{"id":"https://openalex.org/W2069048417","doi":"https://doi.org/10.1136/adc.56.10.765","title":"Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease.","display_name":"Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease.","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W2069048417","doi":"https://doi.org/10.1136/adc.56.10.765","mag":"2069048417","pmid":"https://pubmed.ncbi.nlm.nih.gov/7305414","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1627327"},"language":"en","primary_location":{"id":"doi:10.1136/adc.56.10.765","doi":"https://doi.org/10.1136/adc.56.10.765","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.56.10.765","pdf_url":"https://adc.bmj.com/content/archdischild/56/10/765.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://adc.bmj.com/content/archdischild/56/10/765.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057952092","display_name":"Janet M. Topley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"J M Topley","raw_affiliation_strings":["Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]},{"raw_affiliation_string":"Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","institution_ids":["https://openalex.org/I4210129319"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D W Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"D W Rogers","raw_affiliation_strings":["Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]},{"raw_affiliation_string":"Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","institution_ids":["https://openalex.org/I4210129319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034430743","display_name":"MC Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"M C Stevens","raw_affiliation_strings":["Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","institution_ids":["https://openalex.org/I4210129319"]},{"raw_affiliation_string":"Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060324072","display_name":"Graham Roger Serjeant","orcid":"https://orcid.org/0000-0003-4684-0286","observed_orcids":["https://orcid.org/0000-0003-4684-0286"]},"institutions":[{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]}],"countries":["JM"],"is_corresponding":false,"raw_author_name":"G R Serjeant","raw_affiliation_strings":["Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories (Jamaica), University of the West Indies, Mona, Kingston 7, Jamaica WI","institution_ids":["https://openalex.org/I4210129319"]},{"raw_affiliation_string":"Medical Research Council Laboratories, University ofthe West Indies, Kingston, Jamaica","institution_ids":["https://openalex.org/I4210129319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210129319"],"apc_list":null,"apc_paid":null,"fwci":1.6144,"has_fulltext":true,"cited_by_count":172,"citation_normalized_percentile":{"value":0.84772873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"10","first_page":"765","last_page":"769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-sickle-cell-disease","display_name":"homozygous sickle cell disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/acute-splenic-sequestration","display_name":"acute splenic sequestration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypersplenism","display_name":"hypersplenism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cord-blood-screening","display_name":"cord blood screening","score":0.6489999890327454},{"id":"https://openalex.org/keywords/childhood-morbidity-and-mortality","display_name":"child morbidity and mortality","score":0.671999990940094},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6150000095367432},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9551471471786499},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.617600679397583},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5552809834480286},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5394637584686279},{"id":"https://openalex.org/C2908638955","wikidata":"https://www.wikidata.org/wiki/Q5121708","display_name":"CIRCULATORY FAILURE","level":2,"score":0.4688369333744049},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4608672559261322},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3297058939933777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3015385866165161}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006971","descriptor_name":"Hypersplenism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006971","descriptor_name":"Hypersplenism","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013158","descriptor_name":"Splenic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013158","descriptor_name":"Splenic Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/adc.56.10.765","doi":"https://doi.org/10.1136/adc.56.10.765","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.56.10.765","pdf_url":"https://adc.bmj.com/content/archdischild/56/10/765.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1627327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1627327","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Dis Child","raw_type":"Text"},{"id":"pmid:7305414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7305414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of disease in childhood","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/77a44fbc-fdec-49c4-a0d5-099393b88b9f","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/77a44fbc-fdec-49c4-a0d5-099393b88b9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stevens, MCG, Rogers, DW, Sergeant, GR & Topley, JM 1981, 'Acute splenic sequestration and hypersplenism in the first five years in homozygous Sickly Cell Disease', Archives of Disease in Childhood, vol. 56, pp. 765 - 770.","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1136/adc.56.10.765","doi":"https://doi.org/10.1136/adc.56.10.765","is_oa":true,"landing_page_url":"https://doi.org/10.1136/adc.56.10.765","pdf_url":"https://adc.bmj.com/content/archdischild/56/10/765.full.pdf","source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069048417.pdf","grobid_xml":"https://content.openalex.org/works/W2069048417.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1507926575","https://openalex.org/W1591480519","https://openalex.org/W1977152561","https://openalex.org/W2009287040","https://openalex.org/W2061677902","https://openalex.org/W2067977670","https://openalex.org/W2143088623","https://openalex.org/W2163762611","https://openalex.org/W2286424042","https://openalex.org/W2398402055","https://openalex.org/W4250948795"],"related_works":["https://openalex.org/W2070567906","https://openalex.org/W3021249922","https://openalex.org/W2085535566","https://openalex.org/W2078098575","https://openalex.org/W1692992908","https://openalex.org/W4206481119","https://openalex.org/W2018585773","https://openalex.org/W4388215862","https://openalex.org/W1969748109","https://openalex.org/W2585038641"],"abstract_inverted_index":{"A":[0],"cord":[1],"blood":[2],"screening":[3],"programme":[4],"initiated":[5],"in":[6,34,54,96,116,163],"June":[7],"1973":[8],"had":[9],"screened":[10],"68":[11],"000":[12],"normal":[13],"deliveries":[14],"by":[15,67,160],"February":[16],"1979":[17],"with":[18,77,128],"the":[19,35,55,138],"detection":[20],"of":[21,24,31,50,59,73,104,123,140,158],"216":[22],"cases":[23],"homozygous":[25],"sickle":[26],"cell":[27],"disease.":[28],"Regular":[29],"review":[30],"these":[32,148],"children":[33,97,117],"Medical":[36],"Research":[37],"Council":[38],"paediatric":[39],"clinic":[40],"has":[41],"identified":[42],"acute":[43,105,124,141],"splenic":[44,106,125,142],"sequestration":[45,126,143],"as":[46],"a":[47,132],"major":[48,121],"cause":[49],"morbidity":[51],"and":[52,81,151],"mortality":[53],"first":[56],"5":[57],"years":[58],"life.":[60],"In":[61],"addition":[62],"to":[63,92,146,156],"classical":[64],"episodes":[65,72,90,103,122],"characterised":[66],"peripheral":[68],"circulatory":[69],"failure,":[70],"minor":[71,89,119,149],"increasing":[74],"anaemia":[75],"associated":[76],"an":[78,82],"enlarging":[79],"spleen":[80],"active":[83],"marrow":[84],"were":[85],"also":[86,112,166],"common.":[87],"These":[88],"appeared":[91],"have":[93],"predictive":[94],"value":[95],"who":[98,165],"later":[99],"developed":[100],"severe":[101],"life-threatening":[102],"sequestration.":[107],"Sequestration.":[108],"Sustained":[109],"hypersplenism":[110],"was":[111],"appreciably":[113],"more":[114],"common":[115],"developing":[118],"or":[120],"compared":[127],"those":[129],"without":[130],"such":[131],"history.":[133],"It":[134],"is":[135],"proposed":[136],"that":[137,152],"classification":[139],"be":[144,154],"expanded":[145],"include":[147],"episodes,":[150],"consideration":[153],"given":[155],"prevention":[157],"recurrences":[159],"splenectomy":[161],"particularly":[162],"patients":[164],"develop":[167],"sustained":[168],"hypersplenism.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}