{"id":"https://openalex.org/W2069014655","doi":"https://doi.org/10.1016/0005-2760(91)90052-j","title":"A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase","display_name":"A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2069014655","doi":"https://doi.org/10.1016/0005-2760(91)90052-j","mag":"2069014655","pmid":"https://pubmed.ncbi.nlm.nih.gov/1905157"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2760(91)90052-j","doi":"https://doi.org/10.1016/0005-2760(91)90052-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2760(91)90052-j","pdf_url":null,"source":{"id":"https://openalex.org/S4210194106","display_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","issn_l":"0005-2760","issn":["0005-2760","1879-145X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024900910","display_name":"Nobufusa Serizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nobufusa Serizawa","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4210104626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071465257","display_name":"Tatsuji Matsuoka","orcid":"https://orcid.org/0000-0001-5982-4248","observed_orcids":["https://orcid.org/0000-0001-5982-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuji Matsuoka","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd., Hiromachi-I-chome, Shinagawa-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd., Hiromachi-I-chome, Shinagawa-ku, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024900910"],"corresponding_institution_ids":["https://openalex.org/I4210104626"],"apc_list":null,"apc_paid":null,"fwci":1.0406,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.73741572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1084","issue":"1","first_page":"35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.24959999322891235,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1632000058889389,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mevastatin","display_name":"mevastatin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cytochrome-p450-monooxygenases","display_name":"cytochrome P450 monooxygenase","score":0.859000027179718},{"id":"https://openalex.org/keywords/flavoprotein","display_name":"flavoprotein","score":0.7049999833106995},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fad","display_name":"FAD","score":0.4830000102519989},{"id":"https://openalex.org/keywords/flavin-mononucleotide","display_name":"flavin mononucleotide","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.7785053253173828},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7234220504760742},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.7092126607894897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5759157538414001},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5625400543212891},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.43556293845176697},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.4309975504875183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4159727692604065},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33896124362945557},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27870267629623413},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.04195326566696167}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005420","descriptor_name":"Flavoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017035","descriptor_name":"Pravastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2760(91)90052-j","doi":"https://doi.org/10.1016/0005-2760(91)90052-j","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2760(91)90052-j","pdf_url":null,"source":{"id":"https://openalex.org/S4210194106","display_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","issn_l":"0005-2760","issn":["0005-2760","1879-145X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","raw_type":"journal-article"},{"id":"pmid:1905157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1905157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1497083865","https://openalex.org/W1534835840","https://openalex.org/W1603225698","https://openalex.org/W1951469402","https://openalex.org/W1963829759","https://openalex.org/W1987098866","https://openalex.org/W1991535242","https://openalex.org/W2031107830","https://openalex.org/W2048377706","https://openalex.org/W2055561625","https://openalex.org/W2100837269","https://openalex.org/W2121633785","https://openalex.org/W2124799320","https://openalex.org/W2142877486","https://openalex.org/W2145512527"],"related_works":["https://openalex.org/W2142877486","https://openalex.org/W2084324411","https://openalex.org/W2005238784","https://openalex.org/W2518204866","https://openalex.org/W2022956083","https://openalex.org/W1560469755","https://openalex.org/W2085863220","https://openalex.org/W2406272785","https://openalex.org/W2024718601","https://openalex.org/W1602114529"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}