","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:19512980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19512980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1698847126","https://openalex.org/W1812637898","https://openalex.org/W1976941847","https://openalex.org/W1983935031","https://openalex.org/W1995696853","https://openalex.org/W2020578215","https://openalex.org/W2024071094","https://openalex.org/W2029410796","https://openalex.org/W2046398833","https://openalex.org/W2061987281","https://openalex.org/W2067495470","https://openalex.org/W2069823940","https://openalex.org/W2076507685","https://openalex.org/W2077137402","https://openalex.org/W2083120492","https://openalex.org/W2112562480","https://openalex.org/W2121333311","https://openalex.org/W2130135754","https://openalex.org/W2149695401","https://openalex.org/W2149983839","https://openalex.org/W2160844797","https://openalex.org/W2163627052","https://openalex.org/W2170933900","https://openalex.org/W2415833327","https://openalex.org/W2507685650","https://openalex.org/W2913376288","https://openalex.org/W3171418018","https://openalex.org/W7074234824"],"related_works":["https://openalex.org/W2335146646","https://openalex.org/W2091504732","https://openalex.org/W1995696853","https://openalex.org/W2313705225","https://openalex.org/W3138465508","https://openalex.org/W1983828933","https://openalex.org/W2077137402","https://openalex.org/W4400112786","https://openalex.org/W2016114923","https://openalex.org/W2076174526"],"abstract_inverted_index":{"The":[0],"Diagnostic":[1],"and":[2,36,62,66,82,112,130],"Statistical":[3],"Manual":[4],"of":[5,64,72,106,134,151],"Mental":[6],"Disorders,":[7],"Fourth":[8],"Edition":[9],"borderline":[10],"personality":[11],"disorder":[12,39],"(BPD)":[13],"seems":[14],"to":[15,50,157,166],"constitute":[16],"a":[17,42,70,84,163,188],"very":[18],"heterogeneous":[19],"category.":[20],"Therefore,":[21],"pharmacological":[22],"therapy":[23],"is":[24],"symptom-oriented":[25],"or":[26,78],"targets":[27],"comorbid":[28,80],"conditions.":[29],"A":[30],"high":[31],"comorbidity":[32],"exists":[33],"between":[34],"BPD":[35,171,185],"posttraumatic":[37],"stress":[38],"(PTSD).":[40],"In":[41],"double-blind,":[43],"randomized,":[44],"placebo-controlled":[45],"crossover":[46],"study,":[47,154],"we":[48],"sought":[49],"determine":[51],"whether":[52],"the":[53,92,119,123,131,135,142,147],"antinoradrenergic":[54],"agent":[55],"clonidine":[56,160],"was":[57],"effective":[58],"in":[59,69,110,118,141,168,180,182],"reducing":[60],"hyperarousal":[61,86,175],"measures":[63],"BPD-specific":[65],"general":[67,111],"psychopathology":[68,114],"sample":[71,149],"18":[73],"patients":[74,169,183],"with":[75,77,83,100,170,184],"BPD,":[76],"without":[79],"PTSD,":[81],"prominent":[85],"syndrome.":[87],"Hyperarousal":[88],"as":[89],"measured":[90],"by":[91],"Clinician":[93],"Administered":[94],"PTSD":[95,107,189],"scale":[96],"improved":[97,140],"significantly":[98],"compared":[99],"placebo":[101],"(P":[102,127,137],"=":[103,128,138],"0.003)":[104],"irrespective":[105],"comorbidity.":[108,190],"Improvements":[109],"BPD-typical":[113],"were":[115],"mainly":[116],"seen":[117],"PTSD-positive":[120],"subgroup,":[121],"whereas":[122],"subjective":[124],"sleep":[125,136,177],"latency":[126],"0.005)":[129],"restorative":[132],"qualities":[133],"0.014)":[139],"whole":[143],"sample.":[144],"Improvements,":[145],"despite":[146],"small":[148],"size":[150],"this":[152],"pilot":[153],"lead":[155],"us":[156],"conclude":[158],"that":[159],"might":[161],"be":[162],"useful":[164],"adjunct":[165],"pharmacotherapy":[167],"who":[172,186],"have":[173,187],"marked":[174],"and/or":[176],"problems":[178],"and,":[179],"particular,":[181]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
